{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:14:25Z","timestamp":1793225665465,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess adherence to medical treatment in patients with heart failure (HF) using a specific questionnaire and measurement of the serum concentration of digoxin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Forty patients with symptomatic HF and a clinical indication for digoxin were included in this pilot study. The assessment of adherence to the medical regime was based on two different methods: (i) the CARDIA-Questionnaire and (ii) the measurement of serum digoxin concentration (SDC) at 1 and 6 months. All patients were placed on digoxin treatment (target SDC 0.6\u20130.8 ng\/mL) at baseline. Poor adherence was defined if the patient self-reported taking \u226475% of the prescribed HF medication or had an SDC &amp;lt; 0.4 ng\/mL (subtherapeutic range) at the follow-up visits. During the entire follow-up, the proportion of patients with poor adherence was 15% as assessed by the questionnaire, 20% as assessed by the SDC, and 25% if both methods were combined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although HF is a symptomatic disease, the proportion of patients with poor adherence to the medical regime in our study was high (up to 25%). The objective methodology based on the measurement of the SDC identified a higher number of patients with poor adherence when compared with the CARDIA-Questionnaire.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfq015","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T20:49:46Z","timestamp":1266612586000},"page":"389-396","source":"Crossref","is-referenced-by-count":23,"title":["Adherence to the Medical Regime in Patients with Heart Failure"],"prefix":"10.1093","volume":"12","author":[{"given":"Stefano","family":"Muzzarelli","sequence":"first","affiliation":[{"name":"Cardiology Department, University Hospital Basel , Petersgraben 4, CH-4031, Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Brunner-La Rocca","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Maastricht , P. Debyelaan 25, NL-6202, AZ, Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otmar","family":"Pfister","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Basel , Petersgraben 4, CH-4031, Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Foglia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Regional Hospital of Locarno , Via all'Ospedale 1, CH-6600, Locarno ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Moschovitis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Regional Hospital of Lugano , Via Tesserete, CH-6900, Lugano ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Mombelli","sequence":"additional","affiliation":[{"name":"Department of 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