{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:57:31Z","timestamp":1777946251870,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To describe the practice patterns of evidence-based medical therapy (EBM) and overall mortality in high-risk patients with critical limb-threatening ischaemia (CLTI), compared with patients with myocardial infarction (MI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Using Danish registries, we identified patients 40\u2013100 years of age with a first-time hospitalization for CLTI or MI from 2008\u20132018 and grouped them into CLTI, MI, and CLTI and history of MI (CLTI + MI). We examined the likelihood of filling prescriptions with EBM [i.e. antiplatelets (Aps), lipid-lowering agents (LLAs), angiotensin-converting enzyme inhibitor (ACEi), or angiotensin II-receptor blockers (ARBs)] within 3 months after discharge among survivors. Further, we assessed the adjusted 3-year mortality rates. We included 92 845 patients: 14 941 with CLTI (54.7% male), 74 830 with MI (64.6% male) and 3,074 with CLTI + MI (65.2% male). Patients with CLTI and CLTI + MI were older and had more comorbidities than patients with MI. Compared with patients with MI, the unadjusted odds ratios of filling prescriptions were 0.15 [confidence interval (CI): 0.14\u20130.15] for AP, 0.26 (CI: 0.25\u20130.27) for LLA, and 0.71 (CI: 0.69\u20130.74) for ARB\/ACEi in patients with CLTI, and 0.22 (CI: 0.20\u20130.24) for AP, 0.38 (CI: 0.35\u20130.42) for LLA, and 1.17 (CI: 1.08\u20131.27) for ARB\/ACEi in patients with CLTI + MI. Adjusted analyses showed similar results. Compared with patients with MI, adjusted 3-year hazard ratios for mortality were 1.69 (CI: 1.64\u20131.74) in patients with CLTI and 1.60 (CI: 1.51\u20131.69) in patients with CLTI + MI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with CLTI were undertreated with EBM and carried a more adverse prognosis, as compared with patients with MI, despite similar guidelines.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad022","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T04:48:31Z","timestamp":1674622111000},"page":"1092-1100","source":"Crossref","is-referenced-by-count":11,"title":["The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9522-1580","authenticated-orcid":false,"given":"Lucas Grove Vejlstrup","family":"Bager","sequence":"first","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeppe Kofoed","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Havers-Borgersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Resch","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim G","family":"Smolderen","sequence":"additional","affiliation":[{"name":"Yale Medicine, Department of Internal Medicine, Section of Cardiovascular Medicine , 789 Howard Avenue, New Haven, CT 06519 , USA"},{"name":"Yale Medicine, Department of Psychiatry, Section of Psychology , 789 Howard Avenue, New Haven, CT 06519 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Mena-Hurtado","sequence":"additional","affiliation":[{"name":"Yale Medicine, Department of Internal Medicine, Section of Cardiovascular Medicine , 789 Howard Avenue, New Haven, CT 06519 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Eiberg","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Rigshospitalet, Copenhagen University Hospital , Blegdamsvej 9, 2100 Copenhagen , Denmark"},{"name":"Copenhagen Academy of Medical Education and Simulation 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