{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:57:22Z","timestamp":1781769442059,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to determine the relationship between improved ejection fraction (EF) and occurrence of arrhythmias in patients with cardiac resynchronization therapy devices with defibrillator function (CRT-D). The hypothesis was that patients who experienced a marked improvement in EF also had fewer appropriate defibrillator interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed data of 270 patients from2 prospective registries with follow-up of \u226512 months and echocardiography performed \u22658 months after CRT-D implantation. The discriminator was whether left ventricular ejection fraction (LVEF) improved to &amp;gt;35% [cut-off for primary prevention implantable cardioverter-defibrillator (ICD) implantation]. Mean age was 61 \u00b1 11 years, LVEF 22 \u00b1 5%, and follow-up 40 \u00b1 22 months. Ischaemic cardiomyopathy was present in 48%, and secondary prevention indication was present in 25%. Implantable cardioverter-defibrillator interventions were delivered to 35% of patients. Echocardiography (20 \u00b1 15 months after implantation) showed an improvement in LVEF from 22% (SD 5.4%) to 30% (SD 9.8%). Improvement to &amp;gt;35% was seen in 21% of patients. Those who improved to &amp;gt;35% had fewer ICD interventions than those who did not (23 vs.38%; P-value 0.03). Analysing only patients with a primary prevention indication and stratifying again in patients with and without improvement of LVEF to &amp;gt;35%, the latter had highly significant more ICD-therapies (6 vs. 31%; P-value 0.0008).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with CRT-D for primary prevention, whose LVEF improved to &amp;gt;35% during mid-term follow-up, are at low risk of first ICD therapies beyond year 1. If similar findings are reported in other patient cohorts, this might impact on decision-making at the time of battery depletion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfq171","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T17:18:30Z","timestamp":1287422310000},"page":"1325-1332","source":"Crossref","is-referenced-by-count":37,"title":["Close Connection between Improvement in Left Ventricular Function by Cardiac Resynchronization Therapy and the Incidence of Arrhythmias in Cardiac Resynchronization Therapy-Defibrillator Patients"],"prefix":"10.1093","volume":"12","author":[{"given":"Beat A.","family":"Schaer","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Basel Hospital , Petersgraben 4, 4031, Basel ,","place":["Switzerland"]},{"name":"Department of Cardiology, Thoraxcenter, Erasmus Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Basel Hospital , Petersgraben 4, 4031, Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Di Valentino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Basel Hospital , Petersgraben 4, 4031, Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama I.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Erasmus Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sticherling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Basel Hospital , Petersgraben 4, 4031, Basel 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