{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:55:05Z","timestamp":1788414905977,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-aid for Scientific Research","doi-asserted-by":"crossref","award":["A13307016"],"award-info":[{"award-number":["A13307016"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-aid for Scientific Research","doi-asserted-by":"crossref","award":["A17209023"],"award-info":[{"award-number":["A17209023"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-aid for Scientific Research","doi-asserted-by":"crossref","award":["A21249043"],"award-info":[{"award-number":["A21249043"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-aid for Scientific Research","doi-asserted-by":"crossref","award":["A23249036"],"award-info":[{"award-number":["A23249036"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-aid for Scientific Research","doi-asserted-by":"crossref","award":["A25253046"],"award-info":[{"award-number":["A25253046"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-aid for Scientific Research","doi-asserted-by":"crossref","award":["A15H02528"],"award-info":[{"award-number":["A15H02528"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-aid for Scientific Research","doi-asserted-by":"crossref","award":["18H04074"],"award-info":[{"award-number":["18H04074"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL068200"],"award-info":[{"award-number":["R01HL068200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The potential effect of alcohol consumption on coronary heart disease (CHD) remains unclear. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate the causal role of alcohol intake in subclinical and clinical CHD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted two Mendelian randomization studies: a cross-sectional study of coronary artery calcification (CAC) on computed tomography of 1029 healthy men (mean age, 63.8 years) and a case\u2013control study of 421 men with CHD [acute coronary syndrome (ACS) or stable angina pectoris] who underwent coronary revascularization and 842 age-matched male controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the CAC study, medians (25%tiles, 75%tiles) of alcohol consumption by ALDH2-rs671 *2 homozygotes [n = 86 (8.4%)], *1*2 heterozygotes [n = 397 (38.5%)], and *1 homozygotes [n = 546 (53.1%)] were 0.0 (0.0, 0.0), 28.0 (0.0, 129.0), and 224.0 (84.0, 350.0) g\/week, respectively. In age-adjusted Poisson regression with robust error variance, compared with *2 homozygotes, relative risks for prevalent CAC score &amp;gt;0, \u2265100, and \u2265300 in *1 homozygotes were 1.29 (95% confidence interval, 1.06\u20131.57), 1.76 (1.05\u20132.96), and 1.81 (0.80\u20134.09), respectively. In age-adjusted ordinal logistic regression for CAC distributions, we observed higher odds among *1 homozygotes [odds ratio, 2.19 (1.39\u20133.46)] and even among *1*2 heterozygotes [1.77 (1.11\u20132.82)] compared with *2 homozygotes. In the case\u2013control study, conditional logistic regression revealed lower prevalence of *1 homozygotes among men with CHD [odds ratio, 0.54 (0.35\u20130.82)], especially ACS [0.46 (0.27\u20130.77)], than controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings indicate a positive association of alcohol consumption with CAC burden but an inverse association with clinical CHD, especially ACS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwac156","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T18:29:42Z","timestamp":1659205782000},"page":"2006-2014","source":"Crossref","is-referenced-by-count":19,"title":["Alcohol consumption and subclinical and clinical coronary heart disease: a Mendelian randomization analysis"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-1763","authenticated-orcid":false,"given":"Takashi","family":"Hisamatsu","sequence":"first","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"},{"name":"Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-9582","authenticated-orcid":false,"given":"Katsuyuki","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"},{"name":"NCD Epidemiology Research Center, Shiga University of Medical Science , Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Tabara","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"},{"name":"Graduate School of Public Health, Shizuoka Graduate University of Public Health , Shizuoka 420-0881 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-0056","authenticated-orcid":false,"given":"Yuichi","family":"Sawayama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Kadota","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuki","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"},{"name":"NCD Epidemiology Research Center, Shiga University of Medical Science , Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fujiyoshi","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"},{"name":"Department of Hygiene, Wakayama Medical University , Wakayama 641-8509 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Otsu 520-2192 , Japan"},{"name":"Division of Cardiology, Department of Internal Medicine, Kohka Public Hospital , Kohka 528-0074 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-2339","authenticated-orcid":false,"given":"Minoru","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science , Otsu 520-2192 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine , Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"},{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Tokyo 160-8582 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-4253","authenticated-orcid":false,"given":"Hirotsugu","family":"Ueshima","sequence":"additional","affiliation":[{"name":"Department of Public Health, Shiga University of Medical Science , Seta-Tsukinowa-cho, Otsu 520-2192 , Japan"},{"name":"Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama 700-8558 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the SESSA and ACCESS Research Groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"2022110818084880800_zwac156-B1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1360-0443.2010.02899.x","article-title":"The relation between different dimensions of alcohol consumption and burden of disease: an overview","volume":"105","author":"Rehm","year":"2010","journal-title":"Addiction"},{"key":"2022110818084880800_zwac156-B2","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/CIRCULATIONAHA.105.568030","article-title":"Alcohol and coronary heart disease: the answer awaits a randomized controlled trial","volume":"112","author":"Freiberg","year":"2005","journal-title":"Circulation"},{"key":"2022110818084880800_zwac156-B3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jacc.2007.04.089","article-title":"Alcohol and cardiovascular health: the razor-sharp double-edged sword","volume":"50","author":"O'Keefe","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2022110818084880800_zwac156-B4","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(18)30134-X","article-title":"Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies","volume":"391","author":"Wood","year":"2018","journal-title":"Lancet"},{"key":"2022110818084880800_zwac156-B5","doi-asserted-by":"crossref","first-page":"j909","DOI":"10.1136\/bmj.j909","article-title":"Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records","volume":"356","author":"Bell","year":"2017","journal-title":"BMJ"},{"key":"2022110818084880800_zwac156-B6","doi-asserted-by":"crossref","first-page":"d636","DOI":"10.1136\/bmj.d636","article-title":"Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies","volume":"342","author":"Brien","year":"2011","journal-title":"BMJ"},{"key":"2022110818084880800_zwac156-B7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.atherosclerosis.2016.08.021","article-title":"Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers","volume":"254","author":"Tabara","year":"2016","journal-title":"Atherosclerosis"},{"key":"2022110818084880800_zwac156-B8","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3945\/ajcn.2008.26420","article-title":"Alcohol and coronary artery calcium prevalence, incidence, and progression: results from the multi-ethnic study of atherosclerosis (MESA)","volume":"88","author":"McClelland","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"2022110818084880800_zwac156-B9","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1001\/archinte.164.21.2355","article-title":"Alcohol consumption and coronary calcification in a general population","volume":"164","author":"Vliegenthart","year":"2004","journal-title":"Arch Intern Med"},{"key":"2022110818084880800_zwac156-B10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/aje\/kwi062","article-title":"Alcohol consumption, binge drinking, and early coronary calcification: findings from the coronary artery risk development in young adults (CARDIA) study","volume":"161","author":"Pletcher","year":"2005","journal-title":"Am J Epidemiol"},{"key":"2022110818084880800_zwac156-B11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2147\/vhrm.2006.2.3.239","article-title":"Effect of alcohol on risk of coronary heart disease and stroke: causality, bias, or a bit of both?","volume":"2","author":"Emberson","year":"2006","journal-title":"Vasc Health Risk Manag"},{"key":"2022110818084880800_zwac156-B12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.15288\/jsad.2017.78.375","article-title":"Alcohol consumption and mortality from coronary heart disease: an updated meta-analysis of cohort studies","volume":"78","author":"Zhao","year":"2017","journal-title":"J Stud Alcohol Drugs"},{"key":"2022110818084880800_zwac156-B13","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/S0140-6736(05)67767-7","article-title":"Nature's randomised trials","volume":"366","author":"Hingorani","year":"2005","journal-title":"Lancet"},{"key":"2022110818084880800_zwac156-B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u2018Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int J Epidemiol"},{"key":"2022110818084880800_zwac156-B15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10654-020-00622-7","article-title":"Mendel's laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues","volume":"35","author":"Smith G","year":"2020","journal-title":"Eur J Epidemiol"},{"key":"2022110818084880800_zwac156-B16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/sj.jhh.1001605","article-title":"Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: the INTERMAP study","volume":"17","author":"Zhou","year":"2003","journal-title":"J Hum Hypertens"},{"key":"2022110818084880800_zwac156-B17","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1126\/science.1158554","article-title":"Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart","volume":"321","author":"Chen","year":"2008","journal-title":"Science"},{"key":"2022110818084880800_zwac156-B18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1530-0277.1996.tb01080.x","article-title":"Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese","volume":"20","author":"Higuchi","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"2022110818084880800_zwac156-B19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.atherosclerosis.2015.12.027","article-title":"Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population","volume":"246","author":"Ueshima","year":"2016","journal-title":"Atherosclerosis"},{"key":"2022110818084880800_zwac156-B20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1253\/circj.CJ-19-0133","article-title":"JCS 2018 Guideline on diagnosis and treatment of acute coronary syndrome","volume":"83","author":"Kimura","year":"2019","journal-title":"Circ J"},{"key":"2022110818084880800_zwac156-B21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1253\/circj.CJ-19-1131","article-title":"JCS 2018 Guideline on diagnosis of chronic coronary heart diseases","volume":"85","author":"Yamagishi","year":"2021","journal-title":"Circ J"},{"key":"2022110818084880800_zwac156-B22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.jhh.1001627","article-title":"Specific alcoholic beverage and blood pressure in a middle-aged Japanese population: the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study","volume":"18","author":"Okamura","year":"2004","journal-title":"J Hum Hypertens"},{"key":"2022110818084880800_zwac156-B23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"2022110818084880800_zwac156-B24","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/aje\/kwh090","article-title":"A modified poisson regression approach to prospective studies with binary data","volume":"159","author":"Zou","year":"2004","journal-title":"Am J Epidemiol"},{"key":"2022110818084880800_zwac156-B25","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJMoa072100","article-title":"Coronary calcium as a predictor of coronary events in four racial or ethnic groups","volume":"358","author":"Detrano","year":"2008","journal-title":"N Engl J Med"},{"key":"2022110818084880800_zwac156-B26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/jama.291.2.210","article-title":"Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals","volume":"291","author":"Greenland","year":"2004","journal-title":"JAMA"},{"key":"2022110818084880800_zwac156-B27","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0140-6736(18)31772-0","article-title":"Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China","volume":"393","author":"Millwood","year":"2019","journal-title":"Lancet"},{"key":"2022110818084880800_zwac156-B28","doi-asserted-by":"crossref","first-page":"e7703","DOI":"10.1590\/1414-431x20187703","article-title":"Red wine consumption, coronary calcification, and long-term clinical evolution","volume":"51","author":"da Luz","year":"2018","journal-title":"Braz J Med Biol Res"},{"key":"2022110818084880800_zwac156-B29","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1136\/bmj.319.7224.1523","article-title":"Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors","volume":"319","author":"Rimm","year":"1999","journal-title":"BMJ"},{"key":"2022110818084880800_zwac156-B30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1055\/s-0037-1613153","article-title":"Differential effects of moderate or heavy alcohol consumption on circulating adhesion molecule levels","volume":"88","author":"Sacanella","year":"2002","journal-title":"Thromb Haemost"},{"key":"2022110818084880800_zwac156-B31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0140-6736(00)04170-2","article-title":"Effect of alcohol consumption on systemic markers of inflammation","volume":"357","author":"Imhof","year":"2001","journal-title":"Lancet"},{"key":"2022110818084880800_zwac156-B32","doi-asserted-by":"crossref","first-page":"H165","DOI":"10.1152\/ajpheart.00408.2001","article-title":"Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and akt","volume":"283","author":"Zhou","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022110818084880800_zwac156-B33","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1590\/1414-431x20143880","article-title":"Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence","volume":"47","author":"Luz","year":"2014","journal-title":"Braz J Med Biol Res"},{"key":"2022110818084880800_zwac156-B34","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1161\/hq1001.098463","article-title":"Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case\u2013control study","volume":"21","author":"Zhao","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022110818084880800_zwac156-B35","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jacc.2015.01.036","article-title":"Impact of statins on serial coronary calcification during atheroma progression and regression","volume":"65","author":"Puri","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2022110818084880800_zwac156-B36","doi-asserted-by":"crossref","first-page":"18422","DOI":"10.1038\/srep18422","article-title":"Alcohol intake and cardiovascular risk factors: a Mendelian randomisation study","volume":"5","author":"Cho","year":"2015","journal-title":"Sci Rep"},{"key":"2022110818084880800_zwac156-B37","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1111\/j.1582-4934.2010.01181.x","article-title":"Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome","volume":"15","author":"Xu","year":"2011","journal-title":"J Cell Mol Med"},{"key":"2022110818084880800_zwac156-B38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1291\/hypres.25.677","article-title":"Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men","volume":"25","author":"Takagi","year":"2002","journal-title":"Hypertens Res"},{"key":"2022110818084880800_zwac156-B39","doi-asserted-by":"crossref","first-page":"g4164","DOI":"10.1136\/bmj.g4164","article-title":"Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data","volume":"349","author":"Holmes","year":"2014","journal-title":"BMJ"}],"container-title":["European Journal of Preventive Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/advance-article-pdf\/doi\/10.1093\/eurjpc\/zwac156\/45292005\/zwac156.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/29\/15\/2006\/46874518\/zwac156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/29\/15\/2006\/46874518\/zwac156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T18:31:22Z","timestamp":1667932282000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/29\/15\/2006\/6652440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,30]]},"references-count":39,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,7,30]]},"published-print":{"date-parts":[[2022,11,8]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwac156","relation":{},"ISSN":["2047-4873","2047-4881"],"issn-type":[{"value":"2047-4873","type":"print"},{"value":"2047-4881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10,17]]},"published":{"date-parts":[[2022,7,30]]}}}