{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:25:45Z","timestamp":1768929945626,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Data on the prognosis of heart failure (HF) patients with coronary artery disease (CAD) have been conflicting. We describe the clinical characteristics and mode-specific outcomes of HF patients with reduced ejection fraction (EF) and documented CAD in a large randomized trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>EVEREST was a prospective, randomized trial of vasopressin-2 receptor blockade, in addition to standard therapy, in 4133 patients hospitalized with worsening HF and reduced EF. Patients were classified as having CAD based on patient-reported myocardial infarction (MI) or coronary revascularization. We analysed the characteristics and outcomes [all-cause mortality and cardiovascular (CV) mortality\/HF hospitalization] of patients with and without documented CAD. All events were centrally adjudicated. Documented CAD was present in 2353 patients (57%). Patients with CAD were older and had more co-morbidities compared with those without CAD. Patients with CAD were more likely to receive a beta-blocker, but less likely to receive an angiotensin-converting enzyme (ACE) inhibitor or aldosterone antagonist (P &amp;lt; 0.01). After risk adjustment, patients with documented CAD had similar mortality [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.97\u20131.30], but were at an increased risk for CV mortality\/HF hospitalization (HR 1.25, 95% CI 1.12\u20131.41) due to an increased risk for HF hospitalization (HR 1.26, 95% CI 1.10\u20131.44). Patients with CAD had increased HF- and MI-related events, but similar rates of sudden cardiac death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Documented CAD in patients hospitalized for worsening HF with reduced EF was associated with a higher burden of co-morbidities, lower use of HF therapies (except beta-blockers), and increased HF hospitalization, while all-cause mortality was similar.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hfs139","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T01:21:38Z","timestamp":1347412898000},"page":"61-68","source":"Crossref","is-referenced-by-count":25,"title":["Influence of Documented History of Coronary Artery Disease on Outcomes in Patients Admitted for Worsening Heart Failure with Reduced Ejection Fraction in the EVEREST Trial"],"prefix":"10.1093","volume":"15","author":[{"given":"Robert J.","family":"Mentz","sequence":"first","affiliation":[{"name":"Duke University Medical Center , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley D.","family":"Allen","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J.","family":"Kwasny","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin A.","family":"Konstam","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center, Tufts Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Udelson","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center, Tufts Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Ambrosy","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela J.","family":"Fought","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthiah","family":"Vaduganathan","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital , Boston, MA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"Nancy University , Nancy ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo P.","family":"Maggioni","sequence":"additional","affiliation":[{"name":"Associazione Nazionale Medici Cardiologi Ospedalieri Research Center , Florence ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Swedberg","sequence":"additional","affiliation":[{"name":"Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert O.","family":"Bonow","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Gheorghiade","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"2026011921134668300_ejhfhfs139-bib-0001","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/01.CIR.97.3.282","article-title":"Chronic heart failure in the United States: a manifestation of coronary artery disease","volume":"97","author":"Gheorghiade","year":"1998","journal-title":"Circulation"},{"key":"2026011921134668300_ejhfhfs139-bib-0002","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/euhj.2000.2289","article-title":"Coronary artery disease as the cause of incident heart failure in the population","volume":"22","author":"Fox","year":"2001","journal-title":"Eur Heart J"},{"key":"2026011921134668300_ejhfhfs139-bib-0003","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/CIRCULATIONAHA.106.623199","article-title":"Navigating the crossroads of coronary artery disease and heart failure","volume":"114","author":"Gheorghiade","year":"2006","journal-title":"Circulation"},{"key":"2026011921134668300_ejhfhfs139-bib-0004","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0735-1097(97)00235-0","article-title":"Clinical determinants of mortality in patients with angiographically diagnosed ischemic or nonischemic cardiomyopathy","volume":"30","author":"Bart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0005","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/hrt.2005.066464","article-title":"Coronary artery disease and outcome in acute congestive heart failure","volume":"92","author":"Purek","year":"2006","journal-title":"Heart"},{"key":"2026011921134668300_ejhfhfs139-bib-0006","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0735-1097(01)01738-7","article-title":"A standardized definition of ischemic cardiomyopathy for use in clinical research","volume":"39","author":"Felker","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0007","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1056\/NEJM200004133421502","article-title":"Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy","volume":"342","author":"Felker","year":"2000","journal-title":"N Engl J Med"},{"key":"2026011921134668300_ejhfhfs139-bib-0008","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/eurjhf\/hfr030","article-title":"Predictors of clinical outcomes in elderly patients with heart failure","volume":"13","author":"Manzano","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026011921134668300_ejhfhfs139-bib-0009","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijcard.2010.04.092","article-title":"Coronary artery disease, coronary revascularization, and outcomes in chronic advanced systolic heart failure","volume":"151","author":"Gheorghiade","year":"2011","journal-title":"Int J Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0010","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.ejheart.2008.09.009","article-title":"Influence of coronary artery disease and coronary revascularization status on outcomes in patients with acute heart failure syndromes: a report from OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure)","volume":"10","author":"Rossi","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"2026011921134668300_ejhfhfs139-bib-0011","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cardfail.2005.03.009","article-title":"Rationale and design of the multicenter, randomized, double-blind, placebo-controlled study to evaluate the Efficacy of Vasopressin antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST)","volume":"11","author":"Gheorghiade","year":"2005","journal-title":"J Card Fail"},{"key":"2026011921134668300_ejhfhfs139-bib-0012","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/jama.297.12.1319","article-title":"Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial","volume":"297","author":"Konstam","year":"2007","journal-title":"JAMA"},{"key":"2026011921134668300_ejhfhfs139-bib-0013","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.ahj.2010.02.023","article-title":"Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program","volume":"159","author":"O\u2019Connor","year":"2010","journal-title":"Am Heart J"},{"key":"2026011921134668300_ejhfhfs139-bib-0014","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cardfail.2012.04.010","article-title":"The impact of chronic obstructive pulmonary disease in patients hospitalized for worsening heart failure with reduced ejection fraction: an Analysis of the EVEREST trial","volume":"18","author":"Mentz","year":"2012","journal-title":"J Card Fail"},{"key":"2026011921134668300_ejhfhfs139-bib-0015","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/S0735-1097(96)00380-4","article-title":"Relation between gender, etiology and survival in patients with symptomatic heart failure","volume":"28","author":"Adams","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0016","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0002-9149(87)91183-0","article-title":"Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy","volume":"59","author":"Likoff","year":"1987","journal-title":"Am J Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0017","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","volume":"353","author":"Effect of metoprolol CR\/XL in chronic heart failure: Metoprolol CR\/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)","year":"1999","journal-title":"Lancet"},{"key":"2026011921134668300_ejhfhfs139-bib-0018","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(98)11181-9","volume":"353","author":"The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial","year":"1999","journal-title":"Lancet"},{"key":"2026011921134668300_ejhfhfs139-bib-0019","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jacc.2004.07.062","article-title":"Aspirin use in older patients with heart failure and coronary artery disease: national prescription patterns and relationship with outcomes","volume":"46","author":"Masoudi","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0020","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(08)61240-4","article-title":"Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial","volume":"372","author":"Tavazzi","year":"2008","journal-title":"Lancet"},{"key":"2026011921134668300_ejhfhfs139-bib-0021","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1056\/NEJMoa0706201","article-title":"Rosuvastatin in older patients with systolic heart failure","volume":"357","author":"Kjekshus","year":"2007","journal-title":"N Engl J Med"},{"key":"2026011921134668300_ejhfhfs139-bib-0022","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/eurjhf\/hfq230","article-title":"The Heart Failure Revascularisation Trial (HEART)","volume":"13","author":"Cleland","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026011921134668300_ejhfhfs139-bib-0023","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/CIRCULATIONAHA.106.655076","article-title":"Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure","volume":"116","author":"Latini","year":"2007","journal-title":"Circulation"},{"key":"2026011921134668300_ejhfhfs139-bib-0024","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ahj.2003.10.014","article-title":"Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis","volume":"147","author":"Hudson","year":"2004","journal-title":"Am Heart J"},{"key":"2026011921134668300_ejhfhfs139-bib-0025","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1161\/01.CIR.0000145158.33801.F3","article-title":"Ongoing myocardial injury in stable severe heart failure: value of cardiac troponin T monitoring for high-risk patient identification","volume":"110","author":"Perna","year":"2004","journal-title":"Circulation"},{"key":"2026011921134668300_ejhfhfs139-bib-0026","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijcard.2004.01.017","article-title":"Minor myocardial damage detected by troponin T is a powerful predictor of long-term prognosis in patients with acute decompensated heart failure","volume":"99","author":"Perna","year":"2005","journal-title":"Int J Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0027","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/CIRCULATIONAHA.111.044149","article-title":"Serial measurement of cardiac troponin T using a highly sensitive assay in patients with chronic heart failure: data from 2 large randomized clinical trials","volume":"125","author":"Masson","year":"2012","journal-title":"Circulation"},{"key":"2026011921134668300_ejhfhfs139-bib-0028","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ahj.2007.01.041","article-title":"Repeated hospitalizations predict mortality in the community population with heart failure","volume":"154","author":"Setoguchi","year":"2007","journal-title":"Am Heart J"},{"key":"2026011921134668300_ejhfhfs139-bib-0029","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1161\/CIRCULATIONAHA.107.696906","article-title":"Influence of nonfatal hospitalization for heart failure on subsequent mortality in patients with chronic heart failure","volume":"116","author":"Solomon","year":"2007","journal-title":"Circulation"},{"key":"2026011921134668300_ejhfhfs139-bib-0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cardfail.2007.12.001","article-title":"Incident heart failure hospitalization and subsequent mortality in chronic heart failure: a propensity-matched study","volume":"14","author":"Ahmed","year":"2008","journal-title":"J Card Fail"},{"key":"2026011921134668300_ejhfhfs139-bib-0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjmed.2011.06.014","article-title":"The impact of prior heart failure hospitalizations on long-term mortality differs by baseline risk of death","volume":"125","author":"Kommuri","year":"2012","journal-title":"Am J Med"},{"key":"2026011921134668300_ejhfhfs139-bib-0032","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jacc.2008.03.061","article-title":"Heart failure-related hospitalization in the U.S., 1979 to 2004","volume":"52","author":"Fang","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0033","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1056\/NEJMoa1100356","article-title":"Coronary-artery bypass surgery in patients with left ventricular dysfunction","volume":"364","author":"Velazquez","year":"2011","journal-title":"N Engl J Med"},{"key":"2026011921134668300_ejhfhfs139-bib-0034","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jacc.2009.11.057","article-title":"Increased mortality associated with low use of clopidogrel in patients with heart failure and acute myocardial infarction not undergoing percutaneous coronary intervention: a nationwide study","volume":"55","author":"Bonde","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2026011921134668300_ejhfhfs139-bib-0035","article-title":"Aspirin, clopidogrel, and warfarin use and outcomes in a cohort of 580 patients discharged after hospitalization for decompensated heart failure","author":"Kozdag","year":"2011","journal-title":"Heart Vessels"},{"key":"2026011921134668300_ejhfhfs139-bib-0036","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/01.CIR.102.6.611","article-title":"Acute coronary findings at autopsy in heart failure patients with sudden death: results from the assessment of treatment with lisinopril and survival (ATLAS) trial","volume":"102","author":"Uretsky","year":"2000","journal-title":"Circulation"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfs139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Feurjhf%2Fhfs139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1093\/eurjhf\/hfs139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1093\/eurjhf\/hfs139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/15\/1\/61\/66443325\/eurjhf_15_1_61.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/15\/1\/61\/66443325\/eurjhf_15_1_61.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:15:51Z","timestamp":1768875351000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/15\/1\/61\/8428609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,27]]},"published-print":{"date-parts":[[2013,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjhf\/hfs139","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,1]]},"published":{"date-parts":[[2013,1,1]]}}}