{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:25:11Z","timestamp":1791563111190,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T00:00:00Z","timestamp":1245801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We sought to determine whether repeat administration of bone marrow mononuclear cells (BMC) can improve left ventricular function compared with a single infusion in patients with large acute myocardial infarction (AMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Thirty-nine patients with a ST-elevation AMI of the anterior wall and a significantly decreased left ventricular ejection fraction (LVEF 20\u201339%) were randomly assigned to three groups following primary percutaneous coronary intervention: Group A (n = 12) received a single intracoronary infusion of BMC (1.9 \u00b1 1.2 \u00d7 108) at 3\u20137 days after AMI; Group B (n = 15) received BMC administration both at 3\u20137 days (2.0 \u00b1 1.4 \u00d7 108) and at 3 months (2.1 \u00b1 1.7 \u00d7 108); and the control group (CON, n = 12) received one placebo injection at 3\u20137 days. We noted no severe complications associated with the BMC transfer. The increase in LVEF evaluated by magnetic resonance imaging (MRI) after 12 months in Group B (11.7 \u00b1 2.6%) was significantly greater than that in Group A (7.2 \u00b1 1.6%, P &amp;lt; 0.001) or in CON (2.9 \u00b1 2.0%, P &amp;lt; 0.001). Magnetic resonance imaging-derived myocardial infarct size decreased significantly in Group B compared with Group A (11.3 \u00b1 2.7% vs. 6.3 \u00b1 1.6%, P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Data from this preliminary study suggest that repeated BMC administration might be a safe and feasible therapeutic strategy for patients with large AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfp062","type":"journal-article","created":{"date-parts":[[2009,5,6]],"date-time":"2009-05-06T20:24:30Z","timestamp":1241641470000},"page":"691-698","source":"Crossref","is-referenced-by-count":64,"title":["Repeated Autologous Bone Marrow Mononuclear Cell Therapy in Patients with Large Myocardial Infarction"],"prefix":"10.1093","volume":"11","author":[{"given":"Kang","family":"Yao","sequence":"first","affiliation":[{"name":"Department of 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juying","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Feng Lin Road, Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Feng Lin Road, Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Feng Lin Road, Shanghai, 200032 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