{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:08:21Z","timestamp":1769044101049,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the predictive value of a baseline speckle tracking strain rate imaging-derived discoordination index for response to cardiac resynchronization therapy (CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Ninety-seven patients with QRS \u2265120 ms and left ventricular (LV) ejection fraction \u226435% were prospectively followed after CRT in the Mayo CRT Registry. The LV discoordination index (stretch\/shortening or thinning\/thickening during ejection) was calculated from three types of deformation, radial, circumferential, and longitudinal, using two-dimensional speckle tracking strain rate imaging. The benefit of CRT was evaluated by reverse remodelling (i.e. reduction of LV end-systolic volume \u226515% at 6-month follow-up) and survival. The optimal cut-off value of the baseline discoordination index in discriminating responders from non-responders was determined by receiver operating characteristic curve analysis. Significant differences in baseline indices between responders and non-responders were noted for radial and circumferential discoordination indices. A mid-ventricular radial discoordination index (RDI-M) &amp;gt;38% best predicted responders, especially in patients with ischaemic cardiomyopathy (area under the curve 0.86 for all patients, sensitivity 80%, and specificity 91%). Death occurred in 28 patients over a median follow-up of 3.2 years. When adjusted for confounding variables, lack of significant discoordination (RDI-M &amp;lt;38%) before CRT was associated with a particularly high mortality (hazard ratio 7.05, 95% confidence interval 2.45\u201326.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LV discoordination assessed by speckle tracking RDI-M imaging was able to predict reverse remodelling at 6 months and survival of patients who received CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfs025","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T21:45:39Z","timestamp":1331588739000},"page":"517-525","source":"Crossref","is-referenced-by-count":21,"title":["Left Ventricular Discoordination Index Measured by Speckle Tracking Strain Rate Imaging Predicts Reverse Remodelling and Survival After Cardiac Resynchronization Therapy"],"prefix":"10.1093","volume":"14","author":[{"given":"Chun-Li","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]},{"name":"First Division of Cardiovascular Department, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University , Taoyuan ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D.","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"Redfield","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinami","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Higashisumiyoshi Morimoto Hospital , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nowell M.","family":"Fine","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle J.","family":"Olson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Mei","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul E.","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David O.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae K.","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic , Rochester, MN, 55905 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026011921181743300_ejhfhfs025-bib-0001","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N Engl J Med"},{"key":"2026011921181743300_ejhfhfs025-bib-0002","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1056\/NEJM200103223441202","article-title":"Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay","volume":"344","author":"Cazeau","year":"2001","journal-title":"N Engl J Med"},{"key":"2026011921181743300_ejhfhfs025-bib-0003","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"2026011921181743300_ejhfhfs025-bib-0004","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/CIRCULATIONAHA.107.750190","article-title":"Longitudinal strain delay index by speckle tracking imaging: a new marker of response to cardiac resynchronization therapy","volume":"118","author":"Lim","year":"2008","journal-title":"Circulation"},{"key":"2026011921181743300_ejhfhfs025-bib-0005","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/eurheartj\/ehp050","article-title":"Low-dose dobutamine stress echo to quantify the degree of remodelling after cardiac resynchronization therapy","volume":"30","author":"Parsai","year":"2009","journal-title":"Eur Heart J"},{"key":"2026011921181743300_ejhfhfs025-bib-0006","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0735-1097(02)02337-9","article-title":"Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony","volume":"40","author":"Pitzalis","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026011921181743300_ejhfhfs025-bib-0007","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2004.08.016","article-title":"Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy","volume":"44","author":"Bax","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2026011921181743300_ejhfhfs025-bib-0008","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/01.CIR.0000133276.45198.A5","article-title":"Tissue Doppler imaging is superior to strain rate imaging and postsystolic shortening on the prediction of reverse remodeling in both ischaemic and nonischaemic heart failure after cardiac resynchronization therapy","volume":"110","author":"Yu","year":"2004","journal-title":"Circulation"},{"key":"2026011921181743300_ejhfhfs025-bib-0009","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/CIRCULATIONAHA.105.571455","article-title":"Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy","volume":"113","author":"Suffoletto","year":"2006","journal-title":"Circulation"},{"key":"2026011921181743300_ejhfhfs025-bib-0010","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/CIRCULATIONAHA.104.474445","article-title":"Real-time three-dimensional echocardiography: a novel technique to quantify global left ventricular mechanical dyssynchrony","volume":"112","author":"Kapetanakis","year":"2005","journal-title":"Circulation"},{"key":"2026011921181743300_ejhfhfs025-bib-0011","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/CIRCULATIONAHA.107.743120","article-title":"Results of the Predictors of Response to CRT (PROSPECT) trial","volume":"117","author":"Chung","year":"2008","journal-title":"Circulation"},{"key":"2026011921181743300_ejhfhfs025-bib-0012","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCHEARTFAILURE.108.848085","article-title":"Dyssynchrony indices to predict response to cardiac resynchronization therapy: a comprehensive prospective single-center study","volume":"3","author":"Miyazaki","year":"2010","journal-title":"Circ Heart Fail"},{"key":"2026011921181743300_ejhfhfs025-bib-0013","doi-asserted-by":"crossref","first-page":"H640","DOI":"10.1152\/ajpheart.00106.2008","article-title":"Mechanical discoordination rather than dyssynchrony predicts reverse remodeling upon cardiac resynchronization","volume":"295","author":"Kirn","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026011921181743300_ejhfhfs025-bib-0014","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.echo.2010.03.012","article-title":"Recoordination rather than resynchronization predicts reverse remodeling after cardiac resynchronization therapy","volume":"23","author":"Wang","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"2026011921181743300_ejhfhfs025-bib-0015","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/eurjhf\/hfp107","article-title":"Septal rebound stretch reflects the functional substrate to cardiac resynchronization therapy and predicts volumetric and neurohormonal response","volume":"11","author":"De Boeck","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026011921181743300_ejhfhfs025-bib-0016","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.jacc.2008.02.040","article-title":"Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy","volume":"51","author":"Delgado","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026011921181743300_ejhfhfs025-bib-0017","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10741-010-9200-8","article-title":"Echocardiographic prediction of outcome after cardiac resynchronization therapy: conventional methods and recent developments","volume":"16","author":"Leenders","year":"2011","journal-title":"Heart Fail Rev"},{"key":"2026011921181743300_ejhfhfs025-bib-0018","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/eurheartj\/ehn481","article-title":"Toward understanding response to cardiac resynchronization therapy: left ventricular dyssynchrony is only one of multiple mechanisms","volume":"30","author":"Parsai","year":"2009","journal-title":"Eur Heart J"},{"key":"2026011921181743300_ejhfhfs025-bib-0019","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/eurheartj\/ehp050","article-title":"Low-dose dobutamine stress echo to quantify the degree of remodeling after cardiac resynchronization therapy","volume":"30","author":"Parsai","year":"2009","journal-title":"Eur Heart J"},{"key":"2026011921181743300_ejhfhfs025-bib-0020","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/eurheartj\/ehn577","article-title":"The effects of aetiology on outcome in patients treated with cardiac resynchronization therapy in the CARE-HF trial","volume":"30","author":"Wikstrom","year":"2009","journal-title":"Eur Heart J"},{"key":"2026011921181743300_ejhfhfs025-bib-0021","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jacc.2008.04.036","article-title":"Predicting the long-term effects of cardiac resynchronization therapy on mortality from baseline variables and the early response: a report from the CARE-HF (Cardiac Resynchronization in Heart Failure) Trial","volume":"52","author":"Cleland","year":"2008","journal-title":"J Am Coll Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfs025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/14\/5\/517\/66442865\/eurjhf_14_5_517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/14\/5\/517\/66442865\/eurjhf_14_5_517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:24:11Z","timestamp":1768875851000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/14\/5\/517\/8428981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,1]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,2,18]]},"published-print":{"date-parts":[[2012,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfs025","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,5]]},"published":{"date-parts":[[2012,5,1]]}}}