{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:28:04Z","timestamp":1770067684839,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A left ventricular end-systolic volume (LVESV) \u226560 mL\/m2 has been shown to be associated with increased cardiac mortality after a reperfused myocardial infarction (MI). The reduction in LVESV following surgical ventricular reconstruction (SVR) is reported to be between 19% and 50% but its impact on prognosis is not well-established. The aim of this study was therefore to assess the impact on survival of a residual LVESV index (LVESVI) of \u2265 or &amp;lt;60 mL\/m2 following SVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>All patients undergoing SVR at our Centre between July 2001 and March 2009 were eligible to be included in this study if they had a preoperative LVESVI of \u226560 mL\/m2 and an LVESVI measurement performed at discharge (7\u201310 days after surgery). Two hundred and sixteen patients (aged 64 \u00b1 9 years, 33 women) satisfied these criteria. Coronary artery bypass graft was performed in 197 patients (91.2%) and mitral repair in 63 patients (29%). Left ventricular ESVI had decreased by 41% at discharge in the overall population. Patients were grouped according to the residual LVESVI at discharge as follows: Group 1, LVESVI \u2265 60 mL\/m2 (n = 71), and Group 2, LVESVI &amp;lt; 60 mL\/m2 (n = 145). In both groups, LVESVI decreased significantly with respect to baseline, by 29% in Group 1 and by 47% in Group 2. At multivariate analysis, the presence of a non-Q-wave MI and a preoperative internal diastolic diameter of 65 mm were the strongest predictors of a residual post-operative LVESVI of \u226560 mL\/m2. Risk of all-cause death was significantly higher in Group 1. Post-operative LVESVI of \u226560 mL\/m2 was an independent predictor of mortality at follow-up [Exp(B) = 10.7, CI: 2.67\u201342.9, P = 0.001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings confirm the role of LVESVI in predicting survival following SVR; the lack of additional improvement in survival with SVR observed in the STICH trial might be due to the inadequate volume reduction (\u221219%).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfq020","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T20:26:07Z","timestamp":1267129567000},"page":"375-381","source":"Crossref","is-referenced-by-count":84,"title":["End-Systolic Volume Following Surgical Ventricular Reconstruction Impacts Survival in Patients with Ischaemic Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"12","author":[{"given":"Marisa","family":"Di Donato","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, University of Florence , Florence ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serenella","family":"Castelvecchio","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS, San Donato Hospital , Via Morandi 30, San Donato Milanese, 20097, Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Menicanti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS, San Donato Hospital , Via Morandi 30, San Donato Milanese, 20097, Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,3,24]]},"reference":[{"key":"2026020203355692200_ejhfhfq020-bib-0001","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.76.1.44","article-title":"Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction","volume":"76","author":"White","year":"1987","journal-title":"Circulation"},{"key":"2026020203355692200_ejhfhfq020-bib-0002","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.CIR.96.1.116","article-title":"End-systolic volume index at 90 to 180 min into reperfusion therapy for acute myocardial infarction is a strong predictor of early and late mortality. 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