{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:01:40Z","timestamp":1791054100620,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Heart Centre Hasselt"},{"DOI":"10.13039\/501100009550","name":"Hasselt University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009550","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To compare the cardiac function and pulmonary vascular function during exercise between dyspnoeic and non-dyspnoeic patients with Type 2 diabetes mellitus (T2DM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Forty-seven T2DM patients with unexplained dyspnoea and 50 asymptomatic T2DM patients underwent exercise echocardiography combined with ergospirometry. Left ventricular (LV) function [stroke volume, cardiac output (CO), LV ejection fraction, systolic annular velocity (s\u2032)], estimated LV filling pressures (E\/e\u2032), mean pulmonary arterial pressures (mPAPs) and mPAP\/COslope were assessed at rest, low- and high-intensity exercise with colloid contrast. Groups had similar patient characteristics, glycemic control, stroke volume, CO, LV ejection fraction, and E\/e\u2032 (P &amp;gt; 0.05). The dyspnoeic group had significantly lower systolic LV reserve at peak exercise (s\u2032) (P = 0.021) with a significant interaction effect (P &amp;lt; 0.001). The dyspnoeic group also had significantly higher mPAP and mPAP\/CO at rest and exercise (P &amp;lt; 0.001) with significant interaction for mPAP (P &amp;lt; 0.009) and insignificant for mPAP\/CO (P = 0.385). There was no significant difference in mPAP\/COslope between groups (P = 0.706). However, about 61% of dyspnoeic vs. 30% of non-dyspnoeic group had mPAP\/COslope &amp;gt; 3 (P = 0.009). The mPAP\/COslope negatively predicted V\u0307O2peak in dyspneic group (\u03b2 = \u22121.86, 95% CI: \u22122.75, \u22120.98; multivariate model R2:0.54).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pulmonary hypertension and less LV systolic reserve detected by exercise echocardiography with colloid contrast underlie unexplained exertional dyspnoea and reduced exercise capacity in T2DM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwac153","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T17:59:05Z","timestamp":1658858345000},"page":"37-45","source":"Crossref","is-referenced-by-count":10,"title":["Pulmonary hypertension during exercise underlies unexplained exertional dyspnoea in patients with Type 2 diabetes"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2893-8629","authenticated-orcid":false,"given":"Tin","family":"Gojevic","sequence":"first","affiliation":[{"name":"REVAL - Rehabilitation Research Centre, Faculty of Rehabilitation Sciences, Hasselt University , Agoralaan, Building A, 3590 Diepenbeek , Belgium"},{"name":"BIOMED - Biomedical Research Centre, Faculty of Medicine and Life Sciences, Hasselt University , 3500 Diepenbeek , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-0034","authenticated-orcid":false,"given":"Lisa","family":"Van Ryckeghem","sequence":"additional","affiliation":[{"name":"REVAL - Rehabilitation Research Centre, Faculty of Rehabilitation Sciences, Hasselt University , Agoralaan, Building A, 3590 Diepenbeek , Belgium"},{"name":"BIOMED - Biomedical Research Centre, Faculty of Medicine and Life Sciences, Hasselt University , 3500 Diepenbeek , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-197X","authenticated-orcid":false,"given":"Siddharth","family":"Jogani","sequence":"additional","affiliation":[{"name":"Jessa Hospital, Heart Centre Hasselt , 3500 Hasselt , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-5972","authenticated-orcid":false,"given":"Ines","family":"Frederix","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zuyderland MC , 6419 PC Heerlen , The Netherlands"},{"name":"Faculty of Medicine and Health Sciences, Antwerp University , 2610 WILRIJK (Antwerpen) , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0824-0506","authenticated-orcid":false,"given":"Elise","family":"Bakelants","sequence":"additional","affiliation":[{"name":"Jessa Hospital, Heart Centre Hasselt , 3500 Hasselt , Belgium"},{"name":"Department of Cardiology, Geneva University Hospital , 1205 Gen\u00e8ve , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-8438","authenticated-orcid":false,"given":"Thibault","family":"Petit","sequence":"additional","affiliation":[{"name":"Jessa Hospital, Heart Centre Hasselt , 3500 Hasselt , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Stroobants","sequence":"additional","affiliation":[{"name":"Jessa Hospital, Heart Centre Hasselt , 3500 Hasselt , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-4559","authenticated-orcid":false,"given":"Paul","family":"Dendale","sequence":"additional","affiliation":[{"name":"BIOMED - Biomedical Research Centre, Faculty of Medicine and Life Sciences, Hasselt University , 3500 Diepenbeek , Belgium"},{"name":"Jessa Hospital, Heart Centre Hasselt , 3500 Hasselt , Belgium"},{"name":"Faculty of Medicine 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