{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:00:36Z","timestamp":1778799636990,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Beijing Outstanding Young Scientist Program","award":["BJJWZYJH01201910023029"],"award-info":[{"award-number":["BJJWZYJH01201910023029"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2021-I2M-1-007"],"award-info":[{"award-number":["2021-I2M-1-007"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["CI2021A00920"],"award-info":[{"award-number":["CI2021A00920"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630014"],"award-info":[{"award-number":["81630014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825002"],"award-info":[{"award-number":["81825002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Intensive systolic blood pressure (SBP) lowering has been increasingly used; however, data is missing on patients who had target-achieved (TA). This study aims to show the cardiovascular effect of maintaining SBP at intensive levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Strategy of Blood Pressure Intervention in Elderly Hypertensive Patients (STEP) trial was a multicentre, randomized, controlled trial which enrolled 8511 young-older (60\u201380 years) hypertensive patients without prior stroke to compare the cardiovascular prognosis of the intensive treatment (SBP target, 110 to &amp;lt;130 mmHg) vs. the standard treatment (130 to &amp;lt;150 mmHg). This secondary analysis assessed data in patients who achieved a mean SBP within target values. The association of mean achieved SBP and cardiovascular events was examined using a cubic spline function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 3053 patients (72.0%) in the intensive-treatment group and 3427 (80.3%) in the standard-treatment group had an SBP target achieved, with mean follow-up SBP values of 124.2 mmHg and 137.4 mmHg, respectively. Throughout the median 3.38-year follow-up, the cardiovascular risk was significantly lower in the TA intensive-treatment group than in the TA standard-treatment group [adjusted hazard ratio (HR) 0.61, 95% confidence interval (CI) 0.46\u20130.80; P &amp;lt; 0.001]. In the intensive-treatment group, patients failing to achieve SBP targets presented higher cardiovascular risk than those TA patients (HR 2.04, 95% CI 1.44\u20132.88; P &amp;lt; 0.001). A J-shaped relationship was observed between the mean achieved SBP and risk of cardiovascular events, with the lowest risk at an SBP of 126.9 mmHg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Maintaining SBP at &amp;lt;130 mmHg offers additional cardiovascular benefits among young-older patients with hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>ClinicalTrials.gov: NCT03015311.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad142","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T18:05:52Z","timestamp":1683914752000},"page":"1017-1027","source":"Crossref","is-referenced-by-count":12,"title":["Achieved systolic blood pressure and cardiovascular outcomes in 60\u201380-year-old patients: the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial"],"prefix":"10.1093","volume":"30","author":[{"given":"Yue","family":"Deng","sequence":"first","affiliation":[{"name":"Hypertension Center, FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences , Beilishi Road 167, Xicheng District, Beijing, 100037 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Bai","sequence":"additional","affiliation":[{"name":"Hypertension Center, FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences , Beilishi Road 167, Xicheng District, Beijing, 100037 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing ChaoYang Hospital, Capital Medical University , Beijing, 100020 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science , Beijing, 100730 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, FuWai Yunnan Cardiovascular Hospital , Kunming, Yunnan, 650106 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Hospital of Shanxi Medical University , Taiyuan, Shanxi, 030001 , 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