{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T14:59:57Z","timestamp":1786201197785,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Accumulating evidence questions the clinical value of percutaneous coronary intervention (PCI) for patients with chronic coronary syndrome (CCS). We therefore compare the impact of exercise-based cardiac rehabilitation (CR) vs. PCI in patients with CCS on 18-month mortality and morbidity, and evaluate the effects of combining PCI with exercise-based CR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A retrospective cohort study was conducted in March 2021. An online, real-world dataset of CCS patients was acquired, utilizing TriNetX, a global federated health research network. Patients with CCS who received PCI were first compared with patients who were prescribed exercise-based CR. Second, we compared patients who received both CR + PCI vs. CR alone. For both comparisons, patients were propensity-score matched by age, sex, race, comorbidities, medications, and procedures. We ascertained 18-month incidence of all-cause mortality, rehospitalization, and cardiovascular comorbidity [stroke, acute myocardial infarction (AMI), and new-onset heart failure]. The initial cohort consisted of 18\u200a383 CCS patients. Following propensity score matching, exercise-based CR was associated with significantly lower odds of all-cause mortality [0.37 (95% confidence interval (CI): 0.29\u20130.47)], rehospitalization [0.29 (95% CI: 0.27\u20130.32)], and cardiovascular morbidities, compared to PCI. Subsequently, patients that received both CR + PCI did not have significantly different odds for all-cause mortality [1.00 (95% CI: 0.63\u20131.60)], rehospitalization [1.00 (95% CI: 0.82\u20131.23)], AMI [1.11 (95% CI: 0.68\u20131.81)], and stroke [0.71 (95% CI: 0.39\u20131.31)], compared to CR only.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Compared to PCI, exercise-based CR associated with significantly lower odds of 18-month all-cause mortality, rehospitalization, and cardiovascular morbidity in patients with CCS, whilst combining PCI and exercise-based CR associated with lower incident heart failure only.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwab191","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T19:11:55Z","timestamp":1635534715000},"page":"1074-1080","source":"Crossref","is-referenced-by-count":28,"title":["Exercise-based cardiac rehabilitation vs. percutaneous coronary intervention for chronic coronary syndrome: impact on morbidity and mortality"],"prefix":"10.1093","volume":"29","author":[{"given":"Benjamin J R","family":"Buckley","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital , William Henry Duncan Building , Liverpool L7 8TX, UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-3657","authenticated-orcid":false,"given":"Iris A","family":"de Koning","sequence":"additional","affiliation":[{"name":"Department of Physiology, Research Institute for Health Science, Radboud University Medical Centrum , P.O. Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L","family":"Harrison","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital , William Henry Duncan Building , Liverpool L7 8TX, UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnara","family":"Fazio-Eynullayeva","sequence":"additional","affiliation":[{"name":"TriNetX Inc. ,\u00a0125 Cambridgepark Drive, Suite 500 Cambridge, MA 02140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Underhill","sequence":"additional","affiliation":[{"name":"TriNetX Inc. , London, England EC3V 4AB, GB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hareld M C","family":"Kemps","sequence":"additional","affiliation":[{"name":"Department of Cardiology, M\u00e1xima Medical Centre , Veldhoven, Dominee Theodor Fliednerstraat 1, 5631 BM Eindhoven, The Netherlands"},{"name":"Department of Industrial Design, Eindhoven University of Technology , Dominee Theodor Fliednerstraat 1, 5631, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital , William Henry Duncan Building , Liverpool L7 8TX, UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool L7 8TX, UK"},{"name":"Liverpool Centre for Cardiovascular Science, Liverpool John Moores University , Liverpool L3 3AF, UK"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University , S\u00f8ndre Skovvej 15, Forskningens Hus 9000, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick H J","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Research Institute for Health Science, Radboud University Medical Centrum , P.O. 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