{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T07:25:57Z","timestamp":1770103557274,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T00:00:00Z","timestamp":1263772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acute heart failure syndromes, commonly recognized as de novo heart failure or acute decompensated chronic heart failure (ADHF), are characterized by a rapid onset or change in signs and symptoms of heart failure requiring urgent treatment. Coexisting renal dysfunction is associated with poor prognosis in these patients. We sought to determine whether renal impairment in particular and other admission factors in general predict long-term mortality after hospitalization for ADHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We studied 128 patients (age 63 \u00b1 12 years, 76% male) in NYHA class 2.6 \u00b1 0.7 with a left ventricular ejection fraction (LVEF) \u226439%, hospitalized due to ADHF. Mortality rates (per 100 person-years) were 21.9 at 12 months and 12.0 at 60 months. We found that admission serum creatinine level was the best predictor of mortality after 1 (P &amp;lt; 0.001, log-transformed due to skewed distribution) and 5 years (P = 0.001), followed by creatinine clearance, the use of loop diuretics, and digoxin. Moreover, higher NYHA class, decreased body mass index (BMI) and increased levels of urea predicted 1 and 5 years mortality on univariate analysis. In the multivariate analysis, creatinine, NYHA class, and LVEF emerged as independent predictors of mortality after 1 year, whereas BMI and the use of diuretics did not reach significance (joint \u03c72 = 29.40, P &amp;lt; 0.001). After 5 years, creatinine and NYHA class independently predicted all-cause mortality (joint \u03c72 = 22.71, P &amp;lt; 0.001), but BMI and age did not remain significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Admission creatinine level strongly predicts medium- and long-term mortality after hospitalization in patients with ADHF, and serves as a cheap and fast clinical marker to identify patients at risk of death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfp184","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T13:49:18Z","timestamp":1263822558000},"page":"122-128","source":"Crossref","is-referenced-by-count":25,"title":["The Impact of Impaired Renal Function on Mortality in Patients with Acutely Decompensated Chronic Heart Failure"],"prefix":"10.1093","volume":"12","author":[{"given":"Amalia","family":"Vaz P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Cardiology, Campus Virchow-Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Otawa","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg , Halle ,","place":["Germany"]},{"name":"Department of Cardiology, Diabetology and Endocrinology, Klinikum Magdeburg GmbH , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arabel V.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Virchow-Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stockburger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Virchow-Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"M\u00fcller-Werdan","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg , Halle ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Werdan","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg , Halle ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik B.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg , Halle ,","place":["Germany"]},{"name":"Department of Cardiology, Diabetology and Endocrinology, Klinikum Magdeburg GmbH , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rostock , Ernst-Heydemann Street 6, Rostock, 18057 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Rauchhaus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Virchow-Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, University Hospital Rostock , Ernst-Heydemann Street 6, Rostock, 18057 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