{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:49:26Z","timestamp":1790804966748,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2009,3,29]],"date-time":"2009-03-29T00:00:00Z","timestamp":1238284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n Inflammation contributes to increased cardiovascular morbidity and mortality associated with activation of the renin\u2013angiotensin\u2013aldosterone system. The aim of this study was to investigate whether eplerenone, a selective aldosterone receptor antagonist, has anti-inflammatory effects on viral myocarditis.<\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n Four-week-old inbred male DBA\/2 mice were inoculated intraperitoneally with 10 plaque-forming units (pfu) of the encephalomyocarditis (EMC) virus. Mice were fed with standard chow (control) or with chow containing 2.5 mg\/kg of eplerenone, starting either on day 0 (inoculation) or day 7. Survival at 28 days was significantly higher in the mice which started eplerenone treatment on day 0 (35 vs. 15% in controls, each n = 40, P &lt; 0.05). The area of myocardial fibrosis on day 28 was significantly smaller in the eplerenone-treated mice than in controls (19.8 \u00b1 2.6%, n = 14, vs. 33.4 \u00b1 5.4%, n = 6, mean \u00b1 SEM, P &lt; 0.05). Gene expression of mouse mast cell proteases-4 and -5, matrix metalloproteinase-9, and type I procollagen on day 6 after EMC virus inoculation was significantly decreased in the hearts of eplerenone-treated mice.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These results suggest that eplerenone has anti-inflammatory effects, and exerts its beneficial effects on viral myocarditis by suppression of genes related to mast cells and cardiac remodelling in the hearts of mice.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfp023","type":"journal-article","created":{"date-parts":[[2009,2,12]],"date-time":"2009-02-12T20:34:47Z","timestamp":1234470887000},"page":"349-353","source":"Crossref","is-referenced-by-count":49,"title":["Anti-Inflammatory Effects of Eplerenone on Viral Myocarditis"],"prefix":"10.1093","volume":"11","author":[{"given":"Jie","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine , 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto, 606-8507 ,","place":["Japan"]},{"name":"Beijing Tongren Hospital, Capital Medical University , Beijing, 100730 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine , 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto, 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine , 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto, 606-8507 ,","place":["Japan"]},{"name":"Peking University People\u2019s Hospital \u00a0","place":["People\u2019s Republic of 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