{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:05:11Z","timestamp":1790316311490,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine whether severity patterns or nocturnal ventilation to treat sleep-disordered breathing (SDB) during chronic heart failure (CHF) is associated with adverse outcomes. Although SDB is frequent during CHF, the relationships between SDB and CHF outcomes are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of 384 CHF patients (82% men, mean age 59 \u00b1 13 years) with a left ventricular ejection fraction (LVEF) of \u226445% (mean LVEF 29 \u00b1 9%) were assessed by polygraphy in our clinic between 2001 and 2009. Nocturnal ventilation was started according to the severity of SDB. Combined endpoints were death, heart transplant, and implant of a ventricular assist device. The prevalence of obstructive sleep apnoea (OSA), central sleep apnoea (CSA), and Cheyne\u2013Stokes respiration (CSR) was 62, 26, and 29%, respectively. A primary endpoint occurred in 31%. Mean follow-up for survivors was 47 \u00b1 25 months. Those with moderate [apnoea\u2013hypopnoea index (AHI) \u22645\u201320\/h] and severe SDB (AHI \u226520\/h), and OSA and CSA, had poor prognoses compared with patients without SDB (P = 0.036, P = 0.003, respectively). A total of 31% of SDB patients were treated with nocturnal ventilation. Treated SDB had a better outcome than untreated severe SDB after adjustment for confounding factors [P = 0.031; hazard ratio (HR) 0.56; 95% confidence interval (CI) 0.33\u20130.95]. Subgroup analysis that included only OSA showed a similar result after adjustment (P = 0.017; HR 0.40; 95% CI 0.19\u20130.95).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CHF, SDB is associated with a poor prognosis whatever the SDB pattern, and nocturnal ventilation is associated with a better outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfs085","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T23:50:37Z","timestamp":1340409037000},"page":"1009-1019","source":"Crossref","is-referenced-by-count":121,"title":["Prognostic Impact of Sleep-Disordered Breathing and its Treatment with Nocturnal Ventilation for Chronic Heart Failure"],"prefix":"10.1093","volume":"14","author":[{"given":"Thibaud","family":"Damy","sequence":"first","affiliation":[{"name":"Federation de Cardiologie, AP-HP, Groupe Henri-Mondor 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