{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:27:21Z","timestamp":1768930041789,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Abnormal bone metabolism and progressive demineralization have been described in patients with heart failure (HF). We hypothesized that mechanical unloading through implantation of a ventricular assist device (VAD) with subsequent haemodynamic improvement would correct abnormal bone metabolism in patients with advanced HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Serum was collected from 14 controls, 20 patients with moderate HF, 34 patients with advanced HF undergoing VAD implantation, and 34 patients at the time of VAD explantation (mean duration: 169 \u00b1 125 days). Bone metabolism markers were measured using enzyme-linked immunosorption assay (ELISA) or chemiluminescence immunoassay (CLIA). Compared with controls, HF patients showed increased parathyroid hormone (PTH: 42 \u00b1 19 vs. 117 \u00b1 117 pg\/mL in HF; P &amp;lt; 0.02) with decreased 25-hydroxyvitamin D [25(OH)D: 29 \u00b1 14 vs. 21 \u00b1 11 ng\/mL in HF; P = 0.05]. While procollagen-1 N-terminal peptide (P1NP) and osteocalcin were similar, cross-linked C- and N-telopeptides of type I collagen (CTX and NTX) were both higher in HF (NTX: 14 \u00b1 6 vs. 20 \u00b1 11 ng\/mL; P &amp;lt; 0.05; CTX: 0.35 \u00b1 0.13 vs. 1.05 \u00b1 0.78 ng\/mL; P &amp;lt; 0.01 for controls and HF, respectively). P1NP increased markedly after VAD implantation (49 \u00b1 37 vs. 121 \u00b1 62 ng\/mL; P &amp;lt; 0.0001), with a mild decrease in CTX and NTX levels indicating a shift towards anabolic bone formation. Serum PTH correlated with estimated glomerular filtration rate (r = \u20130.245, P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with advanced HF are characterized by increased levels of biochemical markers of bone resorption potentially as a result of secondary hyperparathyroidism and uncoupling of bone remodelling. Haemodynamic improvement and mechanical unloading after VAD implantation lead to correction of bone metabolism and increased levels of anabolic bone formation markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfs138","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T02:47:55Z","timestamp":1348022875000},"page":"1356-1365","source":"Crossref","is-referenced-by-count":24,"title":["Dynamics of Bone Turnover Markers in Patients with Heart Failure and Following Haemodynamic Improvement Through Ventricular Assist Device Implantation"],"prefix":"10.1093","volume":"14","author":[{"given":"Christina","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiology, Columbia University Medical Center , New York, NY, 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko S.","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, Columbia University Medical Center , New York, NY, 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Pronschinske","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, Columbia University Medical Center , New York, NY, 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, Columbia University Medical Center , New York, NY, 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Medical Center , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Medical Center , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Schulze-Sp\u00e4te","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Section of Oral and Diagnostic Sciences, Columbia University College of Dental Medicine , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Cremers","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Columbia University Medical Center , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Columbia University Medical Center , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, Columbia University Medical Center , New York, NY, 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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