{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:26:11Z","timestamp":1781245571746,"version":"3.54.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In patients with peripheral arterial disease (PAD), exercise therapy is recommended to relieve leg symptoms, as noted in the 2016 AHA\/ACC and 2017 ESC\/ESVS guidelines. We assessed the trainability for cardiopulmonary fitness (CPF) and quality of life (QOL); three distinct patient types, namely, PAD, heart failure (HF), and stroke, were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This is a multicentre, retrospective analysis of prospectively collected data from three clinical studies. Data collected from 123 patients who completed 36 sessions of supervised aerobic training of moderate intensity were analysed, with 28 PAD, 55 HF, and 40 stroke patients totalling 123. Before and after training, cardiopulmonary exercise testing with non-invasive cardiac output monitoring and QOL evaluation using a 36-Item Short Form Survey (SF-36) were performed. Non-response was defined as a negative change in the post-training value compared with that in the pre-training value. The result showed an improvement in CPF in all three groups. However, cardiorespiratory fitness (CRF) increased by a lesser extent in the PAD group than in the HF and stroke groups; the physical and mental component scores (MCS) of SF-36 exhibited a similar pattern. Non-response rates of peak V\u02d9O2, oxygen uptake efficiency slope, and MCS were higher in the PAD group. In the PAD group, non-responders regarding peak V\u02d9O2 had a higher pulse wave velocity than responders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with PAD following exercise therapy, CRF and QOL improved to a lesser extent on average; their non-response rate was also higher compared with that of HF or stroke patients. Therefore, a higher dose of exercise might be needed to elicit adaptation in PAD patients, especially those with high pulse wave velocity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvad044","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T17:25:26Z","timestamp":1683912326000},"page":"127-136","source":"Crossref","is-referenced-by-count":8,"title":["Trainability for cardiopulmonary fitness is low in patients with peripheral artery disease"],"prefix":"10.1093","volume":"23","author":[{"given":"Shu-Chun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, New Taipei Municipal Tucheng Hospital, Chang Gung Memorial Hospital , New Taipei City 236 , Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital , Linkou 333 , Taiwan"},{"name":"College of Medicine, Chang Gung University , Kwei-Shan, Tao-Yuan County 333 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hsiao","family":"Yeh","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University , Kwei-Shan, Tao-Yuan County 333 , Taiwan"},{"name":"Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital , Taoyuan 333 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chin","family":"Hsu","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University , Kwei-Shan, Tao-Yuan County 333 , Taiwan"},{"name":"Community Medicine Research Center, Chang Gung Memorial Hospital , Keelung 204 , Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital , No. 222, Maijin Rd., Anle Dist., Keelung City 204 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Keelung, Institute for Radiological Research, Chang Gung University, College of Medicine , Taoyuan , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University , Kwei-Shan, Tao-Yuan County 333 , Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital , Linkou 333 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chung","family":"Hsiao","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University , Kwei-Shan, Tao-Yuan County 333 , Taiwan"},{"name":"Department of Nephrology, New Taipei Municipal TuCheng Hospital , New Taipei City 236 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hung","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Thoracic and 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