{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:15:48Z","timestamp":1793924148050,"version":"4.8.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["B202314057822"],"award-info":[{"award-number":["B202314057822"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation Committee of Hunan Province","award":["2023JJ40558"],"award-info":[{"award-number":["2023JJ40558"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Although anxiety and depression are frequently linked to coronary heart disease, a network analysis of comorbid anxiety and depression and their association with quality of life (QoL) in patients undergoing percutaneous coronary intervention (PCI) remains unclear from the perspective of symptom interactions. We aimed to investigate the network structure and symptom patterns of anxiety and depression, and their relationship with QoL in patients undergoing PCI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This study included 528 patients undergoing PCI. The seven-item Generalized Anxiety Disorder Scale, nine-item Patient Health Questionnaire, and World Health Organization Quality of Life Questionnaire-Brief Version were used as measurement tools. The R software was used to construct and interpret the network structure. The symptoms \u2018sleep disturbance,\u2019 \u2018irritability,\u2019 and \u2018uncontrollable worry\u2019 showed the highest expected influence centrality. Three bridge symptoms were identified: \u2018sleep disturbance,\u2019 \u2018excessive worry,\u2019 and \u2018trouble relaxing.\u2019 Among the three strongest edges, two were associated with anxiety and depressive symptoms. Ten symptoms were directly associated with QoL, with \u2018fatigue\u2019 showing the strongest relationship. In the network comparison test, significant differences in global strength were observed between the male and female groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>\u2018Sleep disturbance,\u2019 plays a critical role in the current network, while \u2018excessive worry,\u2019 \u2018trouble relaxing,\u2019 and \u2018fatigue\u2019 were identified as key priorities owing to their high correlation with \u2018sleep disturbance\u2019 and QoL. Focusing on these symptoms may help mitigate the risk of multiple-symptom interactions and provide tailored intervention measures for patients undergoing PCI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>Chinese Clinical Trial Registry: ChiCTR230007581<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvaf062","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:42:45Z","timestamp":1744270965000},"page":"925-933","source":"Crossref","is-referenced-by-count":2,"title":["Symptom network structure of anxiety, depression, and their impact on quality of life in patients undergoing percutaneous coronary intervention: a cross-sectional study"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7694-3817","authenticated-orcid":false,"given":"Zhiqing","family":"He","sequence":"first","affiliation":[{"name":"Department of Nursing, University of South China , 28 Changshengxi Road, Hengyang, Hunan 421001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9421-7259","authenticated-orcid":false,"given":"Shulin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nursing, University of South China , 28 Changshengxi Road, Hengyang, Hunan 421001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0547-4215","authenticated-orcid":false,"given":"Jiachun","family":"You","sequence":"additional","affiliation":[{"name":"Department of Nursing, University of South China , 28 Changshengxi Road, Hengyang, Hunan 421001 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