{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:27:38Z","timestamp":1790396858828,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The maximum rate of left ventricular (LV) pressure rise (dP\/dtmax) has been used to assess the acute haemodynamic effect of cardiac resynchronization therapy (CRT). We tested the hypothesis that LV dP\/dtmax predicts long-term clinical outcome after initiation of CRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This was a retrospective observational multicentre study in 285 patients in whom dP\/dtmax was measured invasively following implantation of a CRT device. The minimum required follow-up was 1 year. We analysed the relationship between dP\/dtmax and time to the composite endpoint, consisting of all-cause mortality, heart transplantation (HTX), or LV assist device (LVAD) implantation within the first year of CRT. Thirty-four events occurred after a mean follow-up of 160 days (range 21\u2013359). Patients with an event had lower dP\/dtmax than patients without an event both at baseline (705 \u00b1 194 vs. 800 \u00b1 222 mmHg\/s, P= 0.018) and during CRT (894 \u00b1 224 vs. 985 \u00b1 244 mmHg\/s, P= 0.033), but the acute increase in dP\/dtmax was similar in patients with and without an event (190 \u00b1 133 vs. 185 \u00b1 115 mmHg\/s, P= n.s.). Left ventricular dP\/dtmax-level at baseline and during CRT both predicted the clinical outcome after adjustment for gender, aetiology and New York Heart Association class: hazard ratio (HR) 0.791 [95% confidence interval (CI) 0.658\u20130.950, P= 0.012] and HR 0.846 (95% CI 0.723\u20130.991, P= 0.038), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Left ventricular dP\/dtmax measured at baseline and during CRT are predictors of 1-year survival free from all-cause mortality, HTX, or LVAD implantation, but the acute improvement in dP\/dtmax is not correlated to clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfr094","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T20:56:08Z","timestamp":1311713768000},"page":"1126-1132","source":"Crossref","is-referenced-by-count":79,"title":["Baseline Left Ventricular d\n                    <i>P<\/i>\n                    \/d\n                    <i>t<\/i>\n                    max Rather than the Acute Improvement in d\n                    <i>P<\/i>\n                    \/d\n                    <i>t<\/i>\n                    max Predicts Clinical Outcome in Patients with Cardiac Resynchronization Therapy"],"prefix":"10.1093","volume":"13","author":[{"given":"Margot D.","family":"Bogaard","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Houthuizen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]},{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Bracke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.","family":"Doevendans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits W.","family":"Prinzen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Meine","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berry M.","family":"van Gelder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026020203285248200_ejhfhfr094-bib-0001","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"2026020203285248200_ejhfhfr094-bib-0002","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The effect of cardiac resynchronization on morbidity and mortality in heart 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