{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:45Z","timestamp":1792785885566,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002802","name":"Cardiff Metropolitan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009510","name":"University of Hull","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012324","name":"University Hospitals Coventry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013962","name":"Warwickshire NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013962","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Atrium Health"},{"DOI":"10.13039\/501100001313","name":"Coventry University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001313","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gwent Cardiac Rehab"},{"name":"Royal Gwent Cardiology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a lack of international consensus regarding the prescription of high-intensity interval training (HIIT) for people with coronary artery disease (CAD) attending cardiac rehabilitation (CR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the clinical effectiveness and safety of low-volume HIIT compared with moderate-intensity steady-state (MISS) exercise training for people with CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We conducted a multi-centre RCT, recruiting 382 patients from 6 outpatient CR centres. Participants were randomized to twice-weekly HIIT (n = 187) or MISS (n = 195) for 8 weeks. HIIT consisted of 10 \u00d7 1 min intervals of vigorous exercise (&amp;gt;85% maximum capacity) interspersed with 1 min periods of recovery. MISS was 20\u201340 min of moderate-intensity continuous exercise (60\u201380% maximum capacity). The primary outcome was the change in cardiorespiratory fitness [peak oxygen uptake (VO2 peak)] at 8 week follow-up. Secondary outcomes included cardiovascular disease risk markers, cardiac structure and function, adverse events, and health-related quality of life. At 8 weeks, VO2peak improved more with HIIT (2.37 mL.kg\u22121.min\u22121; SD, 3.11) compared with MISS (1.32 mL.kg\u22121.min\u22121; SD, 2.66). After adjusting for age, sex, and study site, the difference between arms was 1.04 mL.kg\u22121.min\u22121 (95% CI, 0.38 to 1.69; P = 0.002). Only one serious adverse event was possibly related to HIIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In stable CAD, low-volume HIIT improved cardiorespiratory fitness more than MISS by a clinically meaningful margin. Low-volume HIIT is a safe, well-tolerated, and clinically effective intervention that produces short-term improvement in cardiorespiratory fitness. It should be considered by all CR programmes as an adjunct or alternative to MISS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov: NCT02784873. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02784873.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad039","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T11:45:49Z","timestamp":1675770349000},"page":"745-755","source":"Crossref","is-referenced-by-count":85,"title":["High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-9107","authenticated-orcid":false,"given":"Gordon","family":"McGregor","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust , Clifford Bridge Road, Coventry CV1 3LN , UK"},{"name":"Centre for Sport Exercise & Life Sciences, Coventry University , Coventry , UK"},{"name":"Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick , Coventry , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust , Clifford Bridge Road, Coventry CV1 3LN , UK"},{"name":"Centre for Sport Exercise & Life Sciences, Coventry University , Coventry , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Begg","sequence":"additional","affiliation":[{"name":"Cardiff Centre for Exercise & Health, Cardiff Metropolitan University, Cardiff , UK"},{"name":"Cardiac Rehabilitation, Aneurin Bevan University Health Board , Gwent , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T","family":"Birkett","sequence":"additional","affiliation":[{"name":"Department of Sport and Exercise Sciences, Manchester Metropolitan University , Manchester , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Nichols","sequence":"additional","affiliation":[{"name":"Advanced Wellbeing Research Centre, Sheffield Hallam University , Sheffield , UK"},{"name":"Sport and Physical Activity Research Centre, Sheffield Hallam University , Sheffield , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Ennis","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust , Clifford Bridge Road, Coventry CV1 3LN , UK"},{"name":"Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick , Coventry , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust , Clifford Bridge Road, Coventry CV1 3LN , UK"},{"name":"Centre for Sport Exercise & Life Sciences, Coventry University , Coventry , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Prosser","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust , Clifford Bridge Road, Coventry CV1 3LN , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Fiassam","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust 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Cardiff , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals Coventry & Warwickshire NHS Trust , Coventry , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3962-5118","authenticated-orcid":false,"given":"Faizel","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals Coventry & Warwickshire NHS Trust , Coventry , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejie","family":"He","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Warwick Medical School, University of Warwick , Coventry , UK"},{"name":"Department of Cardiology, University Hospitals Coventry & Warwickshire NHS Trust , Coventry , 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