{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:15:20Z","timestamp":1789820120171,"version":"4.0.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/16\/72\/32270"],"award-info":[{"award-number":["FS\/16\/72\/32270"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Max\u2019s Foundation and Great Ormond Street Hospital Children\u2019s Charity"},{"name":"Medical Research Council Clinical"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Academic Research Partnership"},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University College London Hospitals"},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Department of Health\u2019s"},{"name":"National Institute for Health Research Biomedical Research Centres"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["#1154992"],"award-info":[{"award-number":["#1154992"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Career Development Fellowship","award":["#1162929"],"award-info":[{"award-number":["#1162929"]}]},{"DOI":"10.13039\/100016619","name":"Myokardia, Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sudden cardiac death (SCD) is the most common mode of death in childhood hypertrophic cardiomyopathy (HCM). The newly developed HCM Risk-Kids model provides clinicians with individualized estimates of risk. The aim of this study was to externally validate the model in a large independent, multi-centre patient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A retrospective, longitudinal cohort of 421 patients diagnosed with HCM aged 1\u201316\u2009years independent of the HCM Risk-Kids development and internal validation cohort was studied. Data on HCM Risk-Kids predictor variables (unexplained syncope, non-sustained ventricular tachycardia, maximal left ventricular wall thickness, left atrial diameter, and left ventricular outflow tract gradient) were collected from the time of baseline clinical evaluation. The performance of the HCM Risk-Kids model in predicting risk at 5\u2009years was assessed. Twenty-three patients (5.4%) met the SCD end-point within 5\u2009years, with an overall incidence rate of 2.03 per 100 patient-years [95% confidence interval (CI) 1.48\u20132.78]. Model validation showed a Harrell\u2019s C-index of 0.745 (95% CI 0.52\u20130.97) and Uno\u2019s C-index 0.714 (95% 0.58\u20130.85) with a calibration slope of 1.15 (95% 0.51\u20131.80). A 5-year predicted risk threshold of \u22656% identified 17 (73.9%) SCD events with a corresponding C-statistic of 0.702 (95% CI 0.60\u20130.81).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study reports the first external validation of the HCM Risk-Kids model in a large and geographically diverse patient population. A 5-year predicted risk of \u22656% identified over 70% of events, confirming that HCM Risk-Kids provides a method for individualized risk predictions and shared decision-making in children with HCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwab181","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T20:48:32Z","timestamp":1634676512000},"page":"678-686","source":"Crossref","is-referenced-by-count":62,"title":["External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-237X","authenticated-orcid":false,"given":"Gabrielle","family":"Norrish","sequence":"first","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK"},{"name":"Institute of Cardiovascular Sciences, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Statistical Science, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Field","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK"},{"name":"Institute of Cardiovascular Sciences, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cervi","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diala","family":"Khraiche","sequence":"additional","affiliation":[{"name":"Necker \u2013 Enfants Malades hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Charite \u2013 Universitatsmedizin Berlin, Berlin, Germany"},{"name":"Experimental and Clinical Research Centre (ECRC), a joint cooperation between the Charit\u00e9 Medical Faculty and the Max-Delbr\u00fcck-Centre for Molecular Medicine (MDC), Charite \u2013 Universitatsmedizin Berlin, Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-7763","authenticated-orcid":false,"given":"Tiina H","family":"Ojala","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, New Children\u2019s Hospital, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Heart Muscle Disease Registry Trieste, University of Trieste, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokuni","family":"Yamazawa","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine and Graduate school of Medicine, Hokkaido University Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Marrone","sequence":"additional","affiliation":[{"name":"Fondazione Toscana G Monasterio, Massa-Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Popoiu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Children\u2019s Hospital \u2018Louis Turcanu\u2019, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Centeno","sequence":"additional","affiliation":[{"name":"Rio Hortega University Hospital, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Schouvey","sequence":"additional","affiliation":[{"name":"Hospital Saint Joseph, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-9266","authenticated-orcid":false,"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharlene M","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Colan","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rossano","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel G","family":"Wittekind","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Heart Institute, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Saberi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Helms","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-7676","authenticated-orcid":false,"given":"Jodie","family":"Ingles","sequence":"additional","affiliation":[{"name":"Cardio Genomics Program at Centenary Institute, The University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Semsarian","sequence":"additional","affiliation":[{"name":"Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, The University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry M","family":"Elliott","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University College London, London, UK"},{"name":"St Bartholomew\u2019s Centre for Inherited Cardiovascular Diseases, St Bartholomew\u2019s Hospital, West Smithfield, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn Y","family":"Ho","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumana Z","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Statistical Science, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P","family":"Kaski","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK"},{"name":"Institute of Cardiovascular Sciences, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"2022033100273080600_zwab181-B1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCULATIONAHA.106.621185","article-title":"Epidemiology and cause-specific outcome of hypertrophic cardiomyopathy in children: findings from the Pediatric Cardiomyopathy Registry","volume":"115","author":"Colan","year":"2007","journal-title":"Circulation"},{"key":"2022033100273080600_zwab181-B2","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/eurheartj\/ehy798","article-title":"Clinical presentation and survival of childhood hypertrophic cardiomyopathy: a retrospective study in United Kingdom","volume":"40","author":"Norrish","year":"2019","journal-title":"Eur Heart J"},{"key":"2022033100273080600_zwab181-B3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/CIRCULATIONAHA.120.047235","article-title":"A validated model for sudden cardiac death risk prediction in pediatric hypertrophic cardiomyopathy","volume":"142","author":"Miron","year":"2020","journal-title":"Circulation"},{"key":"2022033100273080600_zwab181-B4","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1093\/europace\/euz118","article-title":"A validation study of the European Society of Cardiology guidelines for risk stratification of sudden cardiac death in childhood hypertrophic cardiomyopathy","volume":"21","author":"Norrish","year":"2019","journal-title":"Europace"},{"key":"2022033100273080600_zwab181-B5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/jamacardio.2019.2861","article-title":"Development of a novel risk prediction model for sudden cardiac death in childhood hypertrophic cardiomyopathy (HCM Risk-Kids)","volume":"4","author":"Norrish","year":"2019","journal-title":"JAMA Cardiol"},{"key":"2022033100273080600_zwab181-B6","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"2022033100273080600_zwab181-B7","first-page":"e533","article-title":"2020 AHA\/ACC Guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"142","author":"Ommen","year":"2020","journal-title":"Circulation"},{"key":"2022033100273080600_zwab181-B8","doi-asserted-by":"crossref","first-page":"e006979","DOI":"10.1161\/CIRCIMAGING.117.006979","article-title":"Relationship of echocardiographic Z scores adjusted for body surface area to age, sex, race, and ethnicity: the pediatric heart network normal echocardiogram database","volume":"10","author":"Lopez","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022033100273080600_zwab181-B9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/ejechocard\/jen110","article-title":"Derivation of a size-independent variable for scaling of cardiac dimensions in a normal paediatric population","volume":"10","author":"Neilan","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"2022033100273080600_zwab181-B10","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R","article-title":"Multiple imputation of missing blood pressure covariates in survival analysis","volume":"18","author":"van Buuren","year":"1999","journal-title":"Stat Med"},{"key":"2022033100273080600_zwab181-B11","volume-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","year":"2004"},{"key":"2022033100273080600_zwab181-B12","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/sim.4154","article-title":"On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data","volume":"30","author":"Uno","year":"2011","journal-title":"Stat Med"},{"key":"2022033100273080600_zwab181-B13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12874-017-0336-2","article-title":"Review and evaluation of performance measures for survival prediction models in external validation settings","volume":"17","author":"Rahman","year":"2017","journal-title":"BMC Med Res Methodol"},{"key":"2022033100273080600_zwab181-B14","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1001\/jama.1982.03320430047030","article-title":"Evaluating the yield of medical tests","volume":"247","author":"Harrell","year":"1982","journal-title":"JAMA"},{"key":"2022033100273080600_zwab181-B15","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-77244-8","volume-title":"Clinical Prediction Modes: A Practical Approach to Development, Validation, and Updating","author":"Steyerberg","year":"2009"},{"key":"2022033100273080600_zwab181-B16","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1016\/j.jcmg.2020.06.009","article-title":"LGE for risk stratification in primary prevention in children with HCM","volume":"13","author":"Petryka-Mazurkiewicz","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022033100273080600_zwab181-B17","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00246-015-1298-y","article-title":"Predictors of long-term outcome in children with hypertrophic cardiomyopathy","volume":"37","author":"Zi\u00f3\u0142kowska","year":"2016","journal-title":"Pediatr Cardiol"},{"key":"2022033100273080600_zwab181-B18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/hrt.2006.094730","article-title":"Outcomes after implantable cardioverter-defibrillator treatment in children with hypertrophic cardiomyopathy","volume":"93","author":"Kaski","year":"2007","journal-title":"Heart"},{"key":"2022033100273080600_zwab181-B19","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/eurheartj\/eht439","article-title":"A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD)","volume":"35","author":"O'Mahony","year":"2014","journal-title":"Eur Heart J"},{"key":"2022033100273080600_zwab181-B20","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/CIRCULATIONAHA.117.030437","article-title":"An international external validation study of the 2014 European Society of Cardiology guideline on sudden cardiac death prevention in hypertrophic cardiomyopathy (evidence from HCM)","volume":"137","author":"O\u2019Mahony","year":"2018","journal-title":"Circulation"},{"key":"2022033100273080600_zwab181-B21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jamacardio.2018.0789","article-title":"Long-term outcomes of pediatric-onset hypertrophic cardiomyopathy and age-specific risk factors for lethal arrhythmic events","volume":"3","author":"Maurizi","year":"2018","journal-title":"JAMA Cardiol"},{"key":"2022033100273080600_zwab181-B22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/CIRCULATIONAHA.117.028895","article-title":"Long-term outcomes of hypertrophic cardiomyopathy diagnosed during childhood: results from a national population-based study","volume":"138","author":"Alexander","year":"2018","journal-title":"Circulation"},{"key":"2022033100273080600_zwab181-B23","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/eurheartj\/ehn122","article-title":"Age- and gender-specific mortality rates in childhood hypertrophic cardiomyopathy","volume":"29","author":"Ostman-Smith","year":"2008","journal-title":"Eur Heart J"},{"key":"2022033100273080600_zwab181-B24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.65.1.7","article-title":"Hypertrophic cardiomyopathy in infants: clinical features and natural history","volume":"65","author":"Maron","year":"1982","journal-title":"Circulation"},{"key":"2022033100273080600_zwab181-B25","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the Sarcomeric Human Cardiomyopathy Registry (SHaRe)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation"},{"key":"2022033100273080600_zwab181-B26","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jcmg.2016.02.031","article-title":"Prognostic value of LGE-CMR in HCM: a meta-analysis","volume":"9","author":"Weng","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022033100273080600_zwab181-B27","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.amjcard.2019.07.023","article-title":"Prognostic role of late gadolinium enhancement in patients with hypertrophic cardiomyopathy and low-to-intermediate sudden cardiac death risk score","volume":"124","author":"Todiere","year":"2019","journal-title":"Am J Cardiol"},{"key":"2022033100273080600_zwab181-B28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12968-019-0561-4","article-title":"The amount of late gadolinium enhancement outperforms current guideline-recommended criteria in the identification of patients with hypertrophic cardiomyopathy at risk of sudden cardiac death","volume":"21","author":"Freitas","year":"2019","journal-title":"J Cardiovasc Magn Reson"},{"key":"2022033100273080600_zwab181-B29","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/CIRCULATIONAHA.117.032966","article-title":"Prevalence and progression of late gadolinium enhancement in children and adolescents with hypertrophic cardiomyopathy","volume":"138","author":"Axelsson Raja","year":"2018","journal-title":"Circulation"}],"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/29\/4\/678\/43163930\/zwab181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/29\/4\/678\/43163930\/zwab181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T20:29:42Z","timestamp":1648672182000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/29\/4\/678\/6414894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,31]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,10,31]]},"published-print":{"date-parts":[[2022,3,30]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwab181","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2021,10,31]]}}}