{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:06:19Z","timestamp":1791295579085,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine the relationship between galectin-3 concentrations and cardiac structure in patients with acute dyspnoea, and to evaluate the impact of galectin-3 independent of echocardiographic measurements on long-term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>One hundred and fifteen patients presenting to the emergency department with acute dyspnoea who had galectin-3 levels and detailed echocardiographic studies on admission were studied. Galectin-3 levels were associated with older age (r = 0.26, P = 0.006), lower creatinine clearance (r = \u22120.42, P &amp;lt; 0.001), and higher levels of N-terminal-proBNP (r = 0.39, P &amp;lt; 0.001). Higher galectin-3 levels were associated with tissue Doppler E\/Ea ratio (r = 0.35, P = 0.01), a lower right ventricular (RV) fractional area change (r = \u22120.19, P = 0.05), higher RV systolic pressure (r = 0.37, P &amp;lt; 0.001), and more severe mitral (r = 0.30, P = 0.001) or tricuspid regurgitation (r = 0.26, P = 0.005). In patients diagnosed with heart failure (HF), the association between galectin-3 and valvular regurgitation and RV systolic pressure persisted. In a multivariate Cox regression model, galectin-3 remained a significant predictor of 4-year mortality independent of echocardiographic markers of risk. Dyspnoeic patients with HF and galectin-3 levels above the median value had a 63% mortality; patients less than the median value had a 37% mortality (P = 0.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among dyspnoeic patients with and without ADHF, galectin-3 concentrations are associated with echocardiographic markers of ventricular function. In patients with ADHF, a single admission galectin-3 level predicts mortality to 4 years, independent of echocardiographic markers of disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfq091","type":"journal-article","created":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T20:26:19Z","timestamp":1275769579000},"page":"826-832","source":"Crossref","is-referenced-by-count":280,"title":["Galectin-3, Cardiac Structure and Function, and Long-Term Mortality in Patients with Acutely Decompensated Heart Failure"],"prefix":"10.1093","volume":"12","author":[{"given":"Ravi V.","family":"Shah","sequence":"first","affiliation":[{"name":"Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School , 32 Fruit Street, Yawkey 5984, Boston, MA, 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel A.","family":"Chen-Tournoux","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School , 32 Fruit Street, Yawkey 5984, Boston, MA, 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Picard","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School , 32 Fruit Street, Yawkey 5984, Boston, MA, 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland R. 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