{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:39:46Z","timestamp":1770057586624,"version":"3.49.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T00:00:00Z","timestamp":1261094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It remains unclear whether the combination of dual-chamber (DDD) pacing and disopyramide can achieve prolonged left ventricular outflow tract (LVOT) gradient reduction and symptom relief in patients with obstructive hypertrophic cardiomyopathy (HCM). In an HCM patient with a severe LVOT gradient, the combination of DDD pacing and disopyramide achieved marked improvement of gradient in the catheter laboratory and also after medium-term follow-up. The patient's severe dyspnoea was alleviated during the follow-up period. This combination might enable physicians to treat and manage elderly symptomatic obstructive HCM patients with a severe LVOT gradient more effectively and less invasively.<\/jats:p>","DOI":"10.1093\/eurjhf\/hfp166","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T18:33:20Z","timestamp":1259346800000},"page":"94-97","source":"Crossref","is-referenced-by-count":5,"title":["Possible Acute and Chronic Synergistic Effect of Dual Chamber Pacing and Disopyramide in Obstructive Hypertrophic Cardiomyopathy: A Case Report"],"prefix":"10.1093","volume":"12","author":[{"given":"Shintaro","family":"Haruki","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Kajimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bun","family":"Yashiro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kawana","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women's Medical University , 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,18]]},"reference":[{"key":"2026020203320812700_ejhfhfp166-bib-0001","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1056\/NEJMoa021332","article-title":"Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy","volume":"348","author":"Maron","year":"2003","journal-title":"N Engl J Med"},{"key":"2026020203320812700_ejhfhfp166-bib-0002","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.CIR.29.1.84","article-title":"Effects of beta adrenergic blockade on the circulation with particular reference to observations in patients with hypertrophic subaortic stenosis","volume":"29","author":"Harrison","year":"1964","journal-title":"Circulation"},{"key":"2026020203320812700_ejhfhfp166-bib-0003","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0002-9149(81)90086-2","article-title":"Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy: III. 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