{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:04:22Z","timestamp":1791295462502,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Though various neurohormonal systems are concurrently activated during heart failure (HF), their biological effectors are not always easy to measure due to their short life in vivo, instability in biological samples, or very low concentrations. We measured the plasma concentrations of four stable precursor fragments of neurohormonal systems in patients with chronic HF and evaluated their relationship with outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This study was performed in 1237 patients with chronic and stable HF enrolled in the GISSI-heart failure trial (GISSI-HF). The following four precursor fragments, mid-regional pro-atrial natriuretic peptide (MR-proANP), mid-regional pro-adrenomedullin (MR-proADM), C-terminal pro-endothelin-1 (CT-proET-1) and C-terminal pro-vasopressin (CT-proAVP or copeptin), were measured at randomization and after 3 months. Baseline concentrations were independent predictors of clinical outcome (median follow-up 3.9 years). The addition of MR-proANP improved net reclassification for mortality when added to multivariable models based on clinical risk factors alone [net reclassification improvement (NRI) = 0.12, P = 0.0007] or together with NT-proBNP (NRI = 0.06, P = 0.01). Changes in MR-proANP concentrations were related to mortality [HR (95% CI) 1.38 (0.99\u20131.93), P = 0.0614 and 1.58 (1.13\u20132.21), P = 0.0078 in the middle and highest vs. lowest tertiles], while changes in the other markers were not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with chronic and stable HF enrolled in a multicentre, randomized, clinical trial, measurement of stable precursor fragments of vasoactive peptides provided prognostic information independent of natriuretic peptides which are currently the best biomarkers for risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfp206","type":"journal-article","created":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T20:32:08Z","timestamp":1264192328000},"page":"338-347","source":"Crossref","is-referenced-by-count":136,"title":["The Predictive Value of Stable Precursor Fragments of Vasoactive Peptides in Patients with Chronic Heart Failure: Data from the GISSI-Heart Failure (GISSI-HF) Trial"],"prefix":"10.1093","volume":"12","author":[{"given":"Serge","family":"Masson","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 , via La Masa 19, 20156, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Latini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 , via La Masa 19, 20156, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Carbonieri","sequence":"additional","affiliation":[{"name":"Ospedale Fracastoro , San Bonifacio ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Moretti","sequence":"additional","affiliation":[{"name":"Ospedale Generale CG Mazzoni , Ascoli Piceno ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Rossi","sequence":"additional","affiliation":[{"name":"CardioCentro Ticino , Lugano ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo","family":"Ciricugno","sequence":"additional","affiliation":[{"name":"Presidio Ospedaliero F. Ferrari , Casarano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche \u2018Mario Negri\u2019 , via La Masa 19, 20156, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Marchioli","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud , Santa Maria Imbaro ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Struck","sequence":"additional","affiliation":[{"name":"Research Department, B.R.A.H.M.S. Aktiengesellschaft , Hennigsdorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Research Department, B.R.A.H.M.S. Aktiengesellschaft , Hennigsdorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo P.","family":"Maggioni","sequence":"additional","affiliation":[{"name":"ANMCO Research Center , Florence ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Tognoni","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud , Santa Maria Imbaro ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"GVM Hospitals of Care and Research , Cotignola ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,3,24]]},"reference":[{"key":"2026020203355523000_ejhfhfp206-bib-0001","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/CIRCULATIONAHA.105.584102","article-title":"The Seattle Heart Failure Model: prediction of survival in heart failure","volume":"113","author":"Levy","year":"2006","journal-title":"Circulation"},{"key":"2026020203355523000_ejhfhfp206-bib-0002","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1056\/NEJMra0800239","article-title":"Biomarkers in heart failure","volume":"358","author":"Braunwald","year":"2008","journal-title":"N Engl J Med"},{"key":"2026020203355523000_ejhfhfp206-bib-0003","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0735-1097(92)90167-L","article-title":"The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure","volume":"20","author":"Packer","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0004","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.jacc.2007.09.021","article-title":"Natriuretic peptides","volume":"50","author":"Daniels","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0005","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1373\/clinchem.2003.021204","article-title":"Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma","volume":"50","author":"Morgenthaler","year":"2004","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0006","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1373\/clinchem.2005.051110","article-title":"Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay","volume":"51","author":"Morgenthaler","year":"2005","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0007","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1373\/clinchem.2005.065581","article-title":"Immunoluminometric assay for measurement of the C-terminal endothelin-1 precursor fragment in human plasma","volume":"52","author":"Papassotiriou","year":"2006","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0008","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","article-title":"Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin","volume":"52","author":"Morgenthaler","year":"2006","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0009","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ejheart.2004.03.001","article-title":"Rationale and design of the GISSI heart failure trial: a large trial to assess the effects of n-3 polyunsaturated fatty acids and rosuvastatin in symptomatic congestive heart failure","volume":"6","author":"Tavazzi","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"2026020203355523000_ejhfhfp206-bib-0010","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(08)61239-8","article-title":"Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial","volume":"372","author":"Tavazzi","year":"2008","journal-title":"Lancet"},{"key":"2026020203355523000_ejhfhfp206-bib-0011","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(08)61240-4","article-title":"Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial","volume":"372","author":"Tavazzi","year":"2008","journal-title":"Lancet"},{"key":"2026020203355523000_ejhfhfp206-bib-0012","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1373\/clinchem.2006.069575","article-title":"Direct comparison of B-type natriuretic peptide (BNP) and amino-terminal proBNP in a large population of patients with chronic and symptomatic heart failure: the Valsartan Heart Failure (Val-HeFT) data","volume":"52","author":"Masson","year":"2006","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0013","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","article-title":"A method of comparing the areas under receiver operating characteristic curves derived from the same cases","volume":"148","author":"Hanley","year":"1983","journal-title":"Radiology"},{"key":"2026020203355523000_ejhfhfp206-bib-0014","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"key":"2026020203355523000_ejhfhfp206-bib-0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0140-6736(85)90193-X","article-title":"Atrial natriuretic peptide concentrations in blood from right atrium in patient with severe right heart failure","volume":"2","author":"Hartter","year":"1985","journal-title":"Lancet"},{"key":"2026020203355523000_ejhfhfp206-bib-0016","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/01.CIR.92.3.286","article-title":"Elevation of circulating and ventricular adrenomedullin in human congestive heart failure","volume":"92","author":"Jougasaki","year":"1995","journal-title":"Circulation"},{"key":"2026020203355523000_ejhfhfp206-bib-0017","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0735-1097(83)80040-0","article-title":"Increased plasma arginine vasopressin levels in patients with congestive heart failure","volume":"1","author":"Goldsmith","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0018","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/01.CIR.85.2.510","article-title":"Elevated endothelin-1 in heart failure and loss of normal response to postural changes","volume":"85","author":"Stewart","year":"1992","journal-title":"Circulation"},{"key":"2026020203355523000_ejhfhfp206-bib-0019","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/01.CIR.85.4.1374","article-title":"Plasma endothelin in chronic heart failure","volume":"85","author":"McMurray","year":"1992","journal-title":"Circulation"},{"key":"2026020203355523000_ejhfhfp206-bib-0020","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1172\/JCI107423","article-title":"Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma","volume":"52","author":"Robertson","year":"1973","journal-title":"J Clin Invest"},{"key":"2026020203355523000_ejhfhfp206-bib-0021","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/clinchem\/44.3.571","article-title":"Adrenomedullin (1\u201352) measured in human plasma by radioimmunoassay: plasma concentration, adsorption, and storage","volume":"44","author":"Lewis","year":"1998","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0022","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1258\/0004563001899906","article-title":"Measurement of endothelin: clinical and research use","volume":"37","author":"Rossi","year":"2000","journal-title":"Ann Clin Biochem"},{"key":"2026020203355523000_ejhfhfp206-bib-0023","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2362.2006.01724.x","article-title":"Copeptin, a fragment of the vasopressin precursor, as a novel predictor of outcome in heart failure","volume":"36","author":"Stoiser","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"2026020203355523000_ejhfhfp206-bib-0024","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.jacc.2007.08.012","article-title":"Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure","volume":"50","author":"von Haehling","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0025","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jacc.2008.03.050","article-title":"Comparison of copeptin, B-type natriuretic peptide, and amino-terminal pro-B-type natriuretic peptide in patients with chronic heart failure: prediction of death at different stages of the disease","volume":"52","author":"Neuhold","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0026","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cardfail.2006.09.004","article-title":"Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and copeptin to predict 1-year mortality in patients with acute destabilized heart failure","volume":"13","author":"Gegenhuber","year":"2007","journal-title":"J Card Fail"},{"key":"2026020203355523000_ejhfhfp206-bib-0027","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cca.2008.10.012","article-title":"Chromogranin A and C-terminal endothelin-1 precursor fragment add independent prognostic information to amino-terminal proBNP in patients with acute destabilized heart failure","volume":"400","author":"Dieplinger","year":"2009","journal-title":"Clin Chim Acta"},{"key":"2026020203355523000_ejhfhfp206-bib-0028","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ahj.2007.06.016","article-title":"C-terminal pro-endothelin-1 offers additional prognostic information in patients after acute myocardial infarction: Leicester acute myocardial infarction peptide (LAMP) study","volume":"154","author":"Khan","year":"2007","journal-title":"Am Heart J"},{"key":"2026020203355523000_ejhfhfp206-bib-0029","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.106.685503","article-title":"C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester acute myocardial infarction peptide (LAMP) study","volume":"115","author":"Khan","year":"2007","journal-title":"Circulation"},{"key":"2026020203355523000_ejhfhfp206-bib-0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1373\/clinchem.2007.096529","article-title":"Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve","volume":"54","author":"Cook","year":"2008","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0031","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ejheart.2008.07.014","article-title":"State of the art: using natriuretic peptide levels in clinical practice","volume":"10","author":"Maisel","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026020203355523000_ejhfhfp206-bib-0032","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.amjcard.2007.11.024","article-title":"Amino-terminal pro-B-type natriuretic peptides and prognosis in chronic heart failure","volume":"101","author":"Masson","year":"2008","journal-title":"Am J Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0033","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/CIRCULATIONAHA.107.694562","article-title":"Serial biomarker measurements in ambulatory patients with chronic heart failure: the importance of change over time","volume":"116","author":"Miller","year":"2007","journal-title":"Circulation"},{"key":"2026020203355523000_ejhfhfp206-bib-0034","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.jacc.2006.10.081","article-title":"Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure: the STARS-BNP multicenter study","volume":"49","author":"Jourdain","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0035","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.amjcard.2007.11.027","article-title":"Outpatient monitoring and treatment of chronic heart failure guided by amino-terminal pro-B-type natriuretic peptide measurement","volume":"101","author":"Troughton","year":"2008","journal-title":"Am J Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0036","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1161\/01.CIR.0000054164.99881.00","article-title":"Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan heart failure trial (Val-HeFT)","volume":"107","author":"Anand","year":"2003","journal-title":"Circulation"},{"key":"2026020203355523000_ejhfhfp206-bib-0037","doi-asserted-by":"crossref","first-page":"70.e23","DOI":"10.1016\/j.amjmed.2005.08.041","article-title":"Incremental prognostic value of changes in B-type natriuretic peptide in heart failure","volume":"119","author":"Latini","year":"2006","journal-title":"Am J Med"},{"key":"2026020203355523000_ejhfhfp206-bib-0038","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejheart.2006.07.002","article-title":"A change in N-terminal pro-brain natriuretic peptide is predictive of outcome in patients with advanced heart failure","volume":"9","author":"Gardner","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2026020203355523000_ejhfhfp206-bib-0039","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1373\/clinchem.2008.108928","article-title":"Only large reductions in concentrations of natriuretic peptides (BNP and NT-proBNP) are associated with improved outcome in ambulatory patients with chronic heart failure","volume":"55","author":"Miller","year":"2009","journal-title":"Clin Chem"},{"key":"2026020203355523000_ejhfhfp206-bib-0040","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jacc.2008.04.069","article-title":"Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan heart failure trial)","volume":"52","author":"Masson","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0041","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ejheart.2007.05.007","article-title":"The role of plasma biomarkers in acute heart failure. Serial changes and independent prognostic value of NT-proBNP and cardiac troponin-T","volume":"9","author":"Metra","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2026020203355523000_ejhfhfp206-bib-0042","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/eurjhf\/hfp003","article-title":"The prognostic value of repeated measurement of N-terminal pro-B-type natriuretic peptide in patients with chronic heart failure due to left ventricular systolic dysfunction","volume":"11","author":"Kub\u00e1nek","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026020203355523000_ejhfhfp206-bib-0043","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jacc.2008.04.036","article-title":"Predicting the long-term effects of cardiac resynchronization therapy on mortality from baseline variables and the early response a report from the CARE-HF (cardiac resynchronization in heart failure) trial","volume":"52","author":"Cleland","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026020203355523000_ejhfhfp206-bib-0044","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ejheart.2007.07.010","article-title":"Prognostic importance of plasma NT-pro BNP in chronic heart failure in patients treated with a beta-blocker: results from the Carvedilol Or Metoprolol European Trial (COMET)","volume":"9","author":"Olsson","year":"2007","journal-title":"Eur J Heart Fail"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfp206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfp206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1093\/eurjhf\/hfp206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1093\/eurjhf\/hfp206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/12\/4\/338\/66522882\/eurjhf_12_4_338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/12\/4\/338\/66522882\/eurjhf_12_4_338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:36:09Z","timestamp":1770021369000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/12\/4\/338\/8435966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,24]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,3,24]]},"published-print":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfp206","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,4]]},"published":{"date-parts":[[2010,3,24]]}}}