{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:25:47Z","timestamp":1793258747795,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Finnish Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of the study was to examine the association between Life\u2019s Essential 8 (LE8) and the risk of cardiovascular and all-cause mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The LE8 was computed for 1662 men, aged 42\u201360 years, without pre-existing history of cardiovascular disease (CVD) at baseline in the Kuopio Ischaemic Heart Disease study. The LE8 factors include diet, physical activity, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and lipids. Each LE8 factor was scored between 0 and 100 points. The summation of all points generated the total LE8 score, which was categorized into quartiles \u2264\u2212420, &amp;gt;420\u2013485, &amp;gt;485\u2013550, and &amp;gt;550. Multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals of LE8 scores for the outcomes. During a median follow-up of 30 years, 402 and 987 men died from CVD and any cause, respectively. The total LE8 score among participants ranged from 185 to 750. The higher the LE8 scores, the lower the risk of dying from CVD and all-cause. Following adjustment for age, alcohol consumption, and socio-economic status, every 50-unit increase in LE8 score was associated with 17% and 14% lower risk of CVD and all-cause deaths, respectively. Men within LE8 top quartile had 60% lower risk of CVD mortality when compared with those within the bottom quartile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Life\u2019s Essential 8 was strongly and inversely associated with the risk of CVD death and all-cause mortality among ageing men. Measures that promote optimal LE8 scores should be encouraged among the general population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad040","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T16:30:51Z","timestamp":1675873851000},"page":"658-667","source":"Crossref","is-referenced-by-count":130,"title":["Life\u2019s Essential 8 and the risk of cardiovascular disease death and all-cause mortality in Finnish men"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-1025","authenticated-orcid":false,"given":"Nzechukwu M","family":"Isiozor","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine, University of Eastern Finland , Yliopistonranta 1, 70211 Kuopio , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setor K","family":"Kunutsor","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, University of Leicester, Leicester General Hospital , Gwendolen Road, Leicester, LE5 4WP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Voutilainen","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1C, Canthia Building , FI-70211 Kuopio , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari A","family":"Laukkanen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Eastern Finland , Yliopistonranta 1, 70211 Kuopio , Finland"},{"name":"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1C, Canthia Building , FI-70211 Kuopio , Finland"},{"name":"Department of Internal Medicine, Central Finland Health Care District, Hoitajantie 3 , 40620 Jyv\u00e4skyl\u00e4 , 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