{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:42:00Z","timestamp":1770435720028,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study investigated whether abnormal cardiac sympathetic nerve activity (SNA) is associated with the severity of central sleep apnoea (CSA) and whether adaptive servo-ventilation (ASV) therapy can improve cardiac SNA in heart failure (HF) patients with predominant CSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Overnight polysomnography was conducted to diagnose CSA. Cardiac SNA was analysed by [123I]metaiodobenzylguanidine scintigraphy in 26 consecutive HF patients with predominant CSA. Of the 26 patients, 10 agreed to ASV therapy. Cardiac SNA was analysed 6 months after initiating ASV based on a non-randomized protocol. The apnoea\u2013hypopnoea index and central apnoea index were significantly correlated with the washout rate (WR) and a delayed heart to mediastinal (H\/M) ratio, suggesting that SNA is associated with abnormal breathing patterns. The WR, H\/M ratio, plasma BNP level, and LVEF were significantly improved (WR, 40.0 \u00b1 11.6% vs. 34.6 \u00b1 11.4%, P = 0.046; H\/M ratio, 1.5 \u00b1 0.1 vs.1.8 \u00b1 0.3, P = 0.013; ln BNP, 5.4 \u00b1 1.0 vs. 4.6 \u00b1 1.2, P = 0.007; and LVEF, 43.8 \u00b1 10.4% vs. 47.0 \u00b1 10.6%, P &amp;lt; 0.001) in the ASV group patients, but not in the non-ASV group patients. Multiple linear regression analyses showed that a decreased WR was strongly associated with an increased LVEF (coefficient = \u20130.454, P = 0.013).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Abnormal cardiac SNA could be significantly correlated with the severity of CSA in HF patients. ASV therapy might improve cardiac function in these patients by partially mediating cardiac SNA regulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjhf\/hft049","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T03:41:35Z","timestamp":1363405295000},"page":"902-909","source":"Crossref","is-referenced-by-count":46,"title":["Adaptive Servo-Ventilation Therapy Improves Cardiac Sympathetic Nerve Activity in Patients with Heart Failure"],"prefix":"10.1093","volume":"15","author":[{"given":"Takashi","family":"Koyama","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondoh1-1-1 , Akita, 010-8543 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondoh1-1-1 , Akita, 010-8543 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondoh1-1-1 , Akita, 010-8543 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Oguma","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondoh1-1-1 , Akita, 010-8543 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondoh1-1-1 , Akita, 010-8543 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Hondoh1-1-1 , Akita, 010-8543 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"2026011921153691700_ejhfhft049-bib-0001","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/eurheartj\/ehm554","article-title":"Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study","volume":"29","author":"Tribouilloy","year":"2008","journal-title":"Eur Heart J"},{"key":"2026011921153691700_ejhfhft049-bib-0002","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1388-9842(00)00139-2","article-title":"Different baseline sympathovagal balance and cardiac autonomic responsiveness in ischemic and non-ischemic congestive heart failure","volume":"3","author":"Malfatto","year":"2001","journal-title":"Eur J Heart Fail"},{"key":"2026011921153691700_ejhfhft049-bib-0003","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1253\/circj.CJ-10-0082","article-title":"Beneficial effects of adaptive servo ventilation in patients with chronic heart failure","volume":"74","author":"Koyama","year":"2010","journal-title":"Circ J"},{"key":"2026011921153691700_ejhfhft049-bib-0004","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejheart.2006.08.003","article-title":"Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients","volume":"9","author":"Oldenburg","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2026011921153691700_ejhfhft049-bib-0005","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/eurjhf\/hfs085","article-title":"Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure","volume":"14","author":"Damy","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2026011921153691700_ejhfhft049-bib-0006","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/eurheartj\/ehq327","article-title":"Cheyne\u2013Stokes respiration and obstructive sleep apnoea are independent risk factors for malignant ventricular arrhythmias requiring appropriate cardioverter-defibrillator therapies in patients with congestive heart failure","volume":"32","author":"Bitter","year":"2011","journal-title":"Eur Heart J"},{"key":"2026011921153691700_ejhfhft049-bib-0007","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1253\/circj.CJ-12-0689","article-title":"Cheyne\u2013Stokes respiration in chronic heart failure. 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