{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:38:23Z","timestamp":1770057503099,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article provides information and a commentary on key trials relevant to the pathophysiology, prevention, and treatment of heart failure (HF) presented at the annual American College of Cardiology meeting held in New Orleans in 2011. Unpublished reports should be considered as preliminary, since analyses may change in the final publication. The STICH trial failed to show a benefit of revascularization on all-cause mortality in patients with HF and coronary artery disease; however, cardiovascular deaths were reduced compared with medical therapy alone. Results from the NorthStar study suggest that patients with clinically stable systolic HF, who are on optimal medical therapy, including those with elevated amino-terminal B-type natriuretic peptide levels, may not benefit from long-term follow-up in an HF clinic. Results from the TARGET study demonstrate that targeted left ventricular lead placement using speckle tracking echocardiography is feasible in patients undergoing implantation of a cardiac resynchronization therapy device and is associated with an enhanced response. Two-year follow-up data from EVEREST II show that although a catheter-based mitral valve repair procedure using the MitraClip\u00ae system was less effective at reducing mitral regurgitation than conventional surgery, similar improvements in clinical outcomes were observed with fewer short-term adverse events.<\/jats:p>","DOI":"10.1093\/eurjhf\/hfr077","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T15:55:50Z","timestamp":1309276550000},"page":"805-808","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Trials Update from the American College of Cardiology Meeting 2011: STICH, NorthStar, TARGET, and EVEREST II"],"prefix":"10.1093","volume":"13","author":[{"given":"John G.F.","family":"Cleland","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, Castle Hill Hospital, University of Hull , Daisy Building, Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison P.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, Castle Hill Hospital, University of Hull , Daisy Building, Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Freemantle","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, UCL Medical School , Rowland Hill Street, London, NW3 2PF ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hull York Medical School, Castle Hill Hospital, University of Hull , Daisy Building, Cottingham, Kingston-upon-Hull, HU16 5JQ ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026020203302637700_ejhfhfr077-bib-0001","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0735-1097(02)01726-6","article-title":"Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis","volume":"39","author":"Allman","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026020203302637700_ejhfhfr077-bib-0002","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1056\/NEJM198506273122603","article-title":"A randomized trial of coronary artery bypass surgery. Survival of patients with a low ejection fraction","volume":"312","author":"Passamani","year":"1985","journal-title":"New Engl J Med"},{"key":"2026020203302637700_ejhfhfr077-bib-0003","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/eurjhf\/hfq230","article-title":"The heart failure revascularisation trail (HEART)","volume":"13","author":"Cleland","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026020203302637700_ejhfhfr077-bib-0004","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/eurjhf\/hfr075","article-title":"Revascularisation for patients with heart failure. Inconsistencies between theory and practice","volume":"13","author":"Cleland","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026020203302637700_ejhfhfr077-bib-0005","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1056\/NEJMoa1100356","article-title":"Coronary artery bypass surgery in patients with left ventricular dysfunction","volume":"364","author":"Velazquez","year":"2011","journal-title":"N Eng J Med"},{"key":"2026020203302637700_ejhfhfr077-bib-0006","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ejheart.2008.08.005","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008 The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)","volume":"10","author":"Dickstein","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026020203302637700_ejhfhfr077-bib-0007","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/eurjhf\/hfp025","article-title":"Incidence and predictors of hospitalization or death in patients managed in multidisciplinary heart failure clinics","volume":"11","author":"Gustafsson","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026020203302637700_ejhfhfr077-bib-0008","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ahj.2008.06.007","article-title":"Design and methodology of the NorthStar study: NT-proBNP stratified follow-up in outpatient heart failure clinics- a randomized Danish multicentre study","volume":"156","author":"Schou","year":"2008","journal-title":"Am Heart J"},{"key":"2026020203302637700_ejhfhfr077-bib-0009","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/hrt.2010.209171","article-title":"The national heart failure audit for England and Wales 2008\u20132009","volume":"97","author":"Cleland","year":"2011","journal-title":"Heart"},{"key":"2026020203302637700_ejhfhfr077-bib-0010","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/eurheartj\/ehl099","article-title":"Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the cardiac resynchronisation-heart failure (CARE-HF) trial extension phase]","volume":"27","author":"Cleland","year":"2006","journal-title":"Eur Heart J"},{"key":"2026020203302637700_ejhfhfr077-bib-0011","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/eurjhf\/hfp149","article-title":"Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008","volume":"11","author":"Van Veldhuisen","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026020203302637700_ejhfhfr077-bib-0012","first-page":"541","article-title":"Should we be trying to define responders to cardiac resynchronisation therapy?","volume":"3","author":"Cleland","year":"2010","journal-title":"JACC: Cardiovasc Imaging"},{"key":"2026020203302637700_ejhfhfr077-bib-0013","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jacc.2008.10.040","article-title":"Cardiac resynchronisation therapy. 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