{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:56:14Z","timestamp":1770058574796,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T00:00:00Z","timestamp":1250726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiomyocyte apoptosis is reported to be involved in the pathogenesis of human chronic Chagas cardiomyopathy (CCC). Members of the tumour necrosis factor (TNF) superfamily (TNF-\u03b1, FasLigand\/CD95L, and TNF-related apoptosis-inducing ligand) are known to activate the death receptor pathway. We therefore investigated whether levels of TNF-\u03b1, FasLigand\/CD95L, and TRAIL correlated with changes in heart function of patients with Chagas disease (n = 31).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Concentrations of TNF-\u03b1 and TRAIL were clearly augmented in individuals with severe form CCC (n = 16). Levels of FasLigand\/CD95L were greater in chagasic patients than in non-infected individuals (n = 15) but did not differentiate between clinical forms of Chagas disease. There was a good correlation between TNF-\u03b1 (r = 0.85 and r = 0.68, P &amp;lt; 0.0001) or TRAIL (r = 0.68 and r = 0.60, P &amp;lt; 0.001) and left ventricular ejection fraction (LVEF) and left ventricular diastolic diameter (LVDD), respectively. In addition, TNF-\u03b1 (r = 0.57, P = 0.0001), TRAIL (r = 0.56, P = 0.001), and FasLigand\/CD95L (r = 0.51, P = 0.001) showed a good correlation with brain natriuretic peptide, a well-known parameter of ventricular dysfunction in CCC. There was a weak correlation between levels of FasLigand\/CD95L (r = 0.50, P &amp;lt; 0.004) and both LVEF and LVDD. There was no correlation between levels of TNF superfamily ligands and chronotropic incompetence, maximal heart rate, or number of ventricular premature beats in 24 h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma levels of TNF superfamily ligands are elevated in patients with functional but not arrhythmogenic disturbances, and these death receptor ligands may be potential markers of ventricular dysfunction in CCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfp105","type":"journal-article","created":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T20:34:03Z","timestamp":1249418043000},"page":"825-831","source":"Crossref","is-referenced-by-count":33,"title":["Plasma Concentrations of Tumour Necrosis Factor-Alpha, Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand, and FasLigand\/CD95L in Patients with Chagas Cardiomyopathy Correlate with Left Ventricular Dysfunction"],"prefix":"10.1093","volume":"11","author":[{"given":"Jamille Fernandes","family":"Lula","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de doen\u00e7a de Chagas, Departamento de Ci\u00eancias Biol\u00f3gicas & N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Ouro Preto, Campus universit\u00e1rio, Morro do Cruzeiro , Ouro Preto, MG, 35400\u2013000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Otavio da Costa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo Horizonte, MG, 31130\u20131000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo","family":"Pereira Nunes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo Horizonte, MG, 31130\u20131000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Luiz Pinho","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo Horizonte, MG, 31130\u20131000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofarmacologia, Departamento de Bioqu\u00edmica e Imunologia, Instituto Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Belo Horizonte, MG, 31270\u2013901 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Terezinha","family":"Bahia","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de doen\u00e7a de Chagas, Departamento de Ci\u00eancias Biol\u00f3gicas & N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Ouro Preto, Campus universit\u00e1rio, Morro do Cruzeiro , Ouro Preto, MG, 35400\u2013000 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Talvani","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de doen\u00e7a de Chagas, Departamento de Ci\u00eancias Biol\u00f3gicas & N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Ouro Preto, Campus universit\u00e1rio, Morro do Cruzeiro , Ouro Preto, MG, 35400\u2013000 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