{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:49:06Z","timestamp":1770058146760,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Low-dose epoetin-\u03b2 improved neo-angiogenesis and cardiac regeneration in experimental models of ischaemic cardiomyopathy without raising haemoglobin. No clinical study has tested this approach to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We performed a randomized, placebo-controlled, double-blind, single-centre study of 35 IU\/kg body weight epoetin-\u03b2 given subcutaneously once weekly for 6 months started within 3 weeks after successful percutaneous coronary intervention (PCI). Patients were included if they presented with a lesion within the proximal segment of the left anterior descending artery, the right coronary artery, or circumflex and had symptomatic heart failure. Patients with ST-segment elevation due to an acute myocardial infarct were excluded. The outcome variables were measured at baseline and at 6 months. Primary outcome measure was individual change in ejection fraction; secondary outcome was safety, change in N-terminal pro-brain natriuretic peptide, and peak VO2. Twenty-four patients completed the 6-month treatment course. No adverse event related to the treatment occurred. Low-dose epoetin-\u03b2 following PCI significantly improved global ejection fraction as measured by echocardiography (EPO: \u0394EF 5.2 \u00b1 2.0%, P= 0.013; placebo: \u0394EF 0.3 \u00b1 1.6%, P= 0.851; P= 0.019 for the inter-group difference) and cardiac magnetic resonance (EPO: \u0394EF 3.1 \u00b1 1.6%, P= 0.124; placebo: \u22121.9 \u00b1 1.2%, P= 0.167; P= 0.042 for the inter-group difference). N-terminal pro-brain natriuretic peptide levels decreased in both groups without significant inter-group differences. Peak VO2 levels increased significantly by 3.9 \u00b1 1.1% (P&amp;lt; 0.05) in the EPO group, whereas in the placebo group the increase did not reach statistical significance (\u0394peak VO2 3.0 \u00b1 1.6, P = ns). No significant difference regarding peak VO2 was observed between the EPO and placebo groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low-dose epoetin-\u03b2 treatment following PCI is safe and feasible, and has possible beneficial effects on global ejection fraction and measures of exercise capacity. Extended low-dose epoetin-\u03b2 treatment warrants further mechanistic studies as well as larger clinical trials.<\/jats:p>\n                    <jats:p>Clinical Trial Registration Information: NCT00568542<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfr002","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T12:32:46Z","timestamp":1303216366000},"page":"560-568","source":"Crossref","is-referenced-by-count":19,"title":["A Pilot Study of Chronic, Low-Dose Epoetin-\u03b2 Following Percutaneous Coronary Intervention Suggests Safety, Feasibility, and Efficacy in Patients with Symptomatic Ischaemic Heart Failure"],"prefix":"10.1093","volume":"13","author":[{"given":"Martin W.","family":"Bergmann","sequence":"first","affiliation":[{"name":"Franz-Volhard Clinic, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]},{"name":"Franz-Volhard Clinical Research Center, Experimental and Clinical Research Center, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Haufe","sequence":"additional","affiliation":[{"name":"Franz-Volhard Clinical Research Center, Experimental and Clinical Research Center, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"von Knobelsdorff-Brenkenhoff","sequence":"additional","affiliation":[{"name":"Franz-Volhard Clinic, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun","family":"Mehling","sequence":"additional","affiliation":[{"name":"Franz-Volhard Clinical Research Center, Experimental and Clinical Research Center, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Wa\u00dfmuth","sequence":"additional","affiliation":[{"name":"Franz-Volhard Clinic, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"M\u00fcnch","sequence":"additional","affiliation":[{"name":"HealthTwist GmbH , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Busjahn","sequence":"additional","affiliation":[{"name":"HealthTwist GmbH , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Schulz-Menger","sequence":"additional","affiliation":[{"name":"Franz-Volhard Clinic, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Jordan","sequence":"additional","affiliation":[{"name":"Franz-Volhard Clinical Research Center, Experimental and Clinical Research Center, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich C.","family":"Luft","sequence":"additional","affiliation":[{"name":"Franz-Volhard Clinic, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]},{"name":"Franz-Volhard Clinical Research Center, Experimental and Clinical Research Center, Charit\u00e9 Campus Buch , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Dietz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Campus Buch & Campus Virchow , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026020203301580200_ejhfhfr002-bib-0001","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/eurheartj\/ehn309","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008","volume":"29","author":"Dickstein","year":"2008","journal-title":"Eur Heart J"},{"key":"2026020203301580200_ejhfhfr002-bib-0002","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1172\/JCI200524283","article-title":"Unchain my heart: the scientific foundations of cardiac repair","volume":"115","author":"Dimmeler","year":"2005","journal-title":"J Clin Invest"},{"key":"2026020203301580200_ejhfhfr002-bib-0003","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1056\/NEJMoa060186","article-title":"Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction","volume":"355","author":"Schachinger","year":"2006","journal-title":"N Engl J Med"},{"key":"2026020203301580200_ejhfhfr002-bib-0004","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/eurheartj\/ehp073","article-title":"Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) trial","volume":"30","author":"Tendera","year":"2009","journal-title":"Eur Heart J"},{"key":"2026020203301580200_ejhfhfr002-bib-0005","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jacc.2007.11.073","article-title":"Stem cell mobilization by granulocyte colony-stimulating factor for myocardial recovery after acute myocardial infarction: a meta-analysis","volume":"51","author":"Zohlnhofer","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026020203301580200_ejhfhfr002-bib-0006","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1093\/eurheartj\/ehq304","article-title":"A single dose of erythropoietin in ST-elevation myocardial infarction","volume":"31","author":"Voors","year":"2010","journal-title":"Eur Heart J"},{"key":"2026020203301580200_ejhfhfr002-bib-0007","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jacc.2006.11.024","article-title":"Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial","volume":"49","author":"Ponikowski","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026020203301580200_ejhfhfr002-bib-0008","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.ahj.2006.08.005","article-title":"Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia","volume":"152","author":"Palazzuoli","year":"2006","journal-title":"Am Heart J"},{"key":"2026020203301580200_ejhfhfr002-bib-0009","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa062276","article-title":"Normalization of hemoglobin level in patients with chronic kidney disease and anemia","volume":"355","author":"Drueke","year":"2006","journal-title":"N Engl J Med"},{"key":"2026020203301580200_ejhfhfr002-bib-0010","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa065485","article-title":"Correction of anemia with Epoetin alfa in chronic kidney disease","volume":"355","author":"Singh","year":"2006","journal-title":"N Engl J Med"},{"key":"2026020203301580200_ejhfhfr002-bib-0011","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ki.2009.415","article-title":"A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment","volume":"77","author":"Szczech","year":"2010","journal-title":"Kidney Int"},{"key":"2026020203301580200_ejhfhfr002-bib-0012","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejheart.2007.10.008","article-title":"Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit","volume":"10","author":"Lipsic","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026020203301580200_ejhfhfr002-bib-0013","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/eurheartj\/ehm177","article-title":"Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization","volume":"28","author":"Westenbrink","year":"2007","journal-title":"Eur Heart J"},{"key":"2026020203301580200_ejhfhfr002-bib-0014","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/eurjhf\/hfq008","article-title":"Should erythropoietin treatment in chronic heart failure be haemoglobin targeted?","volume":"12","author":"Kleijn","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026020203301580200_ejhfhfr002-bib-0015","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1182\/blood-2003-04-1284","article-title":"Erythropoietin regulates endothelial progenitor cells","volume":"103","author":"Bahlmann","year":"2004","journal-title":"Blood"},{"key":"2026020203301580200_ejhfhfr002-bib-0016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10557-008-6094-y","article-title":"Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia","volume":"22","author":"Westenbrink","year":"2008","journal-title":"Cardiovasc Drugs Ther"},{"key":"2026020203301580200_ejhfhfr002-bib-0017","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1510\/icvts.2008.191916","article-title":"Single high-dose intramyocardial administration of erythropoietin promotes early intracardiac proliferation, proves safety and restores cardiac performance after myocardial infarction in rats","volume":"9","author":"Gabel","year":"2009","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2026020203301580200_ejhfhfr002-bib-0018","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/eurjhf\/hfp098","article-title":"Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbidity-mortality trial","volume":"11","author":"McMurray","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026020203301580200_ejhfhfr002-bib-0019","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ahj.2004.08.039","article-title":"Prevalence of anemia and effects on mortality in patients with heart failure","volume":"149","author":"Lindenfeld","year":"2005","journal-title":"Am Heart J"},{"key":"2026020203301580200_ejhfhfr002-bib-0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cardfail.2008.10.024","article-title":"The potential role of erythropoietin in chronic heart failure: from the correction of anemia to improved perfusion and reduced apoptosis?","volume":"15","author":"Timmer","year":"2009","journal-title":"J Card Fail"},{"key":"2026020203301580200_ejhfhfr002-bib-0021","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000142723","article-title":"Chronic erythropoietin treatment decreases post-infarct myocardial damage in rats without venous thrombogenic effect","volume":"112","author":"Prunier","year":"2009","journal-title":"Cardiology"},{"key":"2026020203301580200_ejhfhfr002-bib-0022","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/01.RES.0000137877.89448.78","article-title":"Endothelial progenitor cells: characterization and role in vascular biology","volume":"95","author":"Urbich","year":"2004","journal-title":"Circ Res"},{"key":"2026020203301580200_ejhfhfr002-bib-0023","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10557-006-7680-5","article-title":"A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study","volume":"20","author":"Lipsic","year":"2006","journal-title":"Cardiovasc Drugs Ther"},{"key":"2026020203301580200_ejhfhfr002-bib-0024","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/eurheartj\/ehl044","article-title":"Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathy","volume":"27","author":"Hamed","year":"2006","journal-title":"Eur Heart J"},{"key":"2026020203301580200_ejhfhfr002-bib-0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/cvr\/cvm037","article-title":"Pressure-induced cardiac overload induces upregulation of endothelial and myocardial progenitor cells","volume":"77","author":"Muller","year":"2008","journal-title":"Cardiovasc Res"},{"key":"2026020203301580200_ejhfhfr002-bib-0026","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J Clin Invest"},{"key":"2026020203301580200_ejhfhfr002-bib-0027","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.stem.2008.10.017","article-title":"Differential mobilization of subsets of progenitor cells from the bone marrow","volume":"4","author":"Pitchford","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2026020203301580200_ejhfhfr002-bib-0028","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/jama.295.9.1003","article-title":"Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial","volume":"295","author":"Zohlnhofer","year":"2006","journal-title":"JAMA"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfr002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/13\/5\/560\/66469773\/eurjhf_13_5_560.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/13\/5\/560\/66469773\/eurjhf_13_5_560.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:30:27Z","timestamp":1770021027000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/13\/5\/560\/8430936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,1]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,2,18]]},"published-print":{"date-parts":[[2011,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfr002","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,5]]},"published":{"date-parts":[[2011,5,1]]}}}