{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:09:57Z","timestamp":1780092597947,"version":"3.54.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The outcome of patients with chronic heart failure (CHF) following an ischaemic event is poorly understood. We evaluated the management and outcomes of CHF patients presenting with an acute coronary syndrome (ACS) and explored changes in outcomes over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method and results<\/jats:title>\n                    <jats:p>A total of 5556 patients enrolled in the Australia\u2013New Zealand population of the Global Registry of Acute Coronary Events (GRACE) between 1999 and 2007 were included. Patients with CHF (n = 609) were compared with those without CHF (n = 4947). Patients with CHF were on average 10 years older, were more likely to be female, had more co-morbidities and cardiac risk factors, and were more likely to have a prior history of angina, myocardial infarction, and revascularization by coronary artery bypass graft (CABG) when compared with those without CHF. CHF was associated with a substantial increase in in-hospital renal failure [odds ratio (OR) 1.76, 95% confidence interval (CI) 1.15\u20132.71], readmission post-discharge (OR 1.47, 95% CI 1.17\u20131.90), and 6-month mortality (OR 2.25, 95% CI 1.55\u20133.27). Over the 9 year study period, in-hospital and 6 month mortality in those with CHF declined by absolute rates of 7.5% and 14%, respectively. This was temporally associated with an increase in prescription of thienopyridines, beta-blockers, statins, and angiotensin II receptor blockers, increased rates of coronary angiography, and 31.8% absolute increase in referral rates for cardiac rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute coronary syndrome patients with pre-existing CHF are a very high risk group and carry a disproportionate mortality burden. Encouragingly, there was a marked temporal improvement in outcomes over a 9 year period with an increase in evidence-based treatments and secondary preventative measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfs041","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T20:27:42Z","timestamp":1334262462000},"page":"464-472","source":"Crossref","is-referenced-by-count":16,"title":["Management and Outcomes Following an Acute Coronary Event in Patients with Chronic Heart Failure 1999\u20132007"],"prefix":"10.1093","volume":"14","author":[{"given":"Isuru","family":"Ranasinghe","sequence":"first","affiliation":[{"name":"Concord Repatriation General Hospital and The University of Sydney , Sydney, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Naoum","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital and The University of Sydney , Sydney, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Aliprandi-Costa","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital and The University of Sydney , Sydney, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Sindone","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital and The University of Sydney , Sydney, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"INSERM U-698, H\u00f4pital Bichat, and Universite Paris 7 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Elliott","sequence":"additional","affiliation":[{"name":"Christchurch Hospital , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"McGarity","sequence":"additional","affiliation":[{"name":"Bathurst Base Hospital , Bathurst, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lefkovits","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brieger","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital and The University of Sydney , Sydney, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026011921182242300_ejhfhfs041-bib-0001","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0735-1097(02)02173-3","article-title":"Hospital outcomes in patients presenting with congestive heart failure complicating acute myocardial infarction: a report from the Second National Registry of Myocardial Infarction (NRMI-2)","volume":"40","author":"Wu","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026011921182242300_ejhfhfs041-bib-0002","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.CIR.0000109691.16944.DA","article-title":"Determinants and prognostic impact of heart failure complicating acute coronary syndromes: observations from the Global Registry of Acute Coronary Events (GRACE)","volume":"109","author":"Steg","year":"2004","journal-title":"Circulation"},{"key":"2026011921182242300_ejhfhfs041-bib-0003","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1001\/archinternmed.2007.80","article-title":"Incidence and prevalence of heart failure in elderly persons, 1994\u20132003","volume":"168","author":"Curtis","year":"2008","journal-title":"Arch Intern Med"},{"key":"2026011921182242300_ejhfhfs041-bib-0004","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.ehj.2004.06.038","article-title":"Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure. The Rotterdam Study","volume":"25","author":"Bleumink","year":"2004","journal-title":"Eur Heart J"},{"key":"2026011921182242300_ejhfhfs041-bib-0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jacc.2008.08.067","article-title":"Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction","volume":"53","author":"Ezekowitz","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2026011921182242300_ejhfhfs041-bib-0006","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/01.CIR.0000017861.00991.2F","article-title":"Heterogeneity in the management and outcomes of patients with acute myocardial infarction complicated by heart failure: the National Registry of Myocardial Infarction","volume":"105","author":"Spencer","year":"2002","journal-title":"Circulation"},{"key":"2026011921182242300_ejhfhfs041-bib-0007","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/eurheartj\/ehn062","article-title":"Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and\/or left ventricular dysfunction: a VALIANT study","volume":"29","author":"Lewis","year":"2008","journal-title":"Eur Heart J"},{"key":"2026011921182242300_ejhfhfs041-bib-0008","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1067\/mhj.2001.112404","article-title":"Rationale and design of the GRACE (Global Registry of Acute Coronary Events) project: a multinational registry of patients hospitalized with acute coronary syndromes","volume":"141","author":"GRACE Investigators","year":"2001","journal-title":"Am Heart J"},{"key":"2026011921182242300_ejhfhfs041-bib-0009","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/eurheartj\/ehn503","article-title":"Impact of hospitalization for acute coronary events on subsequent mortality in patients with chronic heart failure","volume":"30","author":"Abrahamsson","year":"2009","journal-title":"Eur Heart J"},{"key":"2026011921182242300_ejhfhfs041-bib-0010","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/eurjhf\/hfr003","article-title":"Impact of concomitant heart failure on outcomes in patients undergoing percutaneous coronary interventions: analysis of the Melbourne Interventional Group registry","volume":"13","author":"Lu","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026011921182242300_ejhfhfs041-bib-0011","doi-asserted-by":"crossref","first-page":"722","DOI":"10.2471\/BLT.06.031286","article-title":"Is mortality from heart failure increasing in Australia? 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