{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:25:38Z","timestamp":1792794338099,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82103917"],"award-info":[{"award-number":["82103917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82020108028"],"award-info":[{"award-number":["82020108028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Research Project of Jiangsu Provincial Higher Education","award":["21KJB330006"],"award-info":[{"award-number":["21KJB330006"]}]},{"name":"Young Talent Support Project of Suzhou Association for Science and Technology","id":[{"id":"https:\/\/ror.org\/03ab2g513","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sleep disorders are associated with an increased risk of cardiometabolic diseases in observational studies, but the causality remains unclear. In this study, we leveraged two-sample Mendelian randomization (MR) analyses to assess the causal associations of self-reported daytime napping, daytime sleepiness, and other sleep phenotypes with cardiometabolic diseases including ischaemic stroke (IS), coronary artery disease (CAD), heart failure (HF), and Type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We selected genetic variants as instrumental variables for self-reported daytime napping, daytime sleepiness, morning person, insomnia, short sleep duration, and long sleep duration from European-descent genome-wide association studies (GWASs). Summary statistics for cardiometabolic diseases originated from four different GWASs with a total of 2 500 086 participants. We used the inverse-variance weighted method to explore the role of self-reported sleep phenotypes on the aetiology of cardiometabolic diseases in the main analyses, followed by several sensitivity analyses for robustness validation. Genetically predicted self-reported daytime napping [T2DM: OR, 1.56 (95% confidence interval, 1.21\u20132.02)], insomnia [IS: OR, 1.07 (1.04\u20131.11)]; CAD: OR, 1.13 (1.08\u20131.17); HF: OR, 1.10 (1.07\u20131.14); T2DM: OR, 1.16 (1.11\u20131.22); and short sleep duration [CAD: OR, 1.37 (1.21\u20131.55)] were causally associated with an elevated risk of cardiometabolic diseases. Moreover, genetically determined self-reported daytime sleepiness [CAD: OR, 2.05 (1.18\u20133.57); HF: OR, 1.82 (1.15\u20132.87)] and morning person [HF: 1.06 OR, (1.01\u20131.11)] had potential detrimental effect on cardiometabolic risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Self-reported daytime napping, insomnia, and short sleep duration had causal roles in the development of cardiometabolic diseases, while self-reported daytime sleepiness and morning person was the potential risk factor for cardiometabolic diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwac123","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T04:40:02Z","timestamp":1655354402000},"page":"1982-1991","source":"Crossref","is-referenced-by-count":55,"title":["Self-reported daytime napping, daytime sleepiness, and other sleep phenotypes in the development of cardiometabolic diseases: a Mendelian randomization study"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-7879","authenticated-orcid":false,"given":"Yiming","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoxia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"},{"name":"School of Nursing, Medical College of Soochow University , Suzhou, Jiangsu Province 215006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinni","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-7357","authenticated-orcid":false,"given":"Zhengbao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University , 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province 215123 , 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