{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:24:53Z","timestamp":1793319893450,"version":"4.5.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of Health"},{"name":"Labour and Welfare"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Data on the dose-dependent association of blood pressure (BP) and fasting plasma glucose (FPG) level with the risk of aortic dissection (AD) and aortic aneurysm (AA) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This observational cohort study included 3 358 293 individuals registered in a health checkup and claims database in Japan [median age, 43 (36\u201351) years; 57.2% men]. Individuals using BP- or glucose-lowering medications or those with a history of cardiovascular disease were excluded. In a mean follow-up period of 1 199 \u00b1 950 days, 1 095 and 2 177 cases of AD and AA, respectively, were recorded. Compared with normal\/elevated BP, hazard ratios (HRs) of Stage 1 and Stage 2 hypertension were 1.89 [95% confidence interval (CI): 1.60\u20132.22] and 5.87 (95% CI: 5.03\u20136.84) for AD and 1.37 (95% CI: 1.23\u20131.52) and 2.17 (95% CI: 1.95\u20132.42) for AA, respectively. Compared with normal FPG level, HRs of prediabetes and diabetes were 0.82 (95% CI: 0.71\u20130.94) and 0.48 (95% CI: 0.33\u20130.71) for AD and 0.94 (95% CI: 0.85\u20131.03) and 0.61 (95% CI: 0.47\u20130.79) for AA, respectively. The cubic spline demonstrated that the risk of AD and AA increased with increasing BP but decreased with increasing FPG level. Contour plots using generalized additive models showed that higher systolic BP and lower FPG level were associated with an elevated risk of AD and AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our analysis showed a dose-dependent increase in the risk of AD or AA associated with BP and a similar decrease associated with FPG, and also suggested a potential interaction between hypertension and hyperglycaemia in the development of AD and AA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwac205","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T08:54:55Z","timestamp":1662540895000},"page":"2338-2346","source":"Crossref","is-referenced-by-count":29,"title":["Dose-dependent relationship of blood pressure and glycaemic status with risk of aortic dissection and aneurysm"],"prefix":"10.1093","volume":"29","author":[{"given":"Yuta","family":"Suzuki","sequence":"first","affiliation":[{"name":"The Department of Cardiovascular Medicine, The University of Tokyo , Tokyo 113-8655 , Japan"},{"name":"Center for Outcomes Research and Economic Evaluation for Health, National Institute of Public Health , Saitama 351-0197 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6170","authenticated-orcid":false,"given":"Hidehiro","family":"Kaneko","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, The University of Tokyo , Tokyo 113-8655 , Japan"},{"name":"The Department of Advanced Cardiology, The University of Tokyo , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Advanced Epidemiology, NCD Epidemiology Research Center, Shiga University 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University of Tokyo , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Takeda","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, The University of Tokyo , Tokyo 113-8655 , Japan"},{"name":"Marfan Syndrome Center, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Morita","sequence":"additional","affiliation":[{"name":"The Department of Cardiovascular Medicine, The University of Tokyo , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-2225","authenticated-orcid":false,"given":"Isao","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, Hokkaido University , Sapporo 060-0808 , 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