{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:53:24Z","timestamp":1783032804062,"version":"3.54.6"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004590","name":"Central Norway Regional Health Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Intravenous amiodarone is an irritant of peripheral blood vessels with phlebitis as an adverse effect. The aims were to determine the incidence of intravenous amiodarone-induced phlebitis, to describe adherence to a clinical practice guideline, and to determine how characteristics were distributed between those with and without phlebitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A prospective observational study was conducted. Adult patients treated with amiodarone through a peripheral intravenous catheter (PIVC) or a central venous catheter were included. PIVC characteristics were measured using the PIVC mini questionnaire. Patients with \u2265two signs of phlebitis were categorized as having phlebitis. Adherence to the clinical practice guideline was registered on a standard abstract sheet. Data were collected from the amiodarone start-up to 2 days after the amiodarone was discontinued. In total, 124 patients with amiodarone infusions were observed, of which 69% were administered via a PIVC. The phlebitis rate was 44%. Fifty-three per cent developed amiodarone-induced phlebitis during the infusion phase, while 47% presented phlebitis during the post-infusion phase. The three most observed signs or symptoms of phlebitis were redness (87%), pain (81%), and swelling (71%). The most commonly used PIVC site was the elbow, and 35% of the PIVCs were large (18 gauge), which was the last preferred site and size according to the clinical practice guideline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A large proportion of the patients developed amiodarone-induced phlebitis. The adherence to the clinical practice guideline was not optimal according to the PIVC recommendations. Prevention of amiodarone-induced phlebitis should have high priority to reduce patient harm.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvad003","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T12:55:14Z","timestamp":1672750514000},"page":"824-831","source":"Crossref","is-referenced-by-count":10,"title":["Amiodarone-induced phlebitis: incidence and adherence to a clinical practice guideline"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-3944","authenticated-orcid":false,"given":"Gunhild","family":"Br\u00f8rs","sequence":"first","affiliation":[{"name":"Clinic of Cardiology, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-0000","authenticated-orcid":false,"given":"Kari Hanne","family":"Gjeilo","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"},{"name":"Department of Cardiothoracic Surgery, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"},{"name":"Department of Public Health and Nursing, Norwegian University of Science and Technology , P.O. Box 8900, Torgarden, 7491 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2195-6082","authenticated-orcid":false,"given":"Tonje","family":"Lund","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-9562","authenticated-orcid":false,"given":"Karin","family":"Skevik","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5895-3662","authenticated-orcid":false,"given":"Elizabeth","family":"Aa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-029X","authenticated-orcid":false,"given":"Lise Husby","family":"H\u00f8vik","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing, Norwegian University of Science and Technology , P.O. Box 8900, Torgarden, 7491 Trondheim , Norway"},{"name":"Department of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-6014","authenticated-orcid":false,"given":"Torhild","family":"Skarsvaag","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-4838","authenticated-orcid":false,"given":"Ole Christian","family":"Mj\u00f8lstad","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology, St. Olavs Hospital, Trondheim University Hospital , Prinsesse Kristinas gate 3, 7030 Trondheim , Norway"},{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology , P.O. 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