{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:16:00Z","timestamp":1777709760377,"version":"3.51.4"},"reference-count":122,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate European Society of Cardiology (ESC) guideline-defined \u2018typical\u2019 and \u2018less typical\u2019 heart failure (HF) symptoms, as well as non-ESC symptoms, and to explore how ESC-defined symptoms vary by care setting, age, and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Mixed-method systematic review and narrative synthesis through six electronic databases. Quality was assessed using Joanna Briggs Institute critical appraisal checklists. Symptoms were grouped into ESC (typical\/less typical) and non-ESC symptoms. Differences in ESC typical and less typical symptoms were investigated in hospital vs. community, &amp;lt;65 vs. \u226565 years old age, and men vs. women. Fifty-eight papers (43 quantitative, 11 qualitative, and 4 mixed-method) were included. Fifty-six out of fifty-eight studies observed at least one of the ESC typical and\/or less typical symptoms. Some of the \u2018less typical symptoms\u2019 were rarely reported (e.g. wheezing in three and bendopnea in one). Thirty-eight non-ESC symptoms were observed in 58 studies. Some non-ESC symptoms were commonly observed [e.g. chest pain\/discomfort (37\/58), difficulty sleeping (32\/58), and nausea\/vomiting\/indigestion (30\/58)]. Cough, palpitations, and dizziness were observed more in community than hospital whereas wheezing was observed more in hospital. Typical symptoms (orthopnoea\/paroxysmal nocturnal dyspnoea\/swelling) were more often observed in cohorts \u226565 (than &amp;lt;65) years of age. Due to the paucity of women in studies, there was little information available to compare symptoms of men and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a more diverse range of symptoms among HF population than has previously been described. There is need for comprehensive, person-centred symptom assessment protocol and more inclusive clinical guidelines, highlighting symptom variability in HF population across different demographic and clinical variations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>PROSPERO CRD42020185786<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvaf148","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:45:26Z","timestamp":1753443926000},"page":"239-255","source":"Crossref","is-referenced-by-count":2,"title":["Full spectrum of symptoms associated with heart failure: a mixed method systematic review and narrative synthesis"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-7372","authenticated-orcid":false,"given":"Muzeyyen","family":"Seckin","sequence":"first","affiliation":[{"name":"School of Medicine, Dentistry and Nursing, University of Glasgow , 57\u201361 Oakfield Avenue, Glasgow G12 8LL ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-9496","authenticated-orcid":false,"given":"Mark C","family":"Petrie","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow , 126 University Place, Glasgow, G12 8TA ,","place":["UK"]},{"name":"NHS Greater Glasgow and Clyde , 1055 Great Western Rd, Glasgow, G12 0XH ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-8998","authenticated-orcid":false,"given":"Simon","family":"Stewart","sequence":"additional","affiliation":[{"name":"School of Medicine, Dentistry and Nursing, University of Glasgow , 57\u201361 Oakfield Avenue, Glasgow G12 8LL ,","place":["UK"]},{"name":"Institute of Health Research, Notre Dame University of Australia , 32 Mouat St, Fremantle, WA 6160 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-3436","authenticated-orcid":false,"given":"Bridget","family":"Johnston","sequence":"additional","affiliation":[{"name":"School of Medicine, Dentistry and Nursing, University of Glasgow , 57\u201361 Oakfield Avenue, Glasgow G12 8LL ,","place":["UK"]},{"name":"NHS Greater Glasgow and Clyde , 1055 Great Western Rd, Glasgow, G12 0XH 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