{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:36:32Z","timestamp":1773736592782,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Guidelines have lowered blood pressure (BP) targets to &amp;lt;130\/80 mmHg. We examined the benefit of intensive control for each BP component, vs. the burden of other modifiable risk factors, in patients with chronic coronary syndromes (CCS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The CLARIFY registry (ISRCTN43070564) enrolled 32 703 patients with CCS, from 2009 to 2010, with a 5-year follow-up. Patients with either BP component below European guideline safety boundaries (120\/70 mmHg) were excluded, leaving 19 167 patients (mean age: 63.8 \u00b1 10.1 years, 78% men) in the present analysis. A multivariable-adjusted Cox proportional hazards model showed a gradual increase in cardiovascular risk (cardiovascular death, myocardial infarction, or stroke) when the number of uncontrolled risk factors (active smoking, no physical activity, low-density lipoprotein cholesterol \u2265100 mg\/dL, and diabetes with glycated haemoglobin \u22657%) increased [adjusted hazard ratio (HR): 1.34; 95% confidence interval (CI): 1.17\u20131.52, 1.65 (1.40\u20131.94), and 2.47 (1.90\u20133.21) for 1, 2, and 3 or 4 uncontrolled risk factors, respectively, vs. 0], without significant interaction with BP. Although uncontrolled systolic (\u2265140 mmHg) and diastolic (\u226590 mmHg) BP were both associated with higher risk than standard BP, standard BP was associated with higher risk than optimal control for only the diastolic component (adjusted HR: 1.08; 95% CI: 0.94\u20131.25 for systolic BP 130\u2013139 vs. 120\u2013129 mmHg and 1.43; 95% CI: 1.27\u20131.62 for diastolic BP 80\u201389 vs. 70\u201379 mmHg).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggest that the optimal BP target in CCS may be \u2264139\/79 mmHg and that optimizing the burden of other risk factors should be prioritized over the further reduction of systolic BP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad004","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T08:48:14Z","timestamp":1673167694000},"page":"935-947","source":"Crossref","is-referenced-by-count":3,"title":["Optimal or standard control of systolic and diastolic blood pressure across risk factor categories in patients with chronic coronary syndromes"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9356-7302","authenticated-orcid":false,"given":"Emmanuelle","family":"Vidal-Petiot","sequence":"first","affiliation":[{"name":"Physiology Department, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bichat and INSERM U1149, Centre for Research in Inflammation , 46 rue Henri Huchard, 75018 Paris , France"},{"name":"Universit\u00e9 Paris-Cit\u00e9 , UFR de M\u00e9decine, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yedid","family":"Elbez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bichat , 46 rue Henri Huchard, 75018 Paris , France"},{"name":"FACT (French Alliance for Cardiovascular Trials) and INSERM U1148, Laboratory for Vascular Translational Science , 46, rue Henri Huchard, 75018 Paris , France"},{"name":"Biostat Signifience , 35 rue de l\u2019Oasis, 92800 Puteaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules","family":"Mesnier","sequence":"additional","affiliation":[{"name":"Cardiology Department, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bichat , 46 rue Henri Huchard, 75018 Paris , France"},{"name":"FACT (French Alliance for Cardiovascular Trials) and INSERM U1148, Laboratory for Vascular Translational Science , 46, rue Henri Huchard, 75018 Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4069-1128","authenticated-orcid":false,"given":"Gregory","family":"Ducrocq","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Cit\u00e9 , UFR de M\u00e9decine, Paris , France"},{"name":"Cardiology Department, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bichat , 46 rue Henri Huchard, 75018 Paris , France"},{"name":"FACT (French Alliance for Cardiovascular Trials) and INSERM U1148, Laboratory for Vascular Translational Science , 46, rue Henri Huchard, 75018 Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-1823","authenticated-orcid":false,"given":"Ian","family":"Ford","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics, Boyd Orr Building, University Avenue, University of Glasgow , Glasgow, G12 8QQ , 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