{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:12:36Z","timestamp":1773411156111,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute aortic dissection (AAD) is the most common acute aortic syndrome. It is a life-threatening condition and surgical emergency associated with high mortality if not treated promptly. While it is well established that cardiovascular disease recognises different pathophysiological pathways between men and women, there is limited evidence of sex differences in AAS, especially in type A AAD. According to a recent synthesis of clinical studies on gender differences in type A AAD, women were found to have different baseline characteristics, presentation and outcomes, and thus sex should be considered relevant for diagnosis, risk-stratification and management of type A AAD.<\/jats:p>","DOI":"10.1093\/eurjpc\/zwad043","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T16:30:53Z","timestamp":1675873853000},"page":"1162-1164","source":"Crossref","is-referenced-by-count":4,"title":["Is female sex impactful in the pathophysiology, presentation, management, and outlook of type A acute aortic dissection?"],"prefix":"10.1093","volume":"30","author":[{"given":"Giacomo","family":"Frati","sequence":"first","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome , Corso della Repubblica 74, 04100 Latina , Italy"},{"name":"IRCCS NEUROMED , Via Atinense 18, 86077 Pozzill , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome , Viale del Policlinico 155, 00161 Roma , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-8510","authenticated-orcid":false,"given":"Giuseppe","family":"Biondi-Zoccai","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome , Corso della Repubblica 74, 04100 Latina , Italy"},{"name":"Mediterranea Cardiocentro , Via Orazio 2, 80122 Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saade","family":"Wael","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome , Viale del Policlinico 155, 00161 Roma , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Giordano","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Interventions, Pineta Grande Hospital , Via Domiziana Km 30, 81030 Castel Volturno , Italy"},{"name":"Operative Unit of Hemodynamics, Santa Lucia Hospital , Via Aielli 109, 80047 S. Giuseppe Vesuviano , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"2023082119001243000_zwad043-B1","first-page":"e223","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"80","author":"Writing Committee Members","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2023082119001243000_zwad043-B2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0003-4975(10)65594-4","article-title":"Management of acute aortic dissections","volume":"10","author":"Daily","year":"1970","journal-title":"Ann Thorac Surg"},{"key":"2023082119001243000_zwad043-B3","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.21037\/jtd-21-119","article-title":"3D morphometric analysis of ascending aorta as an adjunctive tool to predict type A acute aortic dissection","volume":"13","author":"Saade","year":"2021","journal-title":"J Thorac Dis"},{"key":"2023082119001243000_zwad043-B4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.118.004689","article-title":"Population-based assessment of the incidence of aortic dissection, intramural hematoma, and penetrating ulcer, and its associated mortality from 1995 to 2015","volume":"11","author":"DeMartino","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2023082119001243000_zwad043-B5","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.968792","article-title":"Sex\/gender differences in cardiovascular disease prevention: what a difference a decade makes","volume":"124","author":"Mosca","year":"2011","journal-title":"Circulation"},{"key":"2023082119001243000_zwad043-B6","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJM199906103402306","article-title":"The protective effects of estrogen on the cardiovascular system","volume":"340","author":"Mendelsohn","year":"1999","journal-title":"N Engl J Med"},{"key":"2023082119001243000_zwad043-B7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/CIRCRESAHA.116.307547","article-title":"Cardiovascular disease in women: clinical perspectives","volume":"118","author":"Garcia","year":"2016","journal-title":"Circ Res"},{"key":"2023082119001243000_zwad043-B8","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jtcvs.2019.11.039","article-title":". 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