{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:44:43Z","timestamp":1784357083186,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of Health"},{"name":"Ministry of Health, Labour and Welfare, Japan","award":["19AA2007"],"award-info":[{"award-number":["19AA2007"]}]},{"name":"Ministry of Health, Labour and Welfare, Japan","award":["H30-Policy-Designated-004"],"award-info":[{"award-number":["H30-Policy-Designated-004"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","award":["17H04141"],"award-info":[{"award-number":["17H04141"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cancer survivors have a greater risk of cardiovascular disease (CVD). Although Life\u2019s Simple 7 is used for CVD risk stratification in a general population, its utility in cancer survivors remains unknown. We aimed to clarify the association of Life\u2019s Simple 7 with incident CVD among cancer survivors. Furthermore, we analyzed the relationship between the change in Life\u2019s Simple 7 and the subsequent CVD risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This retrospective observational study was conducted using the JMDC Claims Database, and we analyzed 53 974 patients with a prior history of breast, colorectal, or stomach cancer, which is a common cancer site in the Japanese population. The median age was 54 years, and 37.8% were men. We modified the original definition of Life\u2019s Simple 7 and identified the following ideal Life\u2019s Simple 7 cardiovascular health metrics: non-smoking, body mass index &amp;lt; 25\u2005kg\/m2, physical activity at goal, optimal dietary habits, untreated fasting plasma glucose &amp;lt; 100\u2005mg\/dL, untreated blood pressure &amp;lt; 120\/80\u2005mmHg, and untreated total cholesterol &amp;lt; 200\u2005mg\/dL. The primary endpoint was composite CVD outcome, including myocardial infarction, angina pectoris, stroke, and heart failure. Over a mean follow-up period of 975 \u00b1 794 days, 3150 composite CVD outcomes were recorded. The risk of CVD events increased with a greater number of non-ideal Life\u2019s Simple 7. The hazard ratio per 1-point increase in non-ideal Life\u2019s Simple 7 was 1.15 [95% confidence interval (CI): 1.12\u20131.18). Furthermore, a 1-point increase in non-ideal Life\u2019s Simple 7 over 1 year was associated with subsequent CVD risk (hazard ratio: 1.12, 95% CI: 1.06\u20131.19).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Life\u2019s Simple 7 could be applicable for CVD risk stratification even among cancer survivors. Optimizing Life\u2019s Simple 7 may prevent the development of CVD in cancer survivors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwac195","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T12:49:59Z","timestamp":1661950199000},"page":"2324-2332","source":"Crossref","is-referenced-by-count":34,"title":["Association of Life\u2019s Simple 7 with incident cardiovascular disease in 53 974 patients with cancer"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6170","authenticated-orcid":false,"given":"Hidehiro","family":"Kaneko","sequence":"first","affiliation":[{"name":"The Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"},{"name":"The Department of Advanced Cardiology, The University of Tokyo , 7-3-1, Hongo, Bunkyo-ku, 113-8655 Tokyo , 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