{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:42:33Z","timestamp":1792446153855,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In patients with heart failure (HF), the use of diuretics may be a double-edged sword that can alleviate symptoms of congestion, but also result in over-diuresis and intravascular volume depletion. The purpose of the present study was to examine plasma volume (PV) in HF patients receiving from 0 to 160 mg of furosemide and to investigate whether determination of plasma N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) concentrations can predict PV-status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Plasma volume, extracellular volume, glomerular filtration rate, NT-proBNP, and daily renal sodium excretion were measured in 18 patients with medically treated, compensated HF and in 27 healthy volunteers. Cardiac function was examined by non-invasive cardiac output determination and echocardiography. Exercise capacity was evaluated by 6 min walk test. There was a borderline significant difference in PV between patients with HF and control subjects (37.3 \u00b1 6.0 and 40.2 \u00b1 5.8 mL\/kg, respectively, P = 0.092) with a significant tendency towards a contraction of PV with increasing use of diuretics (P = 0.031). There was no difference in extracellular volume between patients with HF and control subjects (P = 0.844). NT-proBNP plasma concentrations had no correlation to either sodium excretion (P = 0.193) or PV (P = 0.471) in patients with HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma volume in patients with HF was within normal limits, but patients treated with high doses of loop-diuretics tended to have subnormal PV. Single measurement of NT-proBNP plasma concentration could not be used to estimate intravascular volume status in patients with HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfq100","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T20:32:12Z","timestamp":1278621132000},"page":"995-1001","source":"Crossref","is-referenced-by-count":36,"title":["Impact of Diuretic Treatment and Sodium Intake on Plasma Volume in Patients with Compensated Systolic Heart Failure"],"prefix":"10.1093","volume":"12","author":[{"given":"Peter K.","family":"Bonfils","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Koege Hospital , Lykkebaekvej 1, DK-4600, Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Damgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Taskiran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Koege Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter","family":"Goetze","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Norsk","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Gadsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Medicine, Koege Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"2026020203344641300_ejhfhfq100-bib-0001","first-page":"CD003838","article-title":"Diuretics for heart failure","volume":"1","author":"Faris","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"2026020203344641300_ejhfhfq100-bib-0002","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1097\/01.CCM.0000296272.68078.6B","article-title":"Diuretics: still the mainstay of treatment","volume":"36","author":"Wang","year":"2008","journal-title":"Crit Care Med"},{"key":"2026020203344641300_ejhfhfq100-bib-0003","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/CIRCHEARTFAILURE.108.821785","article-title":"Loop diuretics in acute decompensated heart failure: necessary? Evil? A necessary evil?","volume":"2","author":"Felker","year":"2009","journal-title":"Circ Heart Fail"},{"key":"2026020203344641300_ejhfhfq100-bib-0004","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11936-007-0028-z","article-title":"Optimal use of diuretics in patients with heart failure","volume":"9","author":"Patel","year":"2007","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"2026020203344641300_ejhfhfq100-bib-0005","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1161\/01.CIR.80.2.299","article-title":"Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure","volume":"80","author":"Anand","year":"1989","journal-title":"Circulation"},{"key":"2026020203344641300_ejhfhfq100-bib-0006","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ahj.2005.07.031","article-title":"Blood volume and brain natriuretic peptide in congestive heart failure: a pilot study","volume":"150","author":"James","year":"2005","journal-title":"Am Heart J"},{"key":"2026020203344641300_ejhfhfq100-bib-0007","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0735-1097(99)00530-6","article-title":"Contracted plasma and blood volume in chronic heart failure","volume":"35","author":"Feigenbaum","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2026020203344641300_ejhfhfq100-bib-0008","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/S0735-1097(02)01903-4","article-title":"The regulation and measurement of plasma volume in heart failure","volume":"39","author":"Kalra","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026020203344641300_ejhfhfq100-bib-0009","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000006965","article-title":"Pearls and pitfalls in the use and abuse of diuretics for chronic congestive heart failure","volume":"92","author":"Constant","year":"1999","journal-title":"Cardiology"},{"key":"2026020203344641300_ejhfhfq100-bib-0010","doi-asserted-by":"crossref","first-page":"R1294","DOI":"10.1152\/ajpregu.00738.2005","article-title":"Hemodynamic and neuroendocrine responses to changes in sodium intake in compensated heart failure","volume":"290","author":"Damgaard","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2026020203344641300_ejhfhfq100-bib-0011","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/cs1020247","article-title":"Non-invasive measurement of cardiac output in heart failure patients using a new foreign gas rebreathing technique","volume":"102","author":"Gabrielsen","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"2026020203344641300_ejhfhfq100-bib-0012","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","volume":"166","author":"ATS statement: guidelines for the six-minute walk test","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020203344641300_ejhfhfq100-bib-0013","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ejheart.2003.11.024","article-title":"The 6 min walking test in chronic heart failure: indications, interpretation and limitations from a review of the literature","volume":"6","author":"Faggiano","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"2026020203344641300_ejhfhfq100-bib-0014","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.RES.32.5.643","article-title":"Transcapillary escape rate of albumin and plasma volume in essential hypertension","volume":"32","author":"Parving","year":"1973","journal-title":"Circ Res"},{"key":"2026020203344641300_ejhfhfq100-bib-0015","first-page":"793","volume":"21","author":"Recommended methods for measurement of red-cell and plasma volume: International Committee for Standardization in Haematology","year":"1980","journal-title":"J Nucl Med"},{"key":"2026020203344641300_ejhfhfq100-bib-0016","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3109\/00365518009091966","article-title":"A simple single injection method for determination of the extracellular fluid volume","volume":"40","author":"Brochner-Mortensen","year":"1980","journal-title":"Scand J Clin Lab Invest"},{"key":"2026020203344641300_ejhfhfq100-bib-0017","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1373\/clinchem.2004.038281","article-title":"Analytical performance and diagnostic accuracy of immunometric assays for the measurement of plasma B-type natriuretic peptide (BNP) and N-terminal proBNP","volume":"51","author":"Clerico","year":"2005","journal-title":"Clin Chem"},{"key":"2026020203344641300_ejhfhfq100-bib-0018","doi-asserted-by":"crossref","first-page":"F585","DOI":"10.1152\/ajprenal.2000.278.4.F585","article-title":"High dietary sodium chloride consumption may not induce body fluid retention in humans","volume":"278","author":"Heer","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"2026020203344641300_ejhfhfq100-bib-0019","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1527-5299.2002.00700.x","article-title":"Balancing diuretic therapy in heart failure: loop diuretics, thiazides, and aldosterone antagonists","volume":"8","author":"Paul","year":"2002","journal-title":"Congest Heart Fail"},{"key":"2026020203344641300_ejhfhfq100-bib-0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1067\/mhj.2003.166","article-title":"Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus in refractory congestive heart failure: long-term effects","volume":"145","author":"Licata","year":"2003","journal-title":"Am Heart J"},{"key":"2026020203344641300_ejhfhfq100-bib-0021","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1388-9842(00)00094-5","article-title":"Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure","volume":"2","author":"Paterna","year":"2000","journal-title":"Eur J Heart Fail"},{"key":"2026020203344641300_ejhfhfq100-bib-0022","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/CS20070193","article-title":"Normal-sodium diet compared with low-sodium diet in compensated congestive heart failure: is sodium an old enemy or a new friend?","volume":"114","author":"Paterna","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"2026020203344641300_ejhfhfq100-bib-0023","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.amjcard.2007.11.027","article-title":"Outpatient monitoring and treatment of chronic heart failure guided by amino-terminal pro-B-type natriuretic peptide measurement","volume":"101","author":"Troughton","year":"2008","journal-title":"Am J Cardiol"},{"key":"2026020203344641300_ejhfhfq100-bib-0024","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ahj.2009.06.018","article-title":"Biomarker-guided therapy in chronic heart failure: a meta-analysis of randomized controlled trials","volume":"158","author":"Felker","year":"2009","journal-title":"Am Heart J"},{"key":"2026020203344641300_ejhfhfq100-bib-0025","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1093\/eurheartj\/ehm396","article-title":"Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure","volume":"28","author":"Damgaard","year":"2007","journal-title":"Eur Heart J"},{"key":"2026020203344641300_ejhfhfq100-bib-0026","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1373\/clinchem.2004.034272","article-title":"Biochemistry of pro-B-type natriuretic peptide-derived peptides: the endocrine heart revisited","volume":"50","author":"Goetze","year":"2004","journal-title":"Clin Chem"},{"key":"2026020203344641300_ejhfhfq100-bib-0027","first-page":"H1684","article-title":"Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure","volume":"274","author":"Luchner","year":"1998","journal-title":"Am J Physiol"},{"key":"2026020203344641300_ejhfhfq100-bib-0028","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1093\/eurheartj\/ehl109","article-title":"Atrial secretion of B-type natriuretic peptide","volume":"27","author":"Goetze","year":"2006","journal-title":"Eur Heart J"},{"key":"2026020203344641300_ejhfhfq100-bib-0029","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jacc.2009.02.095","article-title":"N-terminal pro B-type natriuretic peptide-guided treatment for chronic heart failure: Results from the BATTLESCARRED (NT-proBNP assisted treatment to lessen serial cardiac readmissions and death) trial","volume":"55","author":"Lainchbury","year":"2010","journal-title":"J Am Coll Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfq100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/12\/9\/995\/66522582\/eurjhf_12_9_995.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/12\/9\/995\/66522582\/eurjhf_12_9_995.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:34:56Z","timestamp":1770021296000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/12\/9\/995\/8435905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,1]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,1,13]]},"published-print":{"date-parts":[[2010,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfq100","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,9]]},"published":{"date-parts":[[2010,9,1]]}}}