{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:39:48Z","timestamp":1770061188166,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine independent associations of diabetes mellitus with outcomes in a propensity-matched cohort of patients with acute myocardial infarction (AMI) and systolic heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) trial, hospitalized AMI patients complicated by left ventricular ejection fraction \u226440% and symptoms of HF receiving standard therapy were randomized 3\u201314 days post-AMI to receive eplerenone 25\u201350 mg\/day (n = 3319) or placebo (n = 3313). Of the 6632 patients, 2142 (32%) had a history of diabetes, who were older and sicker. Using propensity scores for diabetes, we assembled a cohort of 1119 pairs of patients with and without diabetes who were balanced on 64 baseline characteristics. Incident fatal or nonfatal recurrent AMI occurred in 136 (12%) and 87 (8%) of matched patients with and without diabetes, respectively, during 2.5 years of follow-up [hazard ratio (HR) when diabetes was compared with no-diabetes, 1.61; 95% confidence interval (CI), 1.23\u20132.10; P = 0.001]. Diabetes was associated with nonfatal AMI (HR, 1.68; 95% CI, 1.23\u20132.31; P = 0.001) but not with fatal AMI (HR, 1.42; 95% CI, 0.88\u20132.28; P = 0.146). Hazard ratios (95% CIs) for the association of diabetes with all-cause mortality, cardiovascular mortality, all-cause hospitalization, and cardiovascular hospitalization were 1.12 (0.93\u20131.37; P = 0.224), 1.11 (0.90\u20131.37; P = 0.318), 1.13 (1.00\u20131.27; P = 0.054), and 1.20 (1.01\u20131.44; P = 0.042), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In post-AMI patients with systolic HF, diabetes mellitus is a significant independent risk factor for recurrent short-term nonfatal AMI, but had no association with fatal AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfr009","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T20:24:36Z","timestamp":1299788676000},"page":"551-559","source":"Crossref","is-referenced-by-count":35,"title":["Impact of Diabetes Mellitus on Outcomes in Patients with Acute Myocardial Infarction and Systolic Heart Failure"],"prefix":"10.1093","volume":"13","author":[{"given":"Prakash C.","family":"Deedwania","sequence":"first","affiliation":[{"name":"Veterans Affairs Central California Health Care System , Fresno, CA ,","place":["USA"]},{"name":"University of California San Francisco School of Medicine, Fresno , San Francisco, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa I.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Feller","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada B.","family":"Aban","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Love","sequence":"additional","affiliation":[{"name":"Case Western Reserve University , Cleveland, OH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertram","family":"Pitt","sequence":"additional","affiliation":[{"name":"University of Michigan , Ann Arbor, MI ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]},{"name":"Veterans Affairs Medical Center , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026020203301538600_ejhfhfr009-bib-0001","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1053\/euhj.1999.1530","article-title":"Accelerating impact of diabetes mellitus on mortality in the years following an acute myocardial infarction. 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