{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T10:03:27Z","timestamp":1782036207826,"version":"3.54.5"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Montpellier University Hospital"},{"DOI":"10.13039\/501100003100","name":"French Federation of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The systemic right ventricle (SRV) represents one of the most complex congenital heart diseases (CHD), involving two main anatomical presentations: D-looped transposition of the great arteries and congenitally corrected transposition of the great arteries. Recent therapeutic advances have attempted to improve prognosis in adults with an SRV, but the impact on health-related quality of life (HRQoL) has not been clearly established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Adult patients aged &amp;gt;18 years with an SRV were prospectively enrolled in a multicentre cross-sectional study with recruitment across 13 CHD centres. Demographic, clinical, biological, and imaging data were analysed to assess HRQoL and its determinants. A total of 99 patients (mean age, 38.7 \u00b1 9.2 years; 52% male) were included. Most were symptomatic (NYHA II: 52.2%; NYHA III: 33.7%) with reduced exercise capacity (mean VO\u2082max = 20 \u00b1 6.1\u2005mL\/Kg\/min, i.e. 62.4\u00b116.8% of predicted values). HRQoL showed moderate impairment with a physical component score of 45.9 \u00b1 8.7 and a mental component score of 46.2 \u00b1 9.5. A lower physical component score was independently associated with a reduced VO\u2082max, a recent episode of decompensated heart failure, vitamin K antagonist medication, and being unemployed. The use of antiarrhythmic medications, the number of heart-failure related treatments, and being unemployed were independently associated to a lower mental component score, but having undergone interventional cardiac catheterization was associated with a better mental component score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HRQoL in adults with SRV shows moderate impairment compared to normative data. Cardiopulmonary fitness and clinical factors significantly influence physical and mental components of HRQoL, underscoring the importance of targeted interventions to optimize patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov ID: NCT03379831<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjcn\/zvaf156","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T11:42:32Z","timestamp":1754134952000},"page":"1260-1271","source":"Crossref","is-referenced-by-count":4,"title":["Health-related quality of life in patients with a systemic right ventricle: the QUALISYSTEMIC study"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-3103","authenticated-orcid":false,"given":"Paul","family":"Padovani","sequence":"first","affiliation":[{"name":"Paediatric and Congenital Cardiology Department, M3C National Reference Centre, Bordeaux University Hospital , Av. Magellan, 33600 Pessac ,","place":["France"]},{"name":"INSERM, CIC FEA 1413, Nantes University , 8 Quai Moncousu, 44007 Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Werner","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital , 191 Av. du Doyen Gaston Giraud, 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Huguet","sequence":"additional","affiliation":[{"name":"Epidemiology and Clinical Research Department, Clinical Investigation Centre, INSERM U1411, Montpellier University Hospital , 39 avenue Charles Flahault, 34295 Montpellier cedex 5 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2061-1437","authenticated-orcid":false,"given":"Guy","family":"Vaksmann","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Unit, Clinique la Louviere , 69 rue de la Louviere, 59800 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-7432","authenticated-orcid":false,"given":"Xavier","family":"Iriart","sequence":"additional","affiliation":[{"name":"Paediatric and Congenital Cardiology Department, M3C National Reference Centre, Bordeaux University Hospital , Av. Magellan, 33600 Pessac ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-965X","authenticated-orcid":false,"given":"Jean-Benoit","family":"Thambo","sequence":"additional","affiliation":[{"name":"Paediatric and Congenital Cardiology Department, M3C National Reference Centre, Bordeaux University Hospital , Av. Magellan, 33600 Pessac ,","place":["France"]},{"name":"Department of Congenital Cardiology, Clinique Pasteur , 45 Av. de Lombez, 31076, Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Pierard","sequence":"additional","affiliation":[{"name":"Department of Congenital Cardiology, Cliniques Universitaires Saint-Luc, UCL , Av. Hippocrate 10, 1200, Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-6604","authenticated-orcid":false,"given":"Agnes","family":"Pasquet","sequence":"additional","affiliation":[{"name":"Department of Congenital Cardiology, Cliniques Universitaires Saint-Luc, UCL , Av. Hippocrate 10, 1200, Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Domanski","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Lille University Hospital , 2 Av. Oscar Lambret, 59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Godart","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Lille University Hospital , 2 Av. Oscar Lambret, 59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Bredy","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital , 191 Av. du Doyen Gaston Giraud, 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-7544","authenticated-orcid":false,"given":"Bruno","family":"Lefort","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Tours University Hospital , 49 Bd B\u00e9ranger, 37044 Tours ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-9719","authenticated-orcid":false,"given":"Laurence","family":"Iserin","sequence":"additional","affiliation":[{"name":"Adult Congenital Cardiology Department, M3C National Reference Centre, Hopital Europeen Georges Pompidou, APHP , 20 Rue Leblanc, 75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3521","authenticated-orcid":false,"given":"Magalie","family":"Ladouceur","sequence":"additional","affiliation":[{"name":"Adult Congenital Cardiology Department, M3C National Reference Centre, Hopital Europeen Georges Pompidou, APHP , 20 Rue Leblanc, 75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Karsenty","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Toulouse University Hospital , 2 Rue Charles Viguerie, 31300 Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Maragnes","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Caen University Hospital , Av. de la C\u00f4te de Nacre CS 30001, 14000 Caen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Moceri","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Nice University Hospital , 4 All. de la Reine, 06000 Nice ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cohen","sequence":"additional","affiliation":[{"name":"Pediatric and Adult Congenital Cardiology Department, M3C National Reference Centre, Marie-Lannelongue Cardiothoracic Surgical Centre, Saint-Joseph Hospital , 133 Av. de la Resistance, 92350 Le Plessis-Robinson ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Hascoet","sequence":"additional","affiliation":[{"name":"Pediatric and Adult Congenital Cardiology Department, M3C National Reference Centre, Marie-Lannelongue Cardiothoracic Surgical Centre, Saint-Joseph Hospital , 133 Av. de la Resistance, 92350 Le Plessis-Robinson ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Cohen","sequence":"additional","affiliation":[{"name":"Foetal, Paediatric and Adult Congenital Cardiology Explorations Unit, ETCC , 8 Rue du Conseil de l'Europe, 91300 Massy ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Andrianoely","sequence":"additional","affiliation":[{"name":"Just Coaching , 66 Av. des Champs-Elysees, 75008 Paris ,","place":["France"]},{"name":"INSERM 1045, IHU Liryc, Cardio-Thoracic Research Center, Bordeaux University , Avenue de Magellan Pessac Cedex 33604 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-7791","authenticated-orcid":false,"given":"Nicolas","family":"Combes","sequence":"additional","affiliation":[{"name":"Department of Congenital Cardiology, Clinique Pasteur , 45 Av. de Lombez, 31076, Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamouda","family":"Abassi","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital , 191 Av. du Doyen Gaston Giraud, 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-7299","authenticated-orcid":false,"given":"Marie-Christine","family":"Picot","sequence":"additional","affiliation":[{"name":"Epidemiology and Clinical Research Department, Clinical Investigation Centre, INSERM U1411, Montpellier University Hospital , 39 avenue Charles Flahault, 34295 Montpellier cedex 5 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"Cornuault","sequence":"additional","affiliation":[{"name":"Paediatric and Congenital Cardiology Department, M3C National Reference Centre, Bordeaux University Hospital , Av. Magellan, 33600 Pessac ,","place":["France"]},{"name":"INSERM 1045, IHU Liryc, Cardio-Thoracic Research Center, Bordeaux University , Avenue de Magellan Pessac Cedex 33604 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3649-0294","authenticated-orcid":false,"given":"Pascal","family":"Amedro","sequence":"additional","affiliation":[{"name":"Paediatric and Congenital Cardiology Department, M3C National Reference Centre, Bordeaux University Hospital , Av. 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