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The present position statement offers a state-of-the-art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM. A high index of suspicion is required for the diagnosis, as shortness of breath and ankle swelling are common in the peripartum period. Peripartum cardiomyopathy is a distinct form of cardiomyopathy, associated with a high morbidity and mortality, but also with the possibility of full recovery. Oxidative stress and the generation of a cardiotoxic subfragment of prolactin may play key roles in the pathophysiology of PPCM. In this regard, pharmacological blockade of prolactin offers the possibility of a disease-specific therapy.<\/jats:p>","DOI":"10.1093\/eurjhf\/hfq120","type":"journal-article","created":{"date-parts":[[2010,7,31]],"date-time":"2010-07-31T12:37:41Z","timestamp":1280579861000},"page":"767-778","source":"Crossref","is-referenced-by-count":909,"title":["Current State of Knowledge on Aetiology, Diagnosis, Management, and Therapy of Peripartum Cardiomyopathy: A Position Statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy"],"prefix":"10.1093","volume":"12","author":[{"given":"Karen","family":"Sliwa","sequence":"first","affiliation":[{"name":"Hatter Cardiovascular Research Institute, University of Cape Town , Cape Town ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Hilfiker-Kleiner","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and 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