{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:49:21Z","timestamp":1770058161090,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Loop diuretics are essential for the treatment of chronic heart failure (CHF) but short-acting diuretics are reported to induce sympathetic nervous system (SNS) activation. This study was performed to compare therapeutic effects of two loop diuretics, long-acting azosemide and short-acting furosemide, using 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Twenty-two patients with New York Heart Association class II\u2013III heart failure and left ventricular dysfunction, who required treatment with a loop diuretic, were included. In this crossover study, 11 patients were randomized to azosemide treatment first and the remaining 11 patients to furosemide. Treatments were administered for 6 months and then patients were crossed over to the second treatment. 123I-MIBG scintigraphy was performed before and 6 months after the start of treatment with each loop diuretic. Early and delayed images were obtained 20 min and 4 h after administration of 123I-MIBG, respectively; and the heart\/mediastinum (H\/M) ratio and washout rate (WR) were measured. In addition, left ventricular ejection fraction (LVEF), levels of brain natriuretic peptide (BNP), and norepinephrine were measured before and 6 months after the start of treatment. No differences were observed between the two groups in terms of concomitant medication, cause of heart failure, H\/M ratio, WR, BNP, norepinephrine, or LVEF. The azosemide group exhibited a significant increase in delayed image H\/M ratio, and a significant decrease in WR and norepinephrine after the final administration compared with the furosemide group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicates that azosemide suppresses SNS activation compared with furosemide in patients with CHF, suggesting that long-acting loop diuretics may have more beneficial effects on the prognosis of CHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfr054","type":"journal-article","created":{"date-parts":[[2011,5,21]],"date-time":"2011-05-21T20:13:01Z","timestamp":1306008781000},"page":"892-898","source":"Crossref","is-referenced-by-count":18,"title":["Comparative Analysis of the Therapeutic Effects of Long-Acting and Short-Acting Loop Diuretics in the Treatment of Chronic Heart Failure Using 123I-Metaiodobenzylguanidine Scintigraphy"],"prefix":"10.1093","volume":"13","author":[{"given":"Shinji","family":"Hisatake","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Nanjo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Yamashina","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Yuzawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Namiki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Omori Medical Center , 6-11-1 Omori-nishi, ta-ku, Tokyo, 143-8541 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026020203292735300_ejhfhfr054-bib-0001","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/eurjhf\/hfq100","article-title":"Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure","volume":"12","author":"Bonfils","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026020203292735300_ejhfhfr054-bib-0002","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/eurjhf\/hfq104","article-title":"Loop diuretic therapy in left ventricular systolic dysfunction: has familiarity bred contempt for a critical but potentially nephrotoxic cardio renal therapy","volume":"12","author":"MacFadyen","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026020203292735300_ejhfhfr054-bib-0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-103-1-1","article-title":"Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis","volume":"103","author":"Francis","year":"1985","journal-title":"Ann Intern Med"},{"issue":"Supple 1","key":"2026020203292735300_ejhfhfr054-bib-0004","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1097\/00005344-200110001-00017","article-title":"Comparison of neurohumoral effects of short-acting and long-acting loop diuretics in patients with chronic congestive heart failure","volume":"38","author":"Tsutsui","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026020203292735300_ejhfhfr054-bib-0005","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cardiores.2005.05.023","article-title":"Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats","volume":"68","author":"Yoshida","year":"2005","journal-title":"Cardiovasc Res"},{"key":"2026020203292735300_ejhfhfr054-bib-0006","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1067\/mnc.2002.121471","article-title":"MIBG imaging","volume":"9","author":"Patel","year":"2002","journal-title":"J Nucl Cardiol"},{"key":"2026020203292735300_ejhfhfr054-bib-0007","first-page":"349","article-title":"Radiolabeled adrenergic neuron-blocking agents; adrenomedullary imaging with [131I] iodobenzylguanidine","volume":"21","author":"Wieland","year":"1980","journal-title":"J Nucl Med"},{"key":"2026020203292735300_ejhfhfr054-bib-0008","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/01.CIR.78.5.1192","article-title":"Abnormal I-123 metaiodobenzylguanidine myocardial washout and distribution may reflect myocardial adrenergic derangement in patients with congestive cardiomyopathy","volume":"78","author":"Henderson","year":"1988","journal-title":"Circulation"},{"key":"2026020203292735300_ejhfhfr054-bib-0009","first-page":"523","article-title":"Use of iodine-123 metaiodobenzylguanidine myocardial imaging to predict the effectiveness of beta-blocker therapy in patients with dilated cardiomyopathy","volume":"24","author":"Fukuoka","year":"1997","journal-title":"Eur J Nucl Med"},{"key":"2026020203292735300_ejhfhfr054-bib-0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/01.CIR.96.2.509","article-title":"Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction","volume":"96","author":"Tsutamoto","year":"1997","journal-title":"Circulation"},{"key":"2026020203292735300_ejhfhfr054-bib-0011","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF02089953","article-title":"Clinical and pharmacological investigations of the new saluretic azosemide","volume":"14","author":"Kr\u00fcck","year":"1978","journal-title":"Eur J Clin Pharmacol"},{"key":"2026020203292735300_ejhfhfr054-bib-0012","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0002-8703(99)70504-1","article-title":"Effects of short-acting and long-acting loop diuretics on heart rate variability in patients with chronic compensated congestive heart failure","volume":"137","author":"Tomiyama","year":"1999","journal-title":"Am Heart J"},{"key":"2026020203292735300_ejhfhfr054-bib-0013","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"key":"2026020203292735300_ejhfhfr054-bib-0014","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jacc.2004.04.059","article-title":"Furosemide and the progression of left ventricular dysfunction in experimental heart failure","volume":"44","author":"McCurley","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2026020203292735300_ejhfhfr054-bib-0015","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1161\/01.CIR.100.12.1311","article-title":"Diuretics and risk of arrhythmic death in patients with left ventricular dysfunction","volume":"100","author":"Cooper","year":"1999","journal-title":"Circulation"},{"key":"2026020203292735300_ejhfhfr054-bib-0016","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"2026020203292735300_ejhfhfr054-bib-0017","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1161\/01.HYP.35.5.1025","article-title":"Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program","volume":"35","author":"Franse","year":"2000","journal-title":"Hypertension"},{"key":"2026020203292735300_ejhfhfr054-bib-0018","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cardfail.2006.03.006","article-title":"Diuretic use, progressive heart failure, and death in patients in the DIG study","volume":"12","author":"Domanski","year":"2006","journal-title":"J Card Fail"},{"key":"2026020203292735300_ejhfhfr054-bib-0019","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1007\/s00259-004-1557-2","article-title":"Usefulness of 123I-metaiodobenzylguanidine myocardial scintigraphy for predicting the effectiveness of beta-blockers in patients with dilated cardiomyopathy from the standpoint of long-term prognosis","volume":"31","author":"Fujimoto","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2026020203292735300_ejhfhfr054-bib-0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF02990076","article-title":"Prognostic value of myocardial MIBG scintigraphy findings in patients with cardiomyopathy\u2014importance of background correction for quantification of MIBG activity","volume":"16","author":"Imamura","year":"2002","journal-title":"Ann Nucl Med"},{"key":"2026020203292735300_ejhfhfr054-bib-0021","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1067\/mhj.2001.112783","article-title":"Evaluation of beta-blocker therapy in patients with dilated cardiomyopathy\u2014Clinical meaning of iodine 123-metaiodo benzylguanidine myocardial single-photon emission computed tomography","volume":"141","author":"Yamazaki","year":"2001","journal-title":"Am Heart J"},{"key":"2026020203292735300_ejhfhfr054-bib-0022","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2967\/jnumed.107.045427","article-title":"Additive effects of spironolactone and candesartan on cardiac sympathetic nerve activity and left ventricular remodeling in patients with congestive heart failure","volume":"48","author":"Kasama","year":"2007","journal-title":"J Nucl Med"},{"key":"2026020203292735300_ejhfhfr054-bib-0023","first-page":"1140","article-title":"Evaluation of metaiodobenzylguanidine uptake by the norepinephrine, dopamine and serotonin transporters","volume":"34","author":"Glowniak","year":"1993","journal-title":"J Nucl Med"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfr054","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfr054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1093\/eurjhf\/hfr054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1093\/eurjhf\/hfr054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/13\/8\/892\/66469276\/eurjhf_13_8_892.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/13\/8\/892\/66469276\/eurjhf_13_8_892.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:29:37Z","timestamp":1770020977000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/13\/8\/892\/8430867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,1]]},"references-count":23,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,2,18]]},"published-print":{"date-parts":[[2011,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfr054","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,8]]},"published":{"date-parts":[[2011,8,1]]}}}