{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:36:51Z","timestamp":1793299011794,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005036","name":"University of Bergen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hypertension has been suggested as a stronger risk factor for acute coronary syndromes (ACS) in women than men. Whether this also applies to stage 1 hypertension [blood pressure (BP) 130\u2013139\/80\u201389\u2009mmHg] is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We tested associations of stage 1 hypertension with ACS in 12\u00a0329 participants in the Hordaland Health Study (mean baseline age 41\u2009years, 52% women). Participants were grouped by baseline BP category: Normotension (BP\u2009&amp;lt;\u2009130\/80\u2009mmHg), stage 1 and stage 2 hypertension (BP \u2265140\/90\u2009mmHg). ACS was defined as hospitalization or death due to myocardial infarction or unstable angina pectoris during 16\u2009years of follow-up. At baseline, a lower proportion of women than men had stage 1 and 2 hypertension, respectively (25 vs. 35% and 14 vs. 31%, P\u2009&amp;lt;\u20090.001). During follow-up, 1.4% of women and 5.7% of men experienced incident ACS (P\u2009&amp;lt;\u20090.001). Adjusted for diabetes, smoking, body mass index, cholesterol, and physical activity, stage 1 hypertension was associated with higher risk of ACS in women [hazard ratio (HR) 2.18, 95% confidence interval (CI) 1.32\u20133.60], while the association was non-significant in men (HR 1.30, 95% CI 0.98\u20131.71). After additional adjustment for systolic and diastolic BP, respectively, stage 1 diastolic hypertension was associated with ACS in women (HR 2.79 [95% CI 1.62-4.82]), but not in men (HR 1.24 [95% CI 0.95-1.62]), while stage 1 systolic hypertension was not associated with ACS in either sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among subjects in their early 40s, stage 1 hypertension was a stronger risk factor for ACS during midlife in women than in men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwab068","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T23:06:33Z","timestamp":1618182393000},"page":"147-154","source":"Crossref","is-referenced-by-count":68,"title":["Stage 1 hypertension, sex, and acute coronary syndromes during midlife: the Hordaland Health Study"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-741X","authenticated-orcid":false,"given":"Ester","family":"Kringeland","sequence":"first","affiliation":[{"name":"Department of Clinical Science, University of Bergen, PO Box 7804, 5020 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grethe S","family":"Tell","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen, PO Box 7804, 5020 Bergen, Norway"},{"name":"Division of Mental and Physical Health, Norwegian Institute of Public Health, PO Box 973 Sentrum, 5808 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Midtb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannicke","family":"Igland","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen, PO Box 7804, 5020 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa R","family":"Haugsgjerd","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen, PO Box 7804, 5020 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gerdts","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, PO Box 7804, 5020 Bergen, Norway"},{"name":"Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"2022021921391485100_zwab068-B1","year":"2017"},{"key":"2022021921391485100_zwab068-B2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/CIRCULATIONAHA.118.037137","article-title":"Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction","volume":"139","author":"Arora","year":"2019","journal-title":"Circulation"},{"key":"2022021921391485100_zwab068-B3","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1177\/2047487313495993","article-title":"Favourable trends in incidence of AMI in Norway during 2001-2009 do not include younger adults: a CVDNOR project","volume":"21","author":"Sulo","year":"2014","journal-title":"Eur J Prev 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