{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T07:02:22Z","timestamp":1794294142555,"version":"4.9.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Key Clinical Specialty","award":["Z155080000004"],"award-info":[{"award-number":["Z155080000004"]}]},{"name":"Shanghai \u2018Rising Star of Medical Talent\u2019 Youth Development Program","award":["YYXX202302"],"award-info":[{"award-number":["YYXX202302"]}]},{"name":"Clinical Research Project of Health Industry of Shanghai Municipal Health Commission","award":["20224Y0155"],"award-info":[{"award-number":["20224Y0155"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370851"],"award-info":[{"award-number":["82370851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400999"],"award-info":[{"award-number":["82400999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762052"],"award-info":[{"award-number":["2024M762052"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Although several body sizes have been used in the adjustment of skeletal muscle mass (SMM), their predictive ability for cardiovascular events remained unclear. We aimed to assess and compare the predictive performance of SMM indices for cardiovascular events in the middle-aged and older population and evaluate their association according to different body shape subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This study included 1374 individuals (43.5% men) aged 50\u201380 years from four communities. The follow-up was conducted in 2021\u201322 with a mean follow-up of 7.5 years. Cardiovascular events were recorded by phone calls and further validated using electronic medical records. Baseline SMM was estimated using a bioelectrical impedance analyzer and adjusted for weight (SMM\/Wt), body mass index (SMM\/BMI), and visceral fat area (SMM\/VFA), respectively. The visceral fat area was measured using magnetic resonance imaging. During a median follow-up of 7.5 years, adjusted hazard ratios for the lowest tertile of SMM\/Wt, SMM\/BMI, and SMM\/VFA were 1.80 (95% CI 1.17\u20132.77), 1.83 (95% CI 1.15\u20132.91), and 1.56 (95% CI 0.99\u20132.46) compared with the highest tertile, respectively. Regarding C-statistics, net reclassification improvement, and integrated discrimination improvement, the greatest improvement was observed when adding SMM\/BMI to the model compared with SMM\/Wt or SMM\/VFA. Moreover, the association between SMM\/BMI and cardiovascular events persisted regardless of age, sex, and different body shape subgroups (all P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SMM indices were significantly associated with the incidence of cardiovascular events in the middle-aged and older population. SMM\/BMI appeared to be a better muscle-relevant risk factor for cardiovascular events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvaf107","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:51:36Z","timestamp":1749628296000},"page":"1110-1118","source":"Crossref","is-referenced-by-count":2,"title":["Optimal skeletal muscle mass index and incident cardiovascular events: insights from a longitudinal analysis"],"prefix":"10.1093","volume":"24","author":[{"given":"Tingting","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus , 600 Yishan Road, Shanghai 200233 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