{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:46:37Z","timestamp":1790304397915,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2018-02597"],"award-info":[{"award-number":["2018-02597"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2016-01001"],"award-info":[{"award-number":["2016-01001"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2018-02527"],"award-info":[{"award-number":["2018-02527"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heart-Lung Foundation","award":["20190624"],"award-info":[{"award-number":["20190624"]}]},{"name":"Heart-Lung Foundation","award":["20190404"],"award-info":[{"award-number":["20190404"]}]},{"name":"Heart-Lung Foundation","award":["2018-0589"],"award-info":[{"award-number":["2018-0589"]}]},{"name":"Swedish state under the agreement between the Swedish government and the county councils"},{"name":"ALF-agreement","award":["ALFGBG-723791"],"award-info":[{"award-number":["ALFGBG-723791"]}]},{"name":"ALF-agreement","award":["ALFGBG-720331"],"award-info":[{"award-number":["ALFGBG-720331"]}]},{"name":"Lundberg Foundation","award":["2017-0081"],"award-info":[{"award-number":["2017-0081"]}]},{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derberg Foundation","doi-asserted-by":"publisher","award":["M65\/15"],"award-info":[{"award-number":["M65\/15"]}],"id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF180C0033898"],"award-info":[{"award-number":["NNF180C0033898"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["KAW2015.0317"],"award-info":[{"award-number":["KAW2015.0317"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Hospitalizations for heart failure among young adults and middle-aged individuals have increased. The aims of the present study were to evaluate the association between birth weight and risk of adult heart failure and the importance of change from low birth weight to overweight\/obesity at young adulthood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We used the population-based body mass index (BMI) Epidemiology Study cohort Gothenburg (n\u2009=\u200935\u2009659) with birth weight and young adult BMI (20\u2009years) available from child healthcare records, school health records, and military conscription register for men born 1945\u20131961. The cohort includes all children who finished school, which was mandatory, in Gothenburg, Sweden. Information on heart failure diagnosis was retrieved from the National Patient Register and the Cause of Death Register (n\u2009=\u2009415). In cox regression analyses, there was an inverse association between birth weight and risk of heart failure [hazard ratio (HR) 0.83 per standard deviation (SD), 95% confidence interval (CI) 0.76\u20130.90], and a direct association for young adult BMI (HR 1.48 per SD, 95% CI 1.36\u20131.61). Of note, individuals with birth weight in the lowest tertile, who were overweight\/obese in young adulthood had a five-fold risk of heart failure (HR 4.95, 95% CI 3.36\u20137.31) compared with individuals in the middle birth weight tertile who were normal weight at 20\u2009years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Birth weight was inversely associated with the risk of hospitalization due to heart failure. The combination of low birth weight and overweight\/obesity in young adulthood results in excess risk of heart failure beyond that of low birth weight or young adult overweight\/obesity separately. These findings indicate the need of a life course perspective in heart failure prevention and risk assessment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwab186","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:48:32Z","timestamp":1634690912000},"page":"971-978","source":"Crossref","is-referenced-by-count":13,"title":["Birth weight and young adult body mass index for predicting the risk of developing adult heart failure in men"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-8642","authenticated-orcid":false,"given":"Maria","family":"Bygdell","sequence":"first","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-2805","authenticated-orcid":false,"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"},{"name":"Department of Drug Treatment, Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Lilja","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Research and Development Primary Health Care and Kungsh\u00f6jd Pediatric Clinic, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-3860","authenticated-orcid":false,"given":"Jimmy","family":"Celind","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"},{"name":"Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Martikainen","sequence":"additional","affiliation":[{"name":"Bioinformatics Core Facility, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny M","family":"Kindblom","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Vita str\u00e5ket 11, 41345 Gothenburg, Sweden"},{"name":"Pediatric Clinical Research Center, Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"2022050613360859700_zwab186-B1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/CIRCOUTCOMES.110.957571","article-title":"Population impact of heart failure and the most common forms of cancer: a study of 1 162 309 hospital cases in Sweden (1988 to 2004)","volume":"3","author":"Stewart","year":"2010","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2022050613360859700_zwab186-B2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ehf2.12005","article-title":"Heart failure: preventing disease and death worldwide","volume":"1","author":"Ponikowski","year":"2014","journal-title":"ESC Heart Fail"},{"key":"2022050613360859700_zwab186-B3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/eurheartj\/eht278","article-title":"Heart failure in young adults: 20-year trends in hospitalization, aetiology, and case fatality in Sweden","volume":"35","author":"Barasa","year":"2014","journal-title":"Eur Heart J"},{"key":"2022050613360859700_zwab186-B4","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/CIRCULATIONAHA.116.025941","article-title":"Age-specific trends in incidence, mortality, and comorbidities of heart failure in Denmark, 1995 to 2012","volume":"135","author":"Christiansen","year":"2017","journal-title":"Circulation"},{"key":"2022050613360859700_zwab186-B5","first-page":"1926","article-title":"Body weight in adolescence and long-term risk of early heart failure in adulthood among men in Sweden","volume":"38","author":"Rosengren","year":"2017","journal-title":"Eur Heart J"},{"key":"2022050613360859700_zwab186-B6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/bmj.311.6998.171","article-title":"Fetal origins of coronary heart disease","volume":"311","author":"Barker","year":"1995","journal-title":"BMJ"},{"key":"2022050613360859700_zwab186-B7","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/eurjhf\/hfq069","article-title":"The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood","volume":"12","author":"Barker","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2022050613360859700_zwab186-B8","doi-asserted-by":"crossref","first-page":"e011524","DOI":"10.1161\/JAHA.118.011524","article-title":"Association of high birth weight with incident heart failure in the ARIC study","volume":"8","author":"Rashid","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2022050613360859700_zwab186-B9","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.jacc.2017.03.572","article-title":"Preterm birth and risk of heart failure up to early adulthood","volume":"69","author":"Carr","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2022050613360859700_zwab186-B10","volume-title":"Skolhygienens Historia","author":"Herlitz","year":"1961"},{"key":"2022050613360859700_zwab186-B11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S2213-8587(16)30273-X","article-title":"Association between excessive BMI increase during puberty and risk of cardiovascular mortality in adult men: a population-based cohort study","volume":"4","author":"Ohlsson","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2022050613360859700_zwab186-B12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11936-019-0712-9","article-title":"Preterm birth is a novel, independent risk factor for altered cardiac remodeling and early heart failure: is it time for a new cardiomyopathy?","volume":"21","author":"Burchert","year":"2019","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"2022050613360859700_zwab186-B13"},{"key":"2022050613360859700_zwab186-B14","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1097\/AOG.0000000000003606","article-title":"Macrosomia: ACOG practice bulletin, number 216","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2022050613360859700_zwab186-B15","year":"2015"},{"key":"2022050613360859700_zwab186-B16","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1136\/bmj.322.7292.949","article-title":"Early growth and coronary heart disease in later life: longitudinal study","volume":"322","author":"Eriksson","year":"2001","journal-title":"BMJ"},{"key":"2022050613360859700_zwab186-B17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/01.STR.0000254471.72186.03","article-title":"Infant growth and stroke in adult life: the Helsinki birth cohort study","volume":"38","author":"Osmond","year":"2007","journal-title":"Stroke"},{"key":"2022050613360859700_zwab186-B18","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/bmj.298.6673.564","article-title":"Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease","volume":"298","author":"Barker","year":"1989","journal-title":"BMJ"},{"key":"2022050613360859700_zwab186-B19","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1007\/s00125-006-0459-1","article-title":"Patterns of growth among children who later develop type 2 diabetes or its risk factors","volume":"49","author":"Eriksson","year":"2006","journal-title":"Diabetologia"},{"key":"2022050613360859700_zwab186-B20","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/apa.12257","article-title":"Foetal and childhood growth and asthma in adult life","volume":"102","author":"Barker","year":"2013","journal-title":"Acta Paediatr"},{"key":"2022050613360859700_zwab186-B21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/EDE.0b013e31816339c6","article-title":"Weight at birth and all-cause mortality in adulthood","volume":"19","author":"Baker","year":"2008","journal-title":"Epidemiology"},{"key":"2022050613360859700_zwab186-B22","doi-asserted-by":"crossref","first-page":"iii14","DOI":"10.1136\/hrt.2005.070342","article-title":"Gender and heart failure: a population perspective","volume":"92","author":"Mehta","year":"2006","journal-title":"Heart"},{"key":"2022050613360859700_zwab186-B23","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1016\/j.numecd.2021.05.017","article-title":"Association between birth weight and risk of cardiovascular disease: evidence from UK Biobank","volume":"31","author":"Liang","year":"2021","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2022050613360859700_zwab186-B24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/joim.12741","article-title":"BMI change during puberty and the risk of heart failure","volume":"283","author":"Kindblom","year":"2018","journal-title":"J Intern Med"},{"key":"2022050613360859700_zwab186-B25","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1177\/2047487319882510","article-title":"Body mass index in women aged 18 to 45 and subsequent risk of heart failure","volume":"27","author":"Bj\u00f6rck","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"2022050613360859700_zwab186-B26","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1161\/CIRCULATIONAHA.110.012575","article-title":"Long-term follow-up of participants with heart failure in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)","volume":"124","author":"Piller","year":"2011","journal-title":"Circulation"},{"key":"2022050613360859700_zwab186-B27","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.amjmed.2009.04.022","article-title":"Risk factors for heart failure: a population-based case-control study","volume":"122","author":"Dunlay","year":"2009","journal-title":"Am J Med"},{"key":"2022050613360859700_zwab186-B28","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1440-1681.2011.05649.x","article-title":"Early origins of heart disease: low birth weight and determinants of cardiomyocyte endowment","volume":"39","author":"Botting","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2022050613360859700_zwab186-B29","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cardfail.2018.11.011","article-title":"Heart failure in low-income and middle-income countries: rising burden, diverse etiology, and high mortality","volume":"24","author":"Mensah","year":"2018","journal-title":"J Card Fail"},{"key":"2022050613360859700_zwab186-B30","first-page":"36","article-title":"Validity of heart failure diagnoses made in 2000-2012 in western Sweden","volume":"7","author":"Schaufelberger","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2022050613360859700_zwab186-B31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejheart.2004.12.007","article-title":"The validity of a diagnosis of heart failure in a hospital discharge register","volume":"7","author":"Ingelsson","year":"2005","journal-title":"Eur J Heart Fail"}],"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/29\/6\/971\/43589575\/zwab186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/29\/6\/971\/43589575\/zwab186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T13:38:24Z","timestamp":1651844304000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/29\/6\/971\/6463023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,12,15]]},"published-print":{"date-parts":[[2022,5,6]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwab186","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2021,12,15]]}}}