{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:30:05Z","timestamp":1768930205195,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Survival preferences, ascertained from time-trade-off utilities, have not been studied in heart failure patients who designate a \u2018do not resuscitate\u2019 (DNR) status. Therefore, the aim of this study was to determine the association of heart failure patients' resuscitation preferences with survival preferences and mortality in the ESCAPE trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed the association of resuscitation orders at 1 month with time-trade-off utilities and 6-month mortality. There were 26 and 349 patients with a DNR order and Full Code order, respectively. DNR patients were older, had more coronary artery disease, hypertension, renal impairment, and poorer exercise capacity than Full Code patients. DNR patients also experienced longer hospitalization and higher 6-month mortality. In multivariate analysis, DNR preference was associated with 10-fold higher odds of willingness to trade survival time (lower time-trade-off utility) in favour of improved quality of life [odds ratio 10.33, 95% confidence interval (CI) 1.65\u201364.80]. DNR preference was the best predictor of mortality (\u03c72 26.12, P &amp;lt; 0.0001, hazard ratio 6.88, 95% CI 3.28\u201314.41), despite adjustment for known predictors including brain natriuretic peptide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Heart failure patients' requests to forgo resuscitation may signify more than simply \u2018what-if\u2019 directives for emergency care. DNR decisions may reflect preferences for intervention to enhance quality rather than prolong survival, which is particularly important as these patients have high early mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfr142","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T20:49:25Z","timestamp":1319834965000},"page":"45-53","source":"Crossref","is-referenced-by-count":27,"title":["Link Between Decisions Regarding Resuscitation and Preferences for Quality Over Length of Life with Heart Failure"],"prefix":"10.1093","volume":"14","author":[{"given":"Sandesh","family":"Dev","sequence":"first","affiliation":[{"name":"Phoenix VA Health Care System , 650 E. Indian School Rd, Routing 111F, Phoenix, AZ, 85012 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Clare","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Michael","family":"Felker","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Fiuzat","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne Warner","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026011921191012700_ejhfhfr142-bib-0001","volume-title":"Crossing the Quality Chasm: A New Health System for the 21st Century","author":"Committee on Quality of Health Care in America IoM","year":"2001"},{"key":"2026011921191012700_ejhfhfr142-bib-0002","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cardfail.2005.11.005","article-title":"HFSA 2006 Comprehensive Heart Failure Practice Guideline","volume":"12","author":"Adams","year":"2006","journal-title":"J Card Fail"},{"key":"2026011921191012700_ejhfhfr142-bib-0003","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1007\/s11606-008-0748-0","article-title":"Using the experiences of bereaved caregivers to inform patient- and caregiver-centered advance care planning","volume":"23","author":"Fried","year":"2008","journal-title":"J Gen Intern Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0004","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1056\/NEJMsa012528","article-title":"Understanding the treatment preferences of seriously ill patients","volume":"346","author":"Fried","year":"2002","journal-title":"N Engl J Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0005","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.jacc.2008.08.028","article-title":"Changing preferences for survival after hospitalization with advanced heart failure","volume":"52","author":"Stevenson","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026011921191012700_ejhfhfr142-bib-0006","doi-asserted-by":"crossref","first-page":"621","DOI":"10.7326\/0003-4819-128-8-199804150-00002","article-title":"The accuracy of substituted judgments in patients with terminal diagnoses","volume":"128","author":"Sulmasy","year":"1998","journal-title":"Ann Intern Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0007","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0002-9343(97)89450-8","article-title":"Choices of seriously ill patients about cardiopulmonary resuscitation: correlates and outcomes","volume":"100","author":"Phillips","year":"1996","journal-title":"Am J Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0008","first-page":"23","article-title":"Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and management","volume":"22","author":"Arnold","year":"2006","journal-title":"Can J Cardiol"},{"key":"2026011921191012700_ejhfhfr142-bib-0009","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1378\/chest.117.5.1474","article-title":"End-of-life care preferences of patients enrolled in cardiovascular rehabilitation programs","volume":"117","author":"Heffner","year":"2000","journal-title":"Chest"},{"key":"2026011921191012700_ejhfhfr142-bib-0010","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/01.CIR.98.7.648","article-title":"Resuscitation preferences among patients with severe congestive heart failure: results from the SUPPORT project","volume":"98","author":"Krumholz","year":"1998","journal-title":"Circulation"},{"key":"2026011921191012700_ejhfhfr142-bib-0011","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ahj.2008.01.030","article-title":"Impact of do-not-resuscitation orders on quality of care performance measures in patients hospitalized with acute heart failure","volume":"156","author":"Chen","year":"2008","journal-title":"Am Heart J"},{"key":"2026011921191012700_ejhfhfr142-bib-0012","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/jama.279.5.371","article-title":"Health values of hospitalized patients 80 years or older","volume":"279","author":"Tsevat","year":"1998","journal-title":"JAMA"},{"key":"2026011921191012700_ejhfhfr142-bib-0013","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1001\/jama.294.13.1625","article-title":"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial","volume":"294","author":"The EIaESC","year":"2005","journal-title":"JAMA"},{"key":"2026011921191012700_ejhfhfr142-bib-0014","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/CCM.0b013e3181feb8f6","article-title":"Partial do-not-resuscitate orders: a hazard to patient safety and clinical outcomes?","volume":"39","author":"Sanders","year":"2011","journal-title":"Crit Care Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0015","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jacc.2009.08.083","article-title":"Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score","volume":"55","author":"O'Connor","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2026011921191012700_ejhfhfr142-bib-0016","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1067\/mhj.2001.113995","article-title":"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness (ESCAPE): design and rationale","volume":"141","author":"Shah","year":"2001","journal-title":"Am Heart J"},{"key":"2026011921191012700_ejhfhfr142-bib-0017","doi-asserted-by":"crossref","first-page":"514","DOI":"10.7326\/0003-4819-122-7-199504010-00007","article-title":"Health values of the seriously ill","volume":"122","author":"Tsevat","year":"1995","journal-title":"Ann Intern Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0018","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1071-9164(99)90030-1","article-title":"Patient preferences for heart failure treatment: utilities are valid measures of health-related quality of life in heart failure","volume":"5","author":"Havranek","year":"1999","journal-title":"J Card Fail"},{"key":"2026011921191012700_ejhfhfr142-bib-0019","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cardfail.2003.11.002","article-title":"The relationship between health perception and utility in heart failure patients in a clinical trial: results from an OVERTURE substudy","volume":"10","author":"Havranek","year":"2004","journal-title":"J Card Fail"},{"key":"2026011921191012700_ejhfhfr142-bib-0020","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1001\/archinte.1995.00430190042006","article-title":"Epidemiology of do-not-resuscitate orders. Disparity by age, diagnosis, gender, race, and functional impairment","volume":"155","author":"Wenger","year":"1995","journal-title":"Arch Intern Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0021","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s11606-009-0952-6","article-title":"Racial and ethnic differences in preferences for end-of-life treatment","volume":"24","author":"Barnato","year":"2009","journal-title":"J Gen Intern Med"},{"key":"2026011921191012700_ejhfhfr142-bib-0022","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1067\/mhj.2001.117606","article-title":"Inotropic therapy for heart failure: an evidence-based approach","volume":"142","author":"Felker","year":"2001","journal-title":"Am Heart J"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfr142","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfr142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1093\/eurjhf\/hfr142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1093\/eurjhf\/hfr142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/14\/1\/45\/66443223\/eurjhf_14_1_45.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/14\/1\/45\/66443223\/eurjhf_14_1_45.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:25:32Z","timestamp":1768875932000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/14\/1\/45\/8429041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,1]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,2,18]]},"published-print":{"date-parts":[[2012,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfr142","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,1]]},"published":{"date-parts":[[2012,1,1]]}}}