{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:20:05Z","timestamp":1788369605918,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The impact of cardiac dysfunction on the liver is known as cardiac hepatopathy. In certain instances this can result in significant hepatic fibrosis or cirrhosis. The validity of non-invasive tools to assess hepatic fibrosis, such as FibroScan\u00ae which measures liver stiffness (LSM), has not been established in this setting. We examined the impact of cardiac dysfunction on LSM using FibroScan\u00ae and the influence of volume changes on LSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A prospective, cross-sectional study examined the use of FibroScan\u00ae in subjects with left-sided heart failure (LHF, n = 32), right-sided heart failure (RHF, n = 9), and acute decompensated heart failure (ADHF, n = 8). The impact of volume changes upon LSM was further examined in the ADHF group (pre- and post-diuresis) and in a haemodialysis group (HD, n = 12), pre- and post-ultrafiltration on dialysis. Compared with healthy controls [n = 55, LSM = median 4.4 (25th percentile 3.6, 75th percentile 5.1) kPa], LSM was increased in all the cardiac dysfunction subgroups [LHF, 4.7 (4.0, 8.7) kPa, P = 0.04; RHF, 9.7 (5.0, 10.8) kPa, P &amp;lt; 0.001; ADHF, 11.2 (6.7, 14.3) kPa, P &amp;lt; 0.001]. Alteration in volume status via diuresis did not change the baseline LSM in ADHF [11.2 (6.7, 14.3) to 9.5 (7.3, 21.6) kPa, P &amp;gt; 0.05] with mean diuresis 5051 \u00b1 1585 mL, or ultrafiltration in HD [6.0 (3.6, 5.1) vs. 5.7 (4.8, 7.0) kPa, P &amp;gt; 0.05] with mean diuresis 1962 \u00b1 233 mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support the concept of increased LSM in the cardiac failure population. LSM was not altered to a statistically significant level with acute volume changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfs044","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T02:04:35Z","timestamp":1334973875000},"page":"621-627","source":"Crossref","is-referenced-by-count":75,"title":["Impact of Heart Failure and Changes to Volume Status on Liver Stiffness: Non-Invasive Assessment Using Transient Elastography"],"prefix":"10.1093","volume":"14","author":[{"given":"Ingrid","family":"Hopper","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics"},{"name":"Department of Epidemiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornwalee","family":"Porapakkham","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intervention"},{"name":"Department of Epidemiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sata","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics"},{"name":"Department of Epidemiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eilis","family":"Condon","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Skiba","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics"},{"name":"Department of Epidemiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Farber","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramote","family":"Porapakkham","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Central Chest Institute of Thailand, Department of Medical Services, Ministry of Public Health \u00a0","place":["Thailand"]},{"name":"Department of Epidemiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of AIRmed"},{"name":"Department of Medicine, Monash Medical School, Monash University , Melbourne ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Menahem","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, The Alfred , Melbourne ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Krum","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics"},{"name":"Department of Epidemiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"2026011921180377100_ejhfhfs044-bib-0001","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1098\/rstl.1833.0031","article-title":"The anatomy and physiology of the liver","volume":"123","author":"Kiernan","year":"1833","journal-title":"Philos Trans R Soc B: Biol Sci"},{"key":"2026011921180377100_ejhfhfs044-bib-0002","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/hrt.13.3.273","article-title":"The liver in heart failure: relation of anatomical, functional, and circulatory changes","volume":"13","author":"Sherlock","year":"1951","journal-title":"Br Heart J"},{"key":"2026011921180377100_ejhfhfs044-bib-0003","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1172\/JCI102008","article-title":"An estimation of hepatic blood flow and splanchnic oxygen consumption in heart failure","volume":"27","author":"Myers","year":"1948","journal-title":"J Clin Invest"},{"key":"2026011921180377100_ejhfhfs044-bib-0004","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0002-9343(61)90093-6","article-title":"Alterations in indices of liver funtion in congestive heart failure with particular reference to serum enzymes","volume":"30","author":"Richman","year":"1961","journal-title":"Am J Med"},{"key":"2026011921180377100_ejhfhfs044-bib-0005","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1001\/archinte.1987.00370070041006","article-title":"Liver function abnormalities in chronic heart failure. 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