{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:27:13Z","timestamp":1782307633197,"version":"3.54.5"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate levels of vitamin D and parathyroid hormone (PTH) in a population of heart failure (HF) patients, and to evaluate whether vitamin D and PTH are related to prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This was a prospective study of 148 HF outpatients (mean age 68 years, 102 men) with follow-up for mortality after 3\u00bd years. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), PTH, 25-hydroxyvitamin D (25-OHD), and several other biomarkers were examined. Mortality and cardiovascular mortality were analysed in multivariable regression analyses adjusting for other independent prognostic variables. Vitamin D deficiency (\u226450 nmol\/L) was prevalent in 43% of the population; 26% had elevated PTH levels; none had primary hyperparathyroidism. We found a strong and independent significant association of both PTH and vitamin D to mortality, which was independent of other clinically important parameters [NT-proBNP, estimated glomerular filtration rate (eGFR), age, and left ventricular ejection fraction (LVEF)]. Both PTH and vitamin D were also significantly associated with all cause mortality. In an adjusted model, we found a hazard ratio of 1.9 (confidence interval 1.1\u20133.4) for vitamin D deficiency and 2.0 (1.0\u20133.8) for the upper median of PTH, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this relatively small prospective study, PTH and vitamin D were independently associated with all cause and cardiovascular mortality in patients with HF. This was independent of other known risk factors such as eGFR, LVEF, NT-proBNP, and age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfr016","type":"journal-article","created":{"date-parts":[[2011,3,18]],"date-time":"2011-03-18T00:16:44Z","timestamp":1300407404000},"page":"626-632","source":"Crossref","is-referenced-by-count":116,"title":["Parathyroid hormone and vitamin D\u2014markers for cardiovascular and all cause mortality in heart failure"],"prefix":"10.1093","volume":"13","author":[{"given":"Louise Lind","family":"Schierbeck","sequence":"first","affiliation":[{"name":"Department of Endocrinology, afsn.541, Hvidovre Hospital , Ketteg\u00e5rd alle 30, 2650, Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben Slott","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, \u00c5rhus University Hospital , \u00c5rhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, afsn.541, Hvidovre Hospital , Ketteg\u00e5rd alle 30, 2650, Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorm","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hvidovre University Hospital , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Erik Beck","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, afsn.541, Hvidovre Hospital , Ketteg\u00e5rd alle 30, 2650, Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026020203294553600_ejhfhfr016-bib-0001","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/hrt.2008.147652","article-title":"Serum intact parathyroid hormone levels predict hospitalisation for heart failure","volume":"95","author":"Sugimoto","year":"2009","journal-title":"Heart"},{"key":"2026020203294553600_ejhfhfr016-bib-0002","doi-asserted-by":"crossref","first-page":"2739S","DOI":"10.1093\/jn\/135.11.2739S","article-title":"The vitamin D epidemic and its health consequences","volume":"135","author":"Holick","year":"2005","journal-title":"J Nutr"},{"key":"2026020203294553600_ejhfhfr016-bib-0003","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1006\/cbir.1996.0081","article-title":"Immunochemical identification of the 1,25-dihydroxyvitamin D3 receptor protein in human heart","volume":"20","author":"O'Connell","year":"1996","journal-title":"Cell Biol Int"},{"key":"2026020203294553600_ejhfhfr016-bib-0004","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1210\/endo.133.2.8393771","article-title":"Parathyroid hormone (PTH)\/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues","volume":"133","author":"Urena","year":"1993","journal-title":"Endocrinology"},{"key":"2026020203294553600_ejhfhfr016-bib-0005","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000168620","article-title":"Parathyroid hormone-parathyroid hormone related protein receptor messenger RNA is present in many tissues besides the kidney","volume":"13","author":"Tian","year":"1993","journal-title":"Am J Nephrol"},{"key":"2026020203294553600_ejhfhfr016-bib-0006","first-page":"29","article-title":"[Vitamin D deficiency. Definition and prevalence in Denmark]","volume":"167","author":"Mosekilde","year":"2005","journal-title":"Ugeskr Laeger"},{"key":"2026020203294553600_ejhfhfr016-bib-0007","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.1210\/jc.2003-030604","article-title":"Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the longitudinal aging study Amsterdam","volume":"88","author":"Visser","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2026020203294553600_ejhfhfr016-bib-0008","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mam.2005.01.005","article-title":"Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone","volume":"26","author":"Montero-Odasso","year":"2005","journal-title":"Mol Aspects Med"},{"key":"2026020203294553600_ejhfhfr016-bib-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1542-4758.2007.00146.x","article-title":"Modification of cardiovascular risk in hemodialysis patients: an evidence-based review","volume":"11","author":"Johnson","year":"2007","journal-title":"Hemodial Int"},{"issue":"Suppl 5","key":"2026020203294553600_ejhfhfr016-bib-0010","doi-asserted-by":"crossref","first-page":"V2","DOI":"10.1093\/ndt\/gfh1049","article-title":"The clinical consequences of secondary hyperparathyroidism: focus on clinical outcomes","volume":"19","author":"Horl","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"2026020203294553600_ejhfhfr016-bib-0011","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1523-1755.2005.00421.x","article-title":"Pathogenesis of vascular calcification in chronic kidney disease","volume":"68","author":"Cozzolino","year":"2005","journal-title":"Kidney Int"},{"key":"2026020203294553600_ejhfhfr016-bib-0012","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00005344-200110000-00001","article-title":"Signaling pathway and chronotropic action of parathyroid hormone in isolated perfused rat heart","volume":"38","author":"Shimoyama","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026020203294553600_ejhfhfr016-bib-0013","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1161\/01.CIR.96.10.3704","article-title":"Positive chronotropic actions of parathyroid hormone and parathyroid hormone-related peptide are associated with increases in the current, I(f), and the slope of the pacemaker potential","volume":"96","author":"Hara","year":"1997","journal-title":"Circulation"},{"key":"2026020203294553600_ejhfhfr016-bib-0014","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1172\/JCI110137","article-title":"Effect of parathyroid hormone on rat heart cells","volume":"67","author":"Bogin","year":"1981","journal-title":"J Clin Invest"},{"key":"2026020203294553600_ejhfhfr016-bib-0015","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1210\/endo.136.7.7789328","article-title":"The hemodynamic basis for the cardiac effects of parathyroid hormone (PTH) and PTH-related protein","volume":"136","author":"Ogino","year":"1995","journal-title":"Endocrinology"},{"issue":"Pt 2","key":"2026020203294553600_ejhfhfr016-bib-0016","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1042\/bj3100439","article-title":"Parathyroid hormone induces protein kinase C but not adenylate cyclase in adult cardiomyocytes and regulates cyclic AMP levels via protein kinase C-dependent phosphodiesterase activity","volume":"310","author":"Schluter","year":"1995","journal-title":"Biochem J"},{"key":"2026020203294553600_ejhfhfr016-bib-0017","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00198-004-1757-4","article-title":"Vitamin D status as the major factor determining the circulating levels of parathyroid hormone: a study in normal subjects","volume":"16","author":"Pepe","year":"2005","journal-title":"Osteoporos Int"},{"key":"2026020203294553600_ejhfhfr016-bib-0018","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00198-005-1867-7","article-title":"Estimates of optimal vitamin D status","volume":"16","author":"Dawson-Hughes","year":"2005","journal-title":"Osteoporos Int"},{"issue":"Pt 2","key":"2026020203294553600_ejhfhfr016-bib-0019","first-page":"H1739","article-title":"Trophic effects of catecholamines and parathyroid hormone on adult ventricular cardiomyocytes","volume":"263","author":"Schluter","year":"1992","journal-title":"Am J Physiol"},{"key":"2026020203294553600_ejhfhfr016-bib-0020","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1097\/01.hjh.0000179764.40701.36","article-title":"Serum parathyroid hormone as a predictor of increase in systolic blood pressure in men","volume":"23","author":"Jorde","year":"2005","journal-title":"J Hypertens"},{"key":"2026020203294553600_ejhfhfr016-bib-0021","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.ehj.2003.09.010","article-title":"Parathyroid hormone and left ventricular hypertrophy","volume":"24","author":"Saleh","year":"2003","journal-title":"Eur Heart J"},{"key":"2026020203294553600_ejhfhfr016-bib-0022","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1365-2265.2006.02663.x","article-title":"Increased plasma concentrations of N-terminal pro-B-type natriuretic peptide in patients with mild primary hyperparathyroidism","volume":"65","author":"Almqvist","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026020203294553600_ejhfhfr016-bib-0023","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1067\/msy.2002.128692","article-title":"Cardiac dysfunction in mild primary hyperparathyroidism assessed by radionuclide angiography and echocardiography before and after parathyroidectomy","volume":"132","author":"Almqvist","year":"2002","journal-title":"Surgery"},{"key":"2026020203294553600_ejhfhfr016-bib-0024","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/01.hjr.0000114706.27531.01","article-title":"Serum parathyroid hormone levels predict coronary heart disease: the Tromso Study","volume":"11","author":"Kamycheva","year":"2004","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2026020203294553600_ejhfhfr016-bib-0025","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1161\/CIRCULATIONAHA.108.808733","article-title":"Plasma parathyroid hormone and the risk of cardiovascular mortality in the community","volume":"119","author":"Hagstrom","year":"2009","journal-title":"Circulation"},{"key":"2026020203294553600_ejhfhfr016-bib-0026","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/eurjhf\/hfq134","article-title":"Plasma parathyroid hormone and risk of congestive heart failure in the community","volume":"12","author":"Hagstrom","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026020203294553600_ejhfhfr016-bib-0027","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1373\/clinchem.2008.120006","article-title":"Circulating calcitriol concentrations and total mortality","volume":"55","author":"Zittermann","year":"2009","journal-title":"Clin Chem"},{"key":"2026020203294553600_ejhfhfr016-bib-0028","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/archinte.168.12.1340","article-title":"Independent Association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality","volume":"168","author":"Dobnig","year":"2008","journal-title":"Arch Intern Med"},{"key":"2026020203294553600_ejhfhfr016-bib-0029","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/archinte.168.15.1629","article-title":"25-Hydroxyvitamin D levels and the risk of mortality in the general population","volume":"168","author":"Melamed","year":"2008","journal-title":"Arch Intern Med"},{"key":"2026020203294553600_ejhfhfr016-bib-0030","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1210\/jc.2010-0638","article-title":"Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men","volume":"95","author":"Cawthon","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2026020203294553600_ejhfhfr016-bib-0031","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.ahj.2010.03.031","article-title":"Serum vitamin D and risk of secondary cardiovascular disease events in patients with stable coronary heart disease","volume":"159","author":"Grandi","year":"2010","journal-title":"Am Heart J"},{"key":"2026020203294553600_ejhfhfr016-bib-0032","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/CIRCULATIONAHA.107.706127","article-title":"Vitamin D deficiency and risk of cardiovascular disease","volume":"117","author":"Wang","year":"2008","journal-title":"Circulation"},{"key":"2026020203294553600_ejhfhfr016-bib-0033","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJM199803193381201","article-title":"Hypovitaminosis D in medical inpatients","volume":"338","author":"Thomas","year":"1998","journal-title":"N Engl J Med"},{"key":"2026020203294553600_ejhfhfr016-bib-0034","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s00198-005-1910-8","article-title":"Vitamin D, parathyroid hormone levels and bone mineral density in community-dwelling older women: the Rancho Bernardo Study","volume":"16","author":"von Muhlen","year":"2005","journal-title":"Osteoporos Int"},{"key":"2026020203294553600_ejhfhfr016-bib-0035","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bone.2010.05.002","article-title":"Age but not gender modulates the relationship between PTH and vitamin D","volume":"47","author":"Arabi","year":"2010","journal-title":"Bone"},{"key":"2026020203294553600_ejhfhfr016-bib-0036","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1210\/jc.2010-0606","article-title":"A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness","volume":"95","author":"Dong","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"2026020203294553600_ejhfhfr016-bib-0037","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1079\/BJN2001345","article-title":"Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone","volume":"86","author":"Brot","year":"2001","journal-title":"Br J Nutr"},{"key":"2026020203294553600_ejhfhfr016-bib-0038","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1001\/archinte.167.16.1730","article-title":"Vitamin D Supplementation and total mortality: a meta-analysis of randomized controlled trials","volume":"167","author":"Autier","year":"2007","journal-title":"Arch Intern Med"},{"key":"2026020203294553600_ejhfhfr016-bib-0039","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/eurjhf\/hfq112","article-title":"The vitamin D system: a crosstalk between the heart and kidney","volume":"12","author":"Cozzolino","year":"2010","journal-title":"Eur J Heart Fail"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfr016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/13\/6\/626\/66469670\/eurjhf_13_6_626.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/13\/6\/626\/66469670\/eurjhf_13_6_626.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:29:56Z","timestamp":1770020996000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/13\/6\/626\/8430911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,1]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,2,18]]},"published-print":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfr016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11767956.12859054","asserted-by":"object"}]},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,6]]},"published":{"date-parts":[[2011,6,1]]}}}