{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:22:15Z","timestamp":1769016135970,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81960664"],"award-info":[{"award-number":["81960664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Applied Basic Research Program Yunnan Province of China","award":["202101AY070001-300"],"award-info":[{"award-number":["202101AY070001-300"]}]},{"name":"the Young and Middle-aged Academic and Technical Leaders Reserve Talent Project of Yunnan Province","award":["2019HB045"],"award-info":[{"award-number":["2019HB045"]}]},{"name":"the Science and Technology Program of 920th Hospital of Joint Logistics Support Force","award":["2020YGB11"],"award-info":[{"award-number":["2020YGB11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Previous studies reported that histamine H2 receptor antagonists (H2RAs) had cardioprotective effects. However, the effect of H2RAs on mortality of critical ill patients with heart failure (HF) remains unclear. The aim of this study was to clarify the association between H2RAs and all-cause mortality of critical ill patients with HF based on Medical Information Mart for Intensive Care III database (MIMIC-III).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Propensity score matching (PSM) was applied to account for the baseline differences between two groups that were exposed to H2RAs or not. The study primary outcome was all-cause mortality. Kaplan\u2013Meier curves and multivariable Cox regression models were employed to estimate the effects of H2RAs on mortality of critical ill patients with HF. A total of 10 387 patients were included, involving 4440 H2RAs users and 5947 non-H2RAs users. After matching, 3130 pairs of patients were matched between H2RAs users and non-H2RAs users. The results showed significant association between H2RAs exposure and decreased 30-day, 90-day, and 1-year mortality in both univariate analyses and multivariate analyses [hazard ratio (HR) = 0.73, 95% confidence interval (CI): 0.65\u20130.83 for 30-day; HR = 0.80, 95%CI: 0.72\u20130.89 for 90-day; and HR = 0.83, 95%CI: 0.76\u20130.90 for 1-year mortality, respectively] by Cox regression after PSM. Furthermore, stratified analyses revealed that the 30-day, 90-day, and 1-year mortality of ranitidine users were significantly lower than those of famotidine users, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Histamine H2 receptor antagonists exposure was associated with lower mortality in critical ill patients with HF. Furthermore, ranitidine might be superior to famotidine in reducing mortality of critical ill patients with HF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwac122","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T08:30:44Z","timestamp":1655368244000},"page":"1854-1865","source":"Crossref","is-referenced-by-count":22,"title":["Histamine H2 receptor antagonist exposure was related to decreased all-cause mortality in critical ill patients with heart failure: a cohort study"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-6657","authenticated-orcid":false,"given":"Yan-Hua","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, 920th Hospital of Joint Logistics Support Force , 212 Daguan Road, Kunming 650032 , China"},{"name":"Dali University , Dali 671000 , 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Road, Kunming 650032 , China"},{"name":"Dali University , Dali 671000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, 920th Hospital of Joint Logistics Support Force , 212 Daguan Road, Kunming 650032 , China"},{"name":"Dali University , Dali 671000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, 920th Hospital of Joint Logistics Support Force , 212 Daguan Road, Kunming 650032 , China"},{"name":"Dali University , Dali 671000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, 920th Hospital of Joint Logistics Support Force , 212 Daguan Road, Kunming 650032 , 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