{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:11:49Z","timestamp":1771906309412,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T00:00:00Z","timestamp":1263772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In patients with chronic heart failure (CHF), left bundle branch block (LBBB) is associated with an increased risk of cardiovascular mortality. We aimed to investigate the association of LBBB with short- and long-term outcome in patients discharged after a de novo episode of acute heart failure (AHF) or AHF complicating a mild CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with no history of New York Heart Association class III and IV CHF, who were admitted for a severe AHF episode and enrolled in the prospective observational EFICA study (n = 403), were included. Left bundle branch block prevalence was 16%. Patients with LBBB had a higher prevalence of dilated cardiomyopathy (23 vs. 10%, P &amp;lt; 0.005), a higher percentage of AHF episodes without identified precipitating factor (15 vs. 2%, P &amp;lt; 0.001), and were less likely to present increased markers of cardiac injury (41 vs. 56%, P = 0.04). The 4-week mortality was 24.8% with no difference between LBBB and no LBBB patients. Left bundle branch block was however an independent predictor of 1-year mortality in the 4-week survivors [hazards ratio (95% confidence interval) = 2.01 (1.12\u20133.64), P = 0.02].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term outcome of patients surviving a severe episode of de novo AHF or AHF complicating a mild CHF is worsened by LBBB. These patients may constitute a subgroup at high risk in whom specific therapeutic solutions should be investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfp180","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T20:19:33Z","timestamp":1261513173000},"page":"156-163","source":"Crossref","is-referenced-by-count":29,"title":["Left Bundle Branch Block and Mortality in Patients with Acute Heart Failure Syndrome: A Substudy of the EFICA Cohort"],"prefix":"10.1093","volume":"12","author":[{"given":"Etienne","family":"Huvelle","sequence":"first","affiliation":[{"name":"CIC-INSEM-CHU, Nancy, H\u00f4pital Jeanne d'Arc, BP 90303 , 54201, Toul Cedex ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Fay","sequence":"additional","affiliation":[{"name":"CIC-INSEM-CHU, Nancy, H\u00f4pital Jeanne d'Arc, BP 90303 , 54201, Toul Cedex ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Alla","sequence":"additional","affiliation":[{"name":"CEC-INSEM-CHU , Nancy ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Cohen Solal","sequence":"additional","affiliation":[{"name":"APHP, Department of Cardiology, Lariboisi\u00e8re Hospital, U942 Inserm, Universit\u00e9 Paris Diderot , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"APHP, Department of Anesthesiology and Critical Care Medicine, Lariboisi\u00e8re Hospital, U942 Inserm, Universit\u00e9 Paris Diderot , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"CIC-INSEM-CHU, Nancy, H\u00f4pital Jeanne d'Arc, BP 90303 , 54201, Toul Cedex ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,1,18]]},"reference":[{"key":"2026020203362680300_ejhfhfp180-bib-0001","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.CIR.51.3.477","article-title":"A clinical and follow-up study of right and left bundle branch block","volume":"51","author":"Rotman","year":"1975","journal-title":"Circulation"},{"key":"2026020203362680300_ejhfhfp180-bib-0002","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0002-8703(70)90135-3","article-title":"Acquired bundle branch block in a healthy population","volume":"80","author":"Smith","year":"1970","journal-title":"Am Heart J"},{"key":"2026020203362680300_ejhfhfp180-bib-0003","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0002-9149(96)00160-9","article-title":"Natural history of isolated bundle branch block","volume":"77","author":"Fahy","year":"1996","journal-title":"Am J Cardiol"},{"key":"2026020203362680300_ejhfhfp180-bib-0004","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.98.22.2494","article-title":"Bundle-branch block in a general male population: the study of men born 1913","volume":"98","author":"Eriksson","year":"1998","journal-title":"Circulation"},{"key":"2026020203362680300_ejhfhfp180-bib-0005","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0002-9149(81)90196-X","article-title":"Comparative features of newly acquired left and right bundle branch block in the general population: the Framingham study","volume":"47","author":"Schneider","year":"1981","journal-title":"Am J Cardiol"},{"key":"2026020203362680300_ejhfhfp180-bib-0006","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1093\/eurheartj\/ehi580","article-title":"Bundle-branch block in middle-aged men: risk of complications and death over 28 years. 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