{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:01:15Z","timestamp":1770069675994,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:00:00Z","timestamp":1258588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009. The AAA study does not support the routine use of aspirin for the prevention of vascular events in patients with asymptomatic atherosclerosis. RELY suggests that dabigatran may be more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Rolofylline was not superior to placebo in improving outcomes in patients with acute heart failure enrolled in the PROTECT study, but dyspnoea was improved. Data from ACTIVE-I suggest that irbesartan does not provide additional therapeutic benefit in patients with atrial fibrillation who are well controlled on current therapy. The European cardiac resynchronization therapy (CRT) survey provides interesting epidemiological data on current CRT device usage. The German pre-SCD II registry identified a low prevalence of patients with a reduced ejection fraction following myocardial infarction. Implantation of CRT-D rather than an implantable cardioverter defibrillator in patients with mild heart failure and QRS \u2265130 ms reduced the risk of hospitalization for heart failure in MADIT-CRT; mortality was similarly low with each device.<\/jats:p>","DOI":"10.1093\/eurjhf\/hfp162","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T23:52:52Z","timestamp":1258674772000},"page":"1214-1219","source":"Crossref","is-referenced-by-count":37,"title":["Clinical Trials Update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRT"],"prefix":"10.1093","volume":"11","author":[{"given":"John G.F.","family":"Cleland","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison P.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Buga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Torabi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital , Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,11,19]]},"reference":[{"key":"2026020203370274500_ejhfhfp162-bib-0001","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(09)60503-1","article-title":"Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials","volume":"373","author":"Antithrombotic Trialists (ATT) Collaboration","year":"2009","journal-title":"Lancet"},{"key":"2026020203370274500_ejhfhfp162-bib-0002","doi-asserted-by":"crossref","first-page":"810.e1","DOI":"10.1016\/j.ahj.2009.02.005","article-title":"Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin compared with dabigatran","volume":"157","author":"Ezekowitz","year":"2009","journal-title":"Am Heart J"},{"key":"2026020203370274500_ejhfhfp162-bib-0003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"N Engl J Med"},{"key":"2026020203370274500_ejhfhfp162-bib-0004","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejheart.2008.01.010","article-title":"Adenosine and kidney function: potential implications in patients with heart failure","volume":"10","author":"Vallon","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0005","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ejheart.2006.07.003","article-title":"Clinical trials update from the European Society of Cardiology heart failure meeting: TNT subgroup analysis, darbepoetin alfa, FERRIC-HF and KW-3902","volume":"8","author":"Coletta","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0006","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ejheart.2008.05.003","article-title":"Clinical trials update from the American College of Cardiology 2008: CARISMA, TRENDS, meta-analysis of cyclo-oxygenase-2 data, HAT, studies related to hypertension, MOMENTUM, PROTECT, HORIZON-HF and REVERSE","volume":"10","author":"Cleland","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0007","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cardfail.2008.08.010","article-title":"The PROTECT pilot study: a randomized placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment","volume":"14","author":"Cotter","journal-title":"J Card Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0008","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.ahj.2005.06.026","article-title":"Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events","volume":"151","author":"Connolly","year":"2006","journal-title":"Am Heart J"},{"key":"2026020203370274500_ejhfhfp162-bib-0009","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(06)68845-4","article-title":"Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial","volume":"367","author":"Connolly","year":"2006","journal-title":"Lancet"},{"key":"2026020203370274500_ejhfhfp162-bib-0010","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMoa0901301","article-title":"Effect of clopidogrel added to aspirin in patients with atrial fibrillation","volume":"360","author":"The ACTIVE Investigators","year":"2009","journal-title":"N Engl J Med"},{"key":"2026020203370274500_ejhfhfp162-bib-0011","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/eurjhf\/hfp030","article-title":"European cardiac resynchronisation therapy survey: rational and design","volume":"11","author":"The CRT survey scientific committee","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0012","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1093\/eurheartj\/ehp359","article-title":"The European cardiac resynchronisation therapy survey","volume":"30","author":"Dickstein","year":"2009","journal-title":"Eur Heart J"},{"key":"2026020203370274500_ejhfhfp162-bib-0013","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2005.12.048","article-title":"Time dependence of defibrillator benefit after coronary revascularization in the multicentre automatic defibrillator implantation trial","volume":"47","author":"Goldenberg","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2026020203370274500_ejhfhfp162-bib-0014","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1056\/NEJMoa041489","article-title":"Prophylactic use of an implantable cardioverter defibrillator after acute myocardial infarction","volume":"351","author":"Hohnloser","year":"2004","journal-title":"N Engl J Med"},{"key":"2026020203370274500_ejhfhfp162-bib-0015","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ejheart.2008.08.005","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008 The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)","volume":"10","author":"Dickstein","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0016","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/eurheartj\/ehn096","article-title":"The timing of development and subsequent clinical course of heart failure after a myocardial infarction","volume":"29","author":"Torabi","year":"2008","journal-title":"Eur Heart J"},{"key":"2026020203370274500_ejhfhfp162-bib-0017","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S0002-9149(98)00158-1","article-title":"Changes in absolute and relative importance in the prognostic value of left ventricular systolic function and congestive heart failure after acute myocardial infarction. TRACE Study Group. Trandolapril Cardiac Evaluation","volume":"81","author":"Kober","year":"1988","journal-title":"Am J Cardiol"},{"key":"2026020203370274500_ejhfhfp162-bib-0018","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.ehj.2004.08.006","article-title":"An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry","volume":"25","author":"Velazquez","year":"2004","journal-title":"Eur Heart J"},{"key":"2026020203370274500_ejhfhfp162-bib-0019","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S1388-9842(03)00159-4","article-title":"Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications","volume":"5","author":"Moller","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0020","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","article-title":"Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms","volume":"52","author":"Linde","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026020203370274500_ejhfhfp162-bib-0021","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/eurjhf\/hfp071","article-title":"Clinical trials update from the American College of Cardiology 2009: ADMIRE-HF, PRIMA, STICH, REVERSE, IRIS, partial ventricular support, FIX-HF-5, vagal stimulation, REVIVAL-3, pre-RELAX-AHF, ACTIVE-A, HF-ACTION, JUPITER, AURORA, and OMEGA","volume":"11","author":"Cleland","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026020203370274500_ejhfhfp162-bib-0022","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/hrt.2007.128991","article-title":"Long term effect of cardiac resynchronisation in patients reporting mild symptoms of heart failure: a report from the CARE-HF study","volume":"94","author":"Cleland","year":"2008","journal-title":"Heart"},{"key":"2026020203370274500_ejhfhfp162-bib-0023","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1542-474X.2005.00073.x","article-title":"Multicentre automatic defibrillator implantation trial\u2014cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol","volume":"10","author":"Moss","year":"2005","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2026020203370274500_ejhfhfp162-bib-0024","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac resynchronisation therapy for the prevention of heart failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfp162","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfp162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1093\/eurjhf\/hfp162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1093\/eurjhf\/hfp162","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/11\/12\/1214\/66546217\/eurjhf_11_12_1214.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/11\/12\/1214\/66546217\/eurjhf_11_12_1214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:37:10Z","timestamp":1770021430000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/11\/12\/1214\/8438892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,19]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,11,19]]},"published-print":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfp162","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,12]]},"published":{"date-parts":[[2009,11,19]]}}}